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Williams D. et al. 2024. Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic Modulation. Intl Jrnl of Mol Sci. 2024 25(9), 4647; https://doi.org/10.3390/ijms25094647. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Ying H. et al. 2023. PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms. 2023 Jan;10(2):e2204190. doi: 10.1002/advs.202204190. Epub 2022 Nov 17.. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 – Signal Seeker BK163 Kit & Acetyl-Lysine Affinity Beads AAC04-BEADS Application = IP / Acetyl-Lysine-HRP Antibody Mouse Monoclonal AAC03-HRP Application = WB
He A. et al. 2020. Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Mol Cell. 2020 Jul 2;79(1):30-42.e4. doi: 10.1016/j.molcel.2020.05.007. Epub 2020 May 29. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Losson H. et al. 2020. The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia. Pharmacol Res. 2020 Jun 30;105058. doi: 10.1016/j.phrs.2020.105058. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Aon M. et al. 2020. Untangling Determinants of Enhanced Health and Lifespan Through a Multi-omics Approach in Mice. Cell Metab. 2020 May 11;S1550-4131(20)30235-7. doi: 10.1016/j.cmet.2020.04.018. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Vega M. et al. 2020. Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation. Cells. 2020 Mar 8;9(3):655. doi: 10.3390/cells9030655. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
Elhassan Y. et al. 2019. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. -- Anti-Acetyl-Lysine Monoclonal: (AAC03) -- Application: WB
Sharma M. et al. 2019. Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer. Sci Rep. 2019 Nov 7;9(1):16257. doi: 10.1038/s41598-019-52723-3. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP
Martins V. et al. 2019. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1024-E1035. doi: 10.1152/ajpendo.00497.2018. Epub 2019 Mar 19. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP
Ishihara A. et al. 2019. Seasonal acclimatization and thermal acclimation induce global histone epigenetic changes in liver of bullfrog (Lithobates catesbeianus) tadpole. Comp Biochem Physiol A Mol Integr Physiol. doi: 10.1016/j.cbpa.2018.12.014. -- Anti-Acetyl Lysine Monoclonal: (AAC01-S) --Application:
Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP; Anti-Acetyl Lysine Monoclonal: (AAC02) --Application: IF
Yang Y. et al. 2018. Identification of Acetylated Proteins in Borrelia burgdorferi. Methods Mol Biol. 2018;1690:177-182. doi: 10.1007/978-1-4939-7383-5_14. -- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IP
Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP
LaBarge S.A. et al. 2016. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. Doi: 10.1096/fj.15-281741.-- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IF
ASCB 2017 Poster: Tracking changes in mitochondrial acetylation by immunofluorescence provides new insight into HDACs class I/II and class III crosstalk -- Anti-Acetyl-Lysine Monoclonal: (AAC02), Signal-Seeker™ kit BK163 (Ac)
ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)
ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)
Acetyl Lysine White Paper: Utilization of newly developed mouse monoclonal anti-acetyl lysine antibodies in western blot and immunoprecipitation applications
Anti-Acetyl Lysine Mitochondrial Protein Immunofluorescence White Paper
Nguyen MTH. et. al. Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition. Front Cardiovasc Med. 2023 Aug 30:10:1187490. doi: 10.3389/fcvm.2023.1187490. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Yan CH. et. al. AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120. Nat Commun. 2022 Dec 13;13(1):7721. doi: 10.1038/s41467-022-34996-x. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Garvin A. et. al. SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect types of SUMO conjugate. Sci Rep. 2022 Dec 9;12(1):21343. doi: 10.1038/s41598-022-25665-6. – anti SUMOylation 2/3 monoclonal: (ASM23) – Application: WB
Andreev V. et al. 2022. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Nat Struct Mol Biol. 2022 Feb;29(2):130-142. doi: 10.1038/s41594-022-00721-x. Epub 2022 Feb 16. – anti SUMOylation 2/3 monoclonal: (ASM23) – Application: WB
Juncker M. et al. 2021. ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cells. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(6):166102. doi: 10.1016/j.bbadis.2021.166102. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Kim C. et al. 2021. SUMOylation of mitofusins: a potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressors. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1; 1867(6): 166104.-- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Zhang H. et al. 2020. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020 Jun 24;mbcE19100589. doi: 10.1091/mbc.E19-10-0589. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: IF
