Cytoskeleton Inc Activation Assay Validation Data and Citations

Activation Assay Citations

AuthorTitleJournalYearArticle Link
Gao, Fei et al.STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cellsOncoTargets and Therapy2018
Rafiq, Nisha Bte Mohd et al.Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNOThe Journal of cell biology2017
Rennoll-Bankert, Kristen E. et al.RalF-Mediated Activation of Arf6 ControlsRickettsia typhiInvasionby Co-Opting Phosphoinositol MetabolismInfect Immun2016
Schultz, Mark L. et al.CLN3 Deficient Cells Display Defects in the ARF1-Cdc42 Pathway and Actin-Dependent EventsPLOS ONE2014
AuthorTitleJournalYearArticle Link
Borghesan, Elizabeth et al. A Brucella effector modulates the Arf6‐Rab8a GTPase cascade to promote intravacuolar replication The EMBO Journal2021
Jackson, Matilda R. et al.Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in femalesLife Science Alliance2019
Rafiq, Nisha Bte Mohd et al.Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNOThe Journal of cell biology2017
Stepicheva, Nadezda A. et al.The small GTPase Arf6 regulates sea urchin morphogenesisDifferentiation; research in biological diversity2017
Biesemann, Anja et al.Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodiesThe Journal of biological chemistry2017
Rennoll-Bankert, Kristen E. et al.RalF-Mediated Activation of Arf6 ControlsRickettsia typhiInvasionby Co-Opting Phosphoinositol MetabolismInfect Immun2016
Andrews, Allison M. et al.Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain InjuryFrontiers in Cellular Neuroscience2016
Marchesin, Valentina et al.ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-Actin rosettes in breast cancer cells in response to epidermal growth factorPLoS ONE2015
AuthorTitleJournalYearArticle Link
Ji, Juanjuan et al.TMEM16A enhances the activity of the Cdc42-NWASP signaling pathway to promote invasion and metastasis in oral squamous cell carcinomaOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology2024
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Liang, Bishan et al.Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancerCancer Letters2024
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Szigeti, Kinga et al.Neuronal actin cytoskeleton gain of function in the human braineBioMedicine2023
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Punessen, Noelle C. et al.A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neuronsMolecular and Cellular Neuroscience2023
St. Paul, Amanda et al.FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanismsCell reports2023
Castillo-Azofeifa, David et al.A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signalingCell stem cell2023
Crespo, Grace Velez et al.The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancerMolecular Medicine2023
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Zi, Jingjing et al.PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNKCells2022
Meng, Zhipeng et al.The Hippo pathway mediates Semaphorin signalingScience Advances2022
Jiang, Ruiwei et al.CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transportCell Death & Disease2022
Ma, Yuanyuan et al.Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root developmentDevelopment (Cambridge)2021
Jozic, Ivan et al.Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing woundsCommunications Biology2021
Vallejo, Daniela et al.Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neuronsJournal of Neurochemistry2021
Wurzer, Hannah et al.Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton RemodelingFrontiers in Immunology2021
Merlin, Johanna et al.Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylationNature Metabolism2021
Lee, DanielmiR‑769‑5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cellsExperimental and Therapeutic Medicine2021
Salameh, Joëlle et al.Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubulesCurrent Biology2021
Talamás-Lara, Daniel et al.Entamoeba histolytica and Entamoeba dispar: Morphological and Behavioral Differences Induced by Fibronectin through GTPases Activation and Actin-Binding ProteinsThe Journal of eukaryotic microbiology2020
Krueger, Irena et al.Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPasesArteriosclerosis, Thrombosis, and Vascular Biology2020
Rong, Zhouyi et al.Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine modelsFASEB Journal2020
Andrews, Madeline G. et al.Mtor signaling regulates the morphology and migration of outer radial glia in developing human cortexeLife2020
Choraghe, Rohan P. et al.RHOA-mediated mechanical force generation through Dectin-1Journal of cell science2020
Malek, Natalia et al.Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) technique shows that non-muscle β and γ actin are not equal in relation to human melanoma cells’ motility and focal adhesion formationInternational Journal of Molecular Sciences2020
Wilson, Kitchener D. et al.Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human PrimatesDevelopmental Cell2020
Reyes-Miguel, Tania et al.CDC42 drives RHOA activity and actin polymerization during capacitationReproduction2020
Ursino, Gloria M et al.ABCA12 regulates insulin secretion from β‐cellsEMBO reports2020
Novak, Caymen M. et al.Compressive stimulation enhances ovarian cancer proliferation, invasion, chemoresistance, and mechanotransduction via cdc42 in a 3d bioreactorCancers2020
Wu, Huijuan et al.Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem CellsCell2020
Zhang, Xiao et al.Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regenerationJCI Insight2020
Gorisse, Laetitia et al.Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42Journal of Biological Chemistry2020
