New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

K-Ras has been identified as the most important Ras protein in cancer research, accounting for over 21% of human cancers. Despite extensive research on these proteins, no effective Ras inhibitor has been identified, earning K-Ras the reputation of an undruggable protein... Here we discuss several leading concepts in the pursuit of identifying viable drug targets to control atypical Ras signaling... Click to read more

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