Acetylation of proteins can occur as a co-translational or post-translational modification (PTM). Co-translational acetylation occurs at the N-terminal of approximately 85% of mammalian proteins, it is irreversible and is thought to be important in protein stability, localization and synthesis.
Post-translational acetylation occurs on the epsilon amino group of lysine residues as a reversible and highly dynamic PTM that is known to be a key regulator in multiple cellular events, including chromatin structure, transcription, metabolism, signal transduction and cytoskeletal regulation.
Several thousand proteins have been identified by proteomics as targets for PTM acetylation; however, many of these target proteins need validation. Cytoskeleton's Signal-Seeker™ acetylation products offer excellent tools to study acetyl lysine PTM modifications for any target protein.
Click on the items below for specific product information, or click on the resources tab for validation data, technical tips and other useful links that will enhance your acetylation detection research.