Zanin, Juan P. et al.The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitorsJournal of Neuroscience2019
Wu, Xuping et al.Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cellsCancer Management and Research2019
Santhana Kumar, Karthiga et al.TGF-β Determines the Pro-migratory Potential of bFGF Signaling in MedulloblastomaCell Reports2018
Yan, Ting et al.Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cellsJournal of Biological Chemistry2018
Suraneni, Praveen K. et al.Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activityBlood Advances2018
Mayer, Louisa et al.Nbeal2 interacts with Dock7, Sec16a, and Vac14Blood2018
Veluthakal, Rajakrishnan et al.Restoration of glucose-stimulated Cdc42-PAK1 activation and insulin secretion by a selective Epac activator in type 2 diabetic human isletsDiabetes2018
Gu, Changkyu et al.Dynamin autonomously regulates podocyte focal adhesion maturationJournal of the American Society of Nephrology2017
Ruggiero, Carmen et al.Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasionScience Signaling2017
Kim, Jongshin et al.YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturationJournal of Clinical Investigation2017
Xiao, Bin et al.Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signalingOncotarget2016
Jones, Eleanor L. et al.Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37The Journal of Immunology2016
Sroka, Jolanta et al.Lamellipodia and membrane blebs drive efficient electrotactic migration of rat walker carcinosarcoma cells WC 256PLoS ONE2016
Zhao, Chen Ze et al.Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodelingScientific Reports2016
Tien, Sui Chih et al.The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42Nature Communications2016
Martins, Rui et al.Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functionsNature Immunology2016
Herrera-Martínez, Mayra et al.Antiamoebic activity of Adenophyllum aurantium (L.) strother and its effect on the actin cytoskeleton of Entamoeba histolyticaFrontiers in Pharmacology2016
Ochoa-Alvarez, Jhon A. et al.Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanismsOncotarget2015
Guo, Yuna et al.A novel pharmacologic activity of keto***** for therapeutic benefit in ovarian cancer patientsClinical Cancer Research2015
Breslin, Jerome W. et al.Involvement of local lamellipodia in endothelial barrier functionPLoS ONE2015
Yan, Yi et al.Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5Nature Communications2015
Hanin, Geula et al.Competing targets of microRNA-608 affect anxiety and hypertensionHuman Molecular Genetics2014
Ahn, Bum Ju et al.Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamicsJournal of Biological Chemistry2014
Rigano, Luciano A. et al.Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spreadCellular Microbiology2014
Chakravarti, Bandana et al.Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agentsJournal of Medicinal Chemistry2014
Kalia, Manjula et al.Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic MechanismJournal of Virology2013
Yao, Honghong et al.Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrinsFASEB journal2013
Dubash, Adi D. et al.The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1Journal of Cell Biology2013
Ramsay, Alan G. et al.Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenali******Blood2013
Bray, Kristi et al.Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migrationBreast Cancer Research2013
Chen, Bin et al.Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fractionCellular Physiology and Biochemistry2013
Yang, Jian et al.Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in miceCardiovascular Research2013
Valtcheva, Nadejda et al.The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42Journal of Biological Chemistry2013
Barrio, Laura et al.TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPasesThe Journal of Immunology2013
Chen, Guang et al.Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2Journal of Biological Chemistry2012
Dhaliwal, Anandika et al.Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPasesPLoS ONE2012
Eggers, Carrie M. et al.STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cellsThe Journal of biological chemistry2012
Ramsay, Alan G. et al.Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancerBlood2012
Chen, Si Meng et al.Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTORBiochemical Pharmacology2012
Elali, Ayman et al.Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cellsBrain Pathology2012
Martin-Granados, Cristina et al.A role for PP1/NIPP1 in steering migration of human cancer cellsPLoS ONE2012
Lichtenstein, Mathieu P. et al.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivativesJournal of Alzheimer's disease : JAD2010
McHenry, Peter R. et al.P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasisBreast Cancer Research2010
Romero, Ana M. et al.Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary cultureToxicological Sciences2010
Stankiewicz, Traci E. et al.GTPase activating protein function of p85 facilitates uptake and recycling of the β1 integrinBiochemical and biophysical research communications2010
Heckman-Stoddard, Brandy M. et al.Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression2009
Schlegel, Nicolas et al.Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endotheliumMicrocirculation (New York, N.Y. : 1994)2009
AuthorTitleJournalYearArticle Link
He, Yi et al.CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasisCell reports2023
Phuyal, Santosh et al.Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1The EMBO Journal2022
Nath, Anu S. et al.Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responsesCell Reports2022
Turgu, Busra et al.HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent mannerOncogene2021
