Small G-Protein: Validation Data

Small G-Protein: Selected Validated Data

Below are selected Citations for each Small G-Protein, scroll below to see citations for your protein of interest. If you're interested in a more complete list - each product page has a complete citation listing for that product.

Arf Validation Data:

Rafiq, N. B. M. et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J. Cell Biol. 216, 181–197 (2017).

Yu, Q. et al. A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostate. J. Biol. Chem. 294, 12231–12248 (2019).

Abdul-Salam, V. B. et al. CLIC4/Arf6 Pathway: A New Lead in BMPRII Inhibition in Pulmonary Hypertension. Circ. Res. 124, 52–65 (2019).

Rafiq, N. B. M. et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J. Cell Biol. 216, 181–197 (2017).

Andrews, A. M., Lutton, E. M., Merkel, S. F., Razmpour, R. & Ramirez, S. H. Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury. Front. Cell. Neurosci. 10, 43 (2016).

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Cdc42 Validation Data:

Eggers et al., 2012. STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells. J. Biol. Chem. 287, 18758-18768.

Zhang, X. et al. Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration. JCI Insight 5, (2020).

Krueger, I. et al. Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPases. Arterioscler. Thromb. Vasc. Biol. 40, 2391–2403 (2020).

Liu et al., 2004. Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Cζ (PKCζ) and regulates PKCζ activity. Mol. Cell. Biol. v 24, pp 6665-6675.

Sasai et al., 2004. The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. Nat. Cell Biol. v 6, pp 741-748.

Rac1 Validation Data:

Kikuchi et al., 2012. Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. Oncogene. doi:10.1038/onc.2012.46.

Moniz et al. (2008). WNK2 modulates MEK1 activity through the Rho GTPase pathway. Cellular Signalling 20 ,1762-68.

Choraghe, R. P., Kołodziej, T., Buser, A., Rajfur, Z. & Neumann, A. K. RHOA-mediated mechanical force generation through Dectin-1. J. Cell Sci. 133, jcs236166 (2020).

Shin, S. K. et al. Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling. J. Gastroenterol. Hepatol. 35, 1078–1087 (2020).

Thamilselvan, T. et al. P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells. Cell. Physiol. Biochem. 54, 1218–1230 (2020).

Ras Validation Data:

Kim, J. H. et al. Rational design of small molecule RHOA inhibitors for gastric cancer. Pharmacogenomics J. 20, 601–612 (2020).

Li, Q. fen, Decker-Rockefeller, B., Bajaj, A. & Pumiglia, K. Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic Stroke. Cell Rep. 24, 2869–2882 (2018).

S.-J. Lee et al. 2013. Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and krüppel-like factor 5. J. Biol. Chem. 288, 25244-25253.

Gil-Henn et al. 2012. Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Oncogene. doi:10.1038/onc.2012.284.

Lito et al., 2008. Evidence that sprouty 2 is necessary for sarcoma formationby H-Ras oncogene-transformed human fibroblasts. J. Biol. Chem. v 283, pp 2002-2009.

Ral Validation Data:

Hiatt, S. M. et al. De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay. PLOS Genet. 14, e1007671 (2018).

Gu, C. et al. RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia. Oncotarget 7, 20561–20573 (2016).

Papini D. et al. 2015. TD-60 links RalA GTPase function to the CPC in mitosis. Nat. Commun. 6, 7678.

Ribback et al., 2013. Molecular and metabolic changes in human liver clear cell foci resemble the alterations occurring in rat hepatocarcinogenesis. J. Hepatology. http://dx.doi.org/10.1016/j.jhep.2013.01.013.

RhoA Validation Data:

Algaber, A. et al. MicroRNA-340-5p inhibits colon cancer cell migration via targeting of RhoA. Sci. Rep. 10, 16934 (2020).

Choraghe, R. P., Kołodziej, T., Buser, A., Rajfur, Z. & Neumann, A. K. RHOA-mediated mechanical force generation through Dectin-1. J. Cell Sci. 133, jcs236166 (2020).

Jin et al. (2011). Increased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice. J Clin Invest.

Mercer and Helenius (2008). Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells. Science 320 ,531.

Wee, K. et al. Snail induces epithelial cell extrusion by regulating RhoA contractile signalling and cell–matrix adhesion. J. Cell Sci. 133, (2020).

Kitchen, G. B. et al. The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia. Proc. Natl. Acad. Sci. U. S. A. 117, 1543–1551 (2020).

RhoGAP-GEF Validation Data:

Raf Validation Data:

Malilas et al., 2013. Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling. Cancer Gene Ther. doi:10.1038/cgt.2012.96.

Takeishi et al., 2012. Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras–Raf–MEK–ERK pathway. J. Hepatol. 57, 77-83.

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