Zhou L. et al. 2020. SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Signal Transduct Target Ther. 2020 Jun 24;5(1):80. doi: 10.1038/s41392-020-0172-4. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: WB
Yan Y. et al. 2019. DPPA2/4 and SUMO E3 Ligase PIAS4 Opposingly Regulate Zygotic Transcriptional Program. PLoS Biol. 2019 Jun 21;17(6):e3000324. doi: 10.1371/journal.pbio.3000324. eCollection 2019 Jun. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: PLA
Dubuisson L. et al. 2018. Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner. Oncogene. doi: 10.1038/s41388-018-0163-x. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Kaci A. et al. 2018. The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α. Sci Rep. doi: 10.1038/s41598-018-29448-w. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP
SUMOylation 2/3 White Paper: Validation of SUMO-2/3 Antibodies (12F3 and 11G2) in Western Blot, Immunoprecipitation and Immunofluorescence Applications
SUMO 2/3 White Paper: Tips for utilizing SUMO 2/3 Detection Reagents and Kits to identify endogenous SUMOylation 2/3 modified target proteins in cells and tissue
Ahler E. et al. 2019. A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Mol Cell. 2019 Apr 18;74(2):393-408.e20. doi: 10.1016/j.molcel.2019.02.003. Epub 2019 Apr 4. -- Anti-Phosphotyrosine Monoclonal: (APY03) -- Application: WB
Landeck N. et al. 2019. Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein. Biorxiv. https://doi.org/10.1101/700377. -- Anti-Phosphotyrosine Monoclonal: (APY03-HRP) -- Application: WB
Seki T. et al. 2018. Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning. J Exp Med. doi: 10.1084/jem.20171012. -- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IP
Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK160 (pY) --Application: IP
Kline A. et al. 2018. The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber. Dev Biol. pii: S0012-1606(18)30067-8. doi: 10.1016/j.ydbio.2018.05.006. -- Anti-Phosphotyrosine Monoclonal: (APY03)
Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK160 (pY) --Application: IP
Yusuf M.Z. et al. 2017. Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability. Sci Rep. Doi: 10.1038/s41598-017-05817-9.-- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IF
Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK160 (pY) --Application: IP
Kaukonen R. et al. 2016. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. Doi: 10.1038/ncomms12237.-- Anti-Phosphotyrosine Monoclonal: (APY03), Phosphotyrosine Affinity Beads (APY03-Beads) --Application: WB, IP
ASCB 2015 Poster: Temporal regulation of phosphotyrosine-modified Rac1 in response to epidermal growth factor stimulation -- Signal-Seeker™ kit: BK160 (pY)
Phosphotyrosine White Paper: Comparison of Phosphotyrosine Antibodies 27B10.4 and 4G10 in Immunoprecipitation, Immunofluorescence and Western Blot Applications
Guo Q. et. al. TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation. Cell Rep. 2023 Sep 26;42(9):113070. doi: 10.1016/j.celrep.2023.113070.. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Huang X. et. al. Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2B. Open Med. 2023 Jun 16;18(1):20230718. doi: 10.1515/med-2023-0718. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Tahaei E. et. al. Pendrin regulation is prioritized by anion in high-potassium diets. Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F256-F266. doi: 10.1152/ajprenal.00128.2022. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Wang Y. et. al. MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discov. 2023 Feb 21;9(1):20. doi: 10.1038/s41421-022-00507-x. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Kholmanskikh S. et. al. Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1. Sci Rep. 2022 Oct 3;12(1):16493. doi: 10.1038/s41598-022-19740-1. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Martin, T.G., Myers, V.D., Dubey, P. et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun 12, 2942 (2021). https://doi.org/10.1038/s41467-021-23272-z - -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF
Sebastian M. Dieter, et al., Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer, Cell Reports, Volume 36, Issue 3, 2021, 109394, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2021.109394.