Garitano-Trojaola, Andoni et al.Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemiaCommunications biology2021
Zhu, Bili et al.Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: An early event prior to insulin resistanceTheranostics2020
Berthenet, Kevin et al.Failed Apoptosis Enhances Melanoma Cancer Cell AggressivenessCell Reports2020
Crawford, Melissa et al.Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the SkinJournal of Investigative Dermatology2020
Elshaer, Sally L. et al.Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathwayDiabetologia2019
El-Naggar, Amal M. et al.HACE1 is a potential tumor suppressor in osteosarcomaCell Death and Disease2019
Yan, Ting et al.Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cellsJournal of Biological Chemistry2018
Kang, Jeong Hun et al.Protein kinase Cα as a therapeutic target in cancerProtein Kinase C: Emerging Roles and Therapeutic Potential2018
Kai, Masahiro et al.Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancerMolecular Carcinogenesis2017
Jeong, Suk Yeong et al.Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signalingOncotarget2017
Ruggiero, Carmen et al.Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasionScience Signaling2017
Kim, Jongshin et al.YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturationJournal of Clinical Investigation2017
Thuault, Sylvie et al.The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activityMolecular Biology of the Cell2016
Sylow, Lykke et al.Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in miceJournal of Physiology2016
Sarowar, Tasnuva et al.Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2Molecular Brain2016
Marchesin, Valentina et al.ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-Actin rosettes in breast cancer cells in response to epidermal growth factorPLoS ONE2015
Reyes-Reyes, E. Merit et al.Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activationMolecular Oncology2015
Yan, Yi et al.Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5Nature Communications2015
Sylow, Lykke et al.Rac1 - a novel regulator of contraction-stimulated glucose uptake in skeletal muscleExperimental Physiology2014
Radeva, Mariya Y. et al.PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulationPLoS ONE2014
Nakajima, Chikako et al.The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular developmentDevelopment (Cambridge)2014
Kikuchi, K. et al.Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcomaOncogene2013
Bray, Kristi et al.Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migrationBreast Cancer Research2013
Sylow, Lykke et al.Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscleDiabetes2013
Redhu, Naresh Singh et al.Thymic stromal lymphopoietin induces migration in human airway smooth muscle cellsScientific Reports2013
Eggers, Carrie M. et al.STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cellsThe Journal of biological chemistry2012
Sayedyahossein, Samar et al.Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytesFASEB Journal2012
Vives, Virginie et al.The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts2011
Binker, Marcelo G. et al.TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2Biochemical and biophysical research communications2011
Kigel, Boaz et al.Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signalingBlood2011
McHenry, Peter R. et al.P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasisBreast Cancer Research2010
Johanna, Gutiérrez Vargas et al.Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemiaNeurochemistry international2010
Kamai, Takao et al.Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancerBMC Cancer2010
Baumer, Y. et al.Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdownJournal of Cellular Physiology2009
Heckman-Stoddard, Brandy M. et al.Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Moniz, Sónia et al.WNK2 modulates MEK1 activity through the Rho GTPase pathwayCellular signalling2008
Ramirez, Servio H. et al.Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected MonocytesThe Journal of Immunology2008
Petroll, W. Matthew et al.Dynamic assessment of fibroblast mechanical activity during rac-induced cell spreading in 3-D cultureJournal of Cellular Physiology2008
Pontow, Suzanne et al.Antiviral Activity of a Rac GEF inhibitor Characterized with a Sensitive HIV/SIV Fusion AssayVirology2007
AuthorTitleJournalYearArticle Link
Morstein, Johannes et al.Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.Cell2024
Tanaka, Masato et al.Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseasesCommunications Biology 2024
Wu, Yi et al.Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtiaJournal of Cellular and Molecular Medicine2024
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Raykhel, I. et al.HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxiaScientific Reports 2024
Liu, Xiaomin et al.RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulationJournal of Virology2024
Koenis, Duco Steven et al.Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of GlycolysisAdvanced Science2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Vahldieck, Carl et al.Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axisFrontiers in Immunology2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Laragione, Teresina et al.KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypesFrontiers in Immunology2024
Moztarzadeh, Sina et al.Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activationScientific Reports2024
Hong, Geunhye et al.Campylobacter jejuni Modulates Reactive Oxygen Species Production and NADPH Oxidase 1 Expression in Human Intestinal Epithelial CellsCellular Microbiology2023
