Dynein: One Motor, Multiple Neurodegenerative Diseases

Cytoplasmic dynein 1 (hereafter referred to as dynein) is a 1.6 MDa multi-protein complex that serves as the primary ATP-hydrolyzing motor responsible for retrograde axonal transport along microtubules (MTs) in eukaryotic cells (Fig. 1A).   Additionally, dynein is essential for many other cellular processes, including mitochondrial movement, endosomal and lysosomal trafficking, transporting mis-folded proteins bound for degradation, nuclear positioning, and mitosis^1-3 (Fig. 2)... Click to read more

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