Uchiyama M. et al. 2020. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. Current Biology. 2020 Sep 7;30(17):3378-3396.e7. doi: 10.1016/j.cub.2020.06.047. Epub 2020 Jul 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Sen A. et al. 2020. The Na + pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization. J Cell Sci. 2020 Aug 21;133(16):jcs245415. doi: 10.1242/jcs.245415. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Park J. et al. 2020. Mechanical Regulation of Glycolysis via Cytoskeleton Architecture. Nature. 2020 Feb;578(7796):621-626. doi: 10.1038/s41586-020-1998-1. Epub 2020 Feb 12. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Tumova L. et al. 2020. The Ubiquitin-Proteasome System Does Not Regulate the Degradation of Porcine β-Microseminoprotein during Sperm Capacitation. Int J Mol Sci. 2020 Jun 10;21(11):4151. doi: 10.3390/ijms21114151. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Frindt G. et al. 2020. Ubiquitination of Renal ENaC Subunits in Vivo. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1113-F1121. doi: 10.1152/ajprenal.00609.2019. Epub 2020 Mar 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Gu C. et al. 2020. Identification of Berberine as a Novel Drug for the Treatment of Multiple Myeloma via Targeting UHRF1. BMC Biol. 2020 Mar 25;18(1):33. doi: 10.1186/s12915-020-00766-8. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Manzione M. et al. 2020. Co-regulation of the Antagonistic RepoMan:Aurora-B Pair in Proliferating Cells. Mol Biol Cell. 2020 Mar 15;31(6):419-438. doi: 10.1091/mbc.E19-12-0698. Epub 2020 Jan 22. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB
Rivas J. et al. 2020. KCTD5, a Novel TRPM4-regulatory Protein Required for Cell Migration as a New Predictor for Breast Cancer Prognosis. Am J Physiol Renal Physiol. FASEB J. 2020 Apr 17. doi: 10.1096/fj.201901195RRR. Online ahead of print. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB
Wenzel HJ. et al. 2019. Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathol Commun. doi: 10.1186/s40478-019-0677-7. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF
Brophy M. et al. 2019. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res. doi: 10.1161/CIRCRESAHA.118.313028. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB
Martini V. et al. 2018. Abnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia. Oncotarget. doi: 10.18632/oncotarget.25951. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP
Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP
Alvarez A. et al. 2017. KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Front Cell Infect Microbiol. 2017 Oct 24;7:450. doi: 10.3389/fcimb.2017.00450. -- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB
Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP
Braganza A. et al. 2017. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. Doi: 10.1074/jbc.M116.766824.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB
Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK161--Application: IP
Rahman H.N.A. et al. Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Cir Res. Doi: 10.1161/CIRCRESAHA.115.307679.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB
Hukema R.K. et al. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. Doi: 10.1093/hmg/ddv216.-- Anti-Ubiquitin Monoclonal: (AUB01-S) --Application: IF
Ubiquitination White Paper -- Signal-Seeker™ kits: BK161 (Ub), Ubiquitination affinity beads (UBA01-beads), Ubiquitination control beads (CUB02), HRP-Anti-Ubiquitin Monoclonal: AUB01-HRP
Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 BlastR Rapid Lysate Prep Kit BLR01, BlastR Rapid Filtration Kit BLR02, BlastR™ Lysis/Dilution Buffer Kit BLR03
Tanimoto, A. et al. Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression doi: 10.1158/1078-0432.CCR-20-2853 BlastR Rapid Lysate Prep Kit BLR01
Horita H. et al. 2018. Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins. J. Vis. Exp. (131), e56912, doi:10.3791/56912. -- Signal-Seeker™ kits
ASCB 2016 Poster: Complete removal of genomic DNA from cell lysate enhances the quality of protein research -- BlastR™ Filter (BLR02)
BlastR™ Buffer Comparison with conventional lysis buffers -- BlastR™ Rapid Lysate Prep kit (BLR01, BLR02)
Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kits
Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3), BK163 (Ac)
cJUN White Paper -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)