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Szigeti, Kinga et al.Neuronal actin cytoskeleton gain of function in the human braineBioMedicine2023
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Takaya, Kento et al.Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPKBiomedicines2023
Wang, Yanan et al.PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell ComplexNature Communications 2023
Toffali, Lara et al.An isoform of the giant protein titin is a master regulator of human T lymphocyte traffickingCell reports2023
Turgu, Busra et al. The HACE1 E3 ligase mediates RAC1 ‐dependent control of mTOR signaling complexes EMBO reports2023
Bartos, Katalin et al.Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activityJournal of Cell Communication and Signaling2023
St. Paul, Amanda et al.FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanismsCell reports2023
Castillo-Azofeifa, David et al.A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signalingCell stem cell2023
Dang, Iren et al.Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Journal of Cell Science2023
Tokarz, Victoria L. et al.Palmitate-induced insulin resistance causes actin filament stiffness and GLUT4 mis-sorting without altered Akt signallingJournal of Cell Science2023
Carbonell, Abigail U. et al.Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signalingFrontiers in Aging Neuroscience2023
Crespo, Grace Velez et al.The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancerMolecular Medicine2023
Darp, Revati et al.Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesisNature Communications2022
Harms, Julia et al.Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasionCancer Gene Therapy 2022
Francis, Caitlin R. et al.Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesisNature Communications 2022
Kim, Seunghoon et al.Investigating the Anti-Inflammatory Effects of RCI001 for Treating Ocular Surface Diseases: Insight Into the Mechanism of ActionFrontiers in Immunology2022
Sugisawa, Erika et al.Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microgliaCell Reports2022
Ma, Yuanyuan et al.Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root developmentDevelopment (Cambridge)2021
Gurusamy, Malarvizhi et al.G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediatorsNature Communications2021
Kinsella, Sinéad et al.Attenuation of apoptotic cell detection triggers thymic regeneration after damageCell Reports2021
Mao, De Yu et al.CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and functionScience Signaling2021
Wegscheid, Michelle L. et al.Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesisCell Reports2021
Vallejo, Daniela et al.Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neuronsJournal of Neurochemistry2021
Krueger, Irena et al.Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPasesArteriosclerosis, Thrombosis, and Vascular Biology2020
Rong, Zhouyi et al.Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine modelsFASEB Journal2020
Kowluru, Renu A.Retinopathy in a diet-induced type 2 diabetic rat model and role of epigenetic modificationsDiabetes2020
Andrews, Madeline G. et al.Mtor signaling regulates the morphology and migration of outer radial glia in developing human cortexeLife2020
Sheftel, Celeste M. et al.Serotonin stimulated parathyroid hormone related protein induction in the mammary epithelia by transglutaminase-dependent serotonylationPLoS ONE2020
Choraghe, Rohan P. et al.RHOA-mediated mechanical force generation through Dectin-1Journal of cell science2020
Malek, Natalia et al.Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) technique shows that non-muscle β and γ actin are not equal in relation to human melanoma cells’ motility and focal adhesion formationInternational Journal of Molecular Sciences2020
Szrejder, Maria et al.Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditionsBiochimica et Biophysica Acta - Molecular Basis of Disease2020
Wilson, Kitchener D. et al.Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human PrimatesDevelopmental Cell2020
Angé, Marine et al.α1AMP-Activated Protein Kinase Protects against Lipopolysaccharide-Induced Endothelial Barrier Disruption via Junctional Reinforcement and Activation of the p38 MAPK/HSP27 PathwayInternational Journal of Molecular Sciences2020
Gokoffski, Kimberly K. et al.Physiologic electrical fields direct retinal ganglion cell axon growth in vitroInvestigative Ophthalmology and Visual Science2019
Wang, Baomei et al.Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced ColitisCell Reports2019
Haq, Naila et al.Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neuronsPLoS Biology2019
Zanin, Juan P. et al.The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitorsJournal of Neuroscience2019
Stefanelli, Victoria L. et al.Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasionMatrix Biology2019
Laufer, Julia M. et al.Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac ActivationCell Reports2019
Santhana Kumar, Karthiga et al.TGF-β Determines the Pro-migratory Potential of bFGF Signaling in MedulloblastomaCell Reports2018
Caggia, Silvia et al.Novel role of Giα2 in cell migration: Downstream of PI3-kinase–AKT and Rac1 in prostate cancer cellsJournal of Cellular Physiology2018
Suraneni, Praveen K. et al.Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activityBlood Advances2018
Saito-Reis, Chelsea A. et al.The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cellsMolecular Biology of the Cell2018
Rachubik, Patrycja et al.The TRPC6-AMPK pathway is involved in insulin-dependent cytoskeleton reorganization and glucose uptake in cultured rat podocytesCellular Physiology and Biochemistry2018
