Acetylation of proteins can occur as a co-translational or post-translational modification (PTM). Co-translational acetylation occurs at the N-terminal of approximately 85% of mammalian proteins, it is irreversible and is thought to be important in protein stability, localization and synthesis. Post-translational acetylation occurs on the epsilon amino group of lysine residues as a reversible and highly dynamic PTM that is known to be a key regulator in multiple cellular events, including chromatin structure, transcription, metabolism, signal transduction and cytoskeletal regulation. Several thousand proteins have been identified by proteomics as targets for PTM acetylation; however, many of these target proteins need validation. Cytoskeleton's Signal-Seeker™ acetylation products offer excellent tools to study acetyl lysine PTM modifications for any target protein.
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