You have no items in your shopping cart.
Protein SUMOylation is a key regulatory mechanism in many cell functions, see table of known SUMO-regulated pathways by clicking on the ABOUT tab above.
Cytoskeleton offers highly validated Affinity Beads and antibodies for the study of SUMO-regulated proteins and pathways.
SUMOylation of nuclear actin
J Cell Biol. 2009; 186: 193-200
Cell Division/spindle assembly
SUMOylation modulates the function of Aurora-B kinase
J Cell Sci. 2010; 123: 2823–2833
Cell Cycle–Regulated Attachment of the Ubiquitin-Related Protein Sumo to the Yeast Septins
J Cell Biol. 1999 Nov 29; 147(5): 981–994
SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis
Mol Cell. 2008; 29: 729-741
SUMOylation of the inducible (c-Fos:c-Jun)/AP-1 transcription complex occurs on target promoters to limit transcriptional activation
Oncogene. 2014; 33:921-927
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9
Proc Natl Acad Sci U S A. 2015;112:E1724-33
Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.
J Biol Chem. 20011;286: 2273-2284.
Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy-causing mutations
Mol Biol Cell. 2013; 24: 342-350
Actin filament dynamics
MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibitingMK2 kinase and HSP27 phosphorylation
Blood. 2011; 117(8):2527-2537
SUMOylation of the GTPase Rac1 is required for optimal cellmigration
Nat Cell Biol. 2010;12: 1078-1085
RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility
J Biol Chem. 2012; 287: 13752-13760
X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton
J Biol Chem. 2011; 286: 15630-15640
SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination
Proc Natl Acad Sci U S A. 2014: 16586–16591
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers
Mol Cell Proteomics. 2005; 4: 56-72
Sumoylation of vimentin354 is associated with PIAS3 inhibition of glioma cell migration
Oncotarget. 2010; 1: 620-627
You have no items to compare.
1830 S. Acoma St.
Denver, CO 80223
Tel: 303 322-2254
Fax: 303 322-2257