Dyberg, Cecilia et al.Rho-associated kinase is a therapeutic target in neuroblastomaProceedings of the National Academy of Sciences of the United States of America2017
Chen, Guo Ping et al.Inhibition of farnesyl pyrophosphate synthase attenuates high glucose-induced vascular smooth muscle cells proliferationMolecular Medicine Reports2017
Gu, Changkyu et al.Dynamin autonomously regulates podocyte focal adhesion maturationJournal of the American Society of Nephrology2017
Ubba, Vaibhave et al.RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat ModelReproductive Sciences2017
Kumar, Vijay et al.Integrin beta8 (ITGB8) activates VAV-RAC1 signaling via FAK in the acquisition of endometrial epithelial cell receptivity for blastocyst implantationScientific Reports2017
Rom, Slava et al.PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrierJournal of Neuroinflammation2016
Hamers, Anouk A.J. et al.Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and toleranceBMC Genomics2016
Xiao, Bin et al.Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signalingOncotarget2016
Jones, Eleanor L. et al.Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37The Journal of Immunology2016
Sroka, Jolanta et al.Lamellipodia and membrane blebs drive efficient electrotactic migration of rat walker carcinosarcoma cells WC 256PLoS ONE2016
Zhao, Chen Ze et al.Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodelingScientific Reports2016
Sayyad, Wasim A. et al.The role of Rac1 in the growth cone dynamics and force generation of DRG neuronsPLoS ONE2016
Rom, Slava et al.The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 ltr inhibition and diminution in Rho GTPase activityFrontiers in Microbiology2015
Rom, Slava et al.Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditionsJournal of Cerebral Blood Flow and Metabolism2015
Ochoa-Alvarez, Jhon A. et al.Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanismsOncotarget2015
Guo, Yuna et al.A novel pharmacologic activity of keto***** for therapeutic benefit in ovarian cancer patientsClinical Cancer Research2015
Breslin, Jerome W. et al.Involvement of local lamellipodia in endothelial barrier functionPLoS ONE2015
Herberich, Stefanie E. et al.ANKS1B Interacts with the cerebral cavernous malformation protein-1 and controls endothelial permeability but not sprouting angiogenesisPLoS ONE2015
Mackay, Joanna L. et al.Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promotersIntegrative Biology (United Kingdom)2014
Marinković, Goran et al.6-mercaptopurine reduces macrophage activation and gut epithelium proliferation through inhibition of GTPase Rac1Inflammatory Bowel Diseases2014
Marinković, Goran et al.Inhibition of GTPase Rac1 in Endothelium by 6-Mercaptopurine Results in Immunosuppression in Nonimmune Cells: New Target for an Old DrugThe Journal of Immunology2014
Papke, Christina L. et al.Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-βHuman Molecular Genetics2013
Kalia, Manjula et al.Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic MechanismJournal of Virology2013
Rom, Slava et al.Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrierAmerican Journal of Pathology2013
Dubash, Adi D. et al.The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1Journal of Cell Biology2013
Ramsay, Alan G. et al.Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenali******Blood2013
Chen, Bin et al.Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fractionCellular Physiology and Biochemistry2013
Yang, Jian et al.Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in miceCardiovascular Research2013
Chen, Guang et al.Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2Journal of Biological Chemistry2012
Greco, Carolina M. et al.Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptorCardiovascular Research2012
Ramsay, Alan G. et al.Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancerBlood2012
Chen, Si Meng et al.Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTORBiochemical Pharmacology2012
Antonov, Alexander S. et al.Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90Journal of cellular physiology2012
Oshikawa, Jin et al.Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cellsAmerican Journal of Physiology - Heart and Circulatory Physiology2012
Montalvo-Ortiz, Brenda L. et al.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseThe Journal of biological chemistry2012
Stefanini, Lucia et al.Rap1-Rac1 circuits potentiate platelet activationArteriosclerosis, thrombosis, and vascular biology2012
Arpaia, E. et al.The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and ErkOncogene2012
Rom, Slava et al.Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformationAmerican Journal of Pathology2012
Sánchez, Elena G. et al.African swine fever virus uses macropinocytosis to enter host cellsPLoS Pathogens2012
Vives, Virginie et al.The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts2011
AuthorTitleJournalYearArticle Link
Bhosle, Vikrant K. et al.SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killingLife Science Alliance2023
Mishra, Abhinava K. et al.Hyperactive Rac stimulates cannibalism of living target cells and enhances CAR-M- mediated cancer cell killingProceedings of the National Academy of Sciences2023
Bhosle, Vikrant K. et al.The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureuseLife2023
Barbakadze, Tamar et al.3,5,3'-Triiodo-L-Thyronine Regulates Actin Cytoskeleton Dynamic in The Differentiated PC-12 Cells during Hypoxia through An αvβ3 IntegrinCell Journal (Yakhteh)2023
Talwar, Shefali et al.Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and RhoCell Reports2021
Lagresle-Peyrou, Chantal et al.A gain-of-function RAC2 mutation is associated with bone marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiencyHaematologica2021
Talamás-Lara, Daniel et al.Entamoeba histolytica and Entamoeba dispar: Morphological and Behavioral Differences Induced by Fibronectin through GTPases Activation and Actin-Binding ProteinsThe Journal of eukaryotic microbiology2020
Cash, Jennifer N. et al.Discovery of small molecules that target the phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) PIP3-binding site and inhibit p-Rex1-dependent functions in neutrophilsMolecular Pharmacology2020
Tsitsilashvili, Elene et al.Myelin basic protein charge isomers change macrophage polarizationJournal of inflammation research2019
Wu, Xuping et al.Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cellsCancer Management and Research2019
Hu, Shuling et al.Mesenchymal Stem Cell Microvesicles Restore Protein Permeability Across Primary Cultures of Injured Human Lung Microvascular Endothelial CellsStem cells translational medicine2018
Roman-Garcia, Sara et al.Distinct roles for Bruton's Tyrosine Kinase in B cell immune synapse formationFrontiers in Immunology2018
Chen, Lihua et al.Smooth muscle-alpha actin inhibits vascular smooth muscle cell proliferation and migration by inhibiting rac1 activityPLoS ONE2016
Güntert, Tanja et al.Temporal Rac1 - HIF-1 crosstalk modulates hypoxic survival of aged neuronsBrain Research2016
Herrera-Martínez, Mayra et al.Antiamoebic activity of Adenophyllum aurantium (L.) strother and its effect on the actin cytoskeleton of Entamoeba histolyticaFrontiers in Pharmacology2016
Ahn, Bum Ju et al.Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamicsJournal of Biological Chemistry2014
Kalia, Manjula et al.Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic MechanismJournal of Virology2013
Teplova, Irina et al.ATG proteins mediate efferocytosis and suppress inflammation in mammary involutionAutophagy2013
Barrio, Laura et al.TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPasesThe Journal of Immunology2013
Dhaliwal, Anandika et al.Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPasesPLoS ONE2012
Ninkovi, Jana et al.Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanismsAmerican Journal of Pathology2012
Ridgway, Lon D. et al.Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cellsMolecular Cancer Research2012
Vives, Virginie et al.The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts2011
Halpert, Michal et al.Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanicaProtoplasma2011
May, James M.The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin CBritish Journal of Pharmacology2011
Lichtenstein, Mathieu P. et al.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivativesJournal of Alzheimer's disease : JAD2010
Johanna, Gutiérrez Vargas et al.Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemiaNeurochemistry international2010
Ridgway, Lon D. et al.Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma CellsJournal of cellular biochemistry2010
Romero, Ana M. et al.Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary cultureToxicological Sciences2010
Fang, Xiaohui et al.Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1Journal of Biological Chemistry2010
Zhu, Jianxin et al.P21-Activated Kinases Regulate Actin Remodeling in Glomerular PodocytesAmerican Journal of Physiology - Renal Physiology2010
Baumer, Y. et al.Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdownJournal of Cellular Physiology2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Mercer, Jason et al.Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cellsScience (New York, N.Y.)2008
Pontow, Suzanne et al.Antiviral Activity of a Rac GEF inhibitor Characterized with a Sensitive HIV/SIV Fusion AssayVirology2007
AuthorTitleJournalYearArticle Link
Morstein, Johannes et al.Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.Cell2024
Yin, Zhao et al.Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse modelInternational Journal of Biological Sciences2023
Hiatt, Susan M. et al.De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delayPLoS Genetics2018
Gu, Chunming et al.RalA, a GTPase targeted by miR‑181a, promotes transformation and progression by activating the Ras‑related signaling pathway in chronic myelogenous leukemiaOncotarget2016
Papini, Diana et al.TD-60 links RalA GTPase function to the CPC in mitosisNature Communications 2015 6:12015
AuthorTitleJournalYearArticle Link
Bergoug, Mohammed et al.An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site SelectionJournal of Molecular Biology2024
Puliga, Elisabetta et al.Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer modelsGastric Cancer2024
Popescu, Bogdan et al.Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AMLCell reports. Medicine2023
Li, Tianxia et al.Developing SHP2-based combination therapy for KRAS-amplified cancerJCI Insight2023
Baltanás, Fernando C. et al.Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinomaNature Communications2023
Peng, Ke et al.Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric CancerClinical Cancer Research2023
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Swaminathan, Bhairavi et al.Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migrationScientific Reports2022
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Mao, De Yu et al.CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and functionScience Signaling2021
Tisi, Renata et al.The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetux****-Resistant Cancer CellsFrontiers in Molecular Biosciences2021
Hofmann, Marco H. et al.Bi-3406, a potent and selective sos1–kras interaction inhibitor, is effective in kras-driven cancers through combined mek inhibitionCancer Discovery2021
Wang, Xuesong et al.Sevof****** inhibits growth factor-induced angiogenesis through suppressing Rac1/paxillin/FAK and Ras/Akt/mTORFuture oncology (London, England)2020
Kim, Jin Hee et al.Rational design of small molecule RHOA inhibitors for gastric cancerThe Pharmacogenomics Journal2020
Lu, Hengyu et al.Research paper resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFROncotarget2020
Morgan, Chase J. et al.Endogenous IQGAP1 and IQGAP3 do not functionally interact with RasScientific Reports2019
Casique-Aguirre, Diana et al.KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer 06 Biological Sciences 0601 Biochemistry and Cell BiologyBMC Cancer2018
Li, Qing fen et al.Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic StrokeCell Reports2018
Zhao, Tuo et al.Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 PathwaysInternational Journal of Molecular Sciences2018
Wong, Gabrielle S. et al.Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition letterNature Medicine2018
Chen, Guo Ping et al.Inhibition of farnesyl pyrophosphate synthase attenuates high glucose-induced vascular smooth muscle cells proliferationMolecular Medicine Reports2017
Huang, Jia Lin et al.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosisNature Communications2017
Zhao, Chen Ze et al.Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodelingScientific Reports2016
Lee, Sei Jung et al.Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5The Journal of Biological Chemistry2013
Camargo, Livia De Lucca et al.Endo-PDI is required for TNFα-induced angiogenesisFree Radical Biology and Medicine2013
Chen, Bin et al.Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fractionCellular Physiology and Biochemistry2013
Gil-Henn, H. et al.Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivoOncogene2013
AuthorTitleJournalYearArticle Link
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Sucre, Jennifer M.S. et al.Alveolar repair following LPS-induced injury requires cell-ECM interactionsJCI Insight2023
Zhu, Lingxin et al.Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorptionJournal of Cell Biology2023
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Hassin, Ori et al.Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patientsNature Communications2022
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Walter, Lisa Marie et al.Profilin2 regulates actin rod assembly in neuronal cellsScientific Reports2021
Rogg, Manuel et al.SRGAP1 controls small rho GTPases to regulate podocyte foot process maintenanceJournal of the American Society of Nephrology2021
Ghosh, Soma et al.PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFRCell Reports2021
Rodríguez-Fdez, Sonia et al.Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in LymphocytesCells2020
Hung, Pei Shan et al.The inhibition of Wnt restrain KRASG12V-driven metastasis in non-small-cell lung cancerCancers2020
Lorenzo-Martín, L. Francisco et al.VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinomaNature Communications2020
Lee, Mi Nam et al.The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activationStem Cell Research2020
Lorenzo-Martín, L. Francisco et al.Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factorOncogene2020
Atala, AnthonyRe: MicroRNA-141 Suppresses Prostate Cancer Stem Cells and Metastasis by Targeting a Cohort of Pro-Metastasis GenesThe Journal of urology2017
Cerikan, Berati et al.Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase RegulatorDevelopmental Cell2016
Sarowar, Tasnuva et al.Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2Molecular Brain2016
AuthorTitleJournalYearArticle Link
Wang, Li et al.Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylationJCI Insight2024
Xiao, Liyan et al.Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilamentsParticle and Fibre Toxicology2023
He, Yi et al.CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasisCell reports2023
Simonetti, Manuela et al.The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphologyMolecular Psychiatry2021
Lee, Sang Joon et al.AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defenceNature2021
Talamás-Lara, Daniel et al.Entamoeba histolytica and Entamoeba dispar: Morphological and Behavioral Differences Induced by Fibronectin through GTPases Activation and Actin-Binding ProteinsThe Journal of eukaryotic microbiology2020
Algaber, Anwar et al.MicroRNA-340-5p inhibits colon cancer cell migration via targeting of RhoAScientific Reports 2020 10:12020
dos Santos, Marlus Alves et al.Human B cells infected by Trypanosoma cruzi undergo F-actin disruption and cell death via caspase-7 activation and cleavage of phospholipase Cγ1Immunobiology2020
Elshaer, Sally L. et al.Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathwayDiabetologia2019
Wu, Xuping et al.Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cellsCancer Management and Research2019
Mei, Jie et al.A DAAM1 3′-UTR SNP mutation regulates breast cancer metastasis through affecting miR-208a-5p-DAAM1-RhoA axisCancer Cell International2019
Yan, Ting et al.Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cellsJournal of Biological Chemistry2018
Alizadeh, Javad et al.Detection of small gtpase prenylation and gtp binding using membrane fractionation and gtpase-linked immunosorbent assayJournal of Visualized Experiments2018
López-Contreras, Luilli et al.Structural and functional characterization of the divergent Entamoeba Src using Src inhibitor-1Parasites and Vectors2017
Paldy, Eszter et al.Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory painNature Communications2017
Ruggiero, Carmen et al.Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasionScience Signaling2017
Kim, Jongshin et al.YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturationJournal of Clinical Investigation2017
Itano, Seiji et al.Colch***** attenuates renal fibrosis in a murine unilateral ureteral obstruction modelMolecular Medicine Reports2017
Nour-Eldine, Wared et al.Adiponectin attenuates angiotensin II-induced vascular smooth muscle cell remodeling through nitric oxide and the RhoA/ROCK pathwayFrontiers in Pharmacology2016
Herrera-Martínez, Mayra et al.Antiamoebic activity of Adenophyllum aurantium (L.) strother and its effect on the actin cytoskeleton of Entamoeba histolyticaFrontiers in Pharmacology2016
Park, Yong Hwan et al.Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDSNature Immunology2016
Ajima, Rieko et al.DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assemblyDevelopmental Biology2015
Yan, Yi et al.Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5Nature Communications2015
Nakajima, Chikako et al.The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular developmentDevelopment (Cambridge)2014
Lasgorceix, M. et al.In vitro and in vivo evaluation of silicated hydroxyapatite and impact of insulin adsorptionJournal of Materials Science: Materials in Medicine2014
Moniz, Sónia et al.Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasivenessHuman molecular genetics2013
Bray, Kristi et al.Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migrationBreast Cancer Research2013
Veeramah, Krishna R. et al.Exome sequencing reveals new causal mutations in children with epileptic encephalopathiesEpilepsia2013
Bai, Xue et al.The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertensionNature Communications2013
Naraoka, Masato et al.Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in RabbitTranslational Stroke Research2013
Herrera-Martínez, M. et al.Actin, RhoA, and Rab11 participation during encystment in entamoeba invadensBioMed Research International2013
Nobe, Koji et al.Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A-Rho kinase signaling pathwayEuropean journal of pharmacology2012
Zuo, Yufeng et al.Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cellsJournal of cellular physiology2012
Wang, Jiping et al.RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular responseCardiovascular Diabetology2012
Doherty, Jason T. et al.Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating Protein (Rho-GAP), GRAFJournal of Biological Chemistry2011
Alvarez, S. M. et al.Failure of Bay K 8644 to induce RhoA kinase-dependent calcium sensitization in rabbit blood vesselsBritish journal of pharmacology2010
Hammar, Eva et al.Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic β-Cell FunctionEndocrinology2009
Heckman-Stoddard, Brandy M. et al.Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Moniz, Sónia et al.WNK2 modulates MEK1 activity through the Rho GTPase pathwayCellular signalling2008
Kinoshita, Nagatoki et al.Apical Accumulation of Rho in the Neural Plate Is Important for Neural Plate Cell Shape Change and Neural Tube FormationMolecular Biology of the Cell2008
Iesato, Ken et al.Tiotr***** bro**** attenuates respiratory syncytial virus replication in epithelial cellsRespiration; international review of thoracic diseases2008
Tanaka, Shigeru et al.Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowthThe Journal of biological chemistry2007
Schreibelt, Gerty et al.Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signalingFASEB journal2007
Scott, Glynis A. et al.Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activationThe Journal of investigative dermatology2007
Higashibata, Akira et al.Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation - Molecular cloning and sequencing of bovine leukemia-associated guanine nucleotide exchange factorBMC Biochemistry2006
Woods, Anita et al.RhoA/ROCK Signaling Regulates Chondrogenesis in a Context-dependent Manner *Journal of Biological Chemistry2006
AuthorTitleJournalYearArticle Link
Wang, Ting Ching et al.Genetic variation drives cancer cell adaptation to ECM stiffnessProceedings of the National Academy of Sciences2024
Wang, Hongyun et al.Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL PathwayAmerican Journal of Nephrology2024
Tokic, Silvija et al.The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial endothelial cells altered by gestational diabetes mellitusThe Journal of Physiology2024
Kim, Hugh et al.Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chainBiochemical Journal2024
Wang, Huogang et al.Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironmentExperimental Hematology & Oncology2024
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Kumari, Reena et al.Focal adhesions contain three specialized actin nanoscale layersNature Communications 2024
Koenis, Duco Steven et al.Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of GlycolysisAdvanced Science2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Vahldieck, Carl et al.Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axisFrontiers in Immunology2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Han, Xuedan et al.Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathwayJournal of Pharmaceutical Analysis2024
Zhang, Jiahui et al.Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoAPhytotherapy Research2024
Bock, Fabian et al.Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entryScience advances2024
Moztarzadeh, Sina et al.Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activationScientific Reports2024
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Yue, Xianlin et al.Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescenceCell Death Discovery2023
Safavian, Darya et al.Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zoneJournal of Cell Biology2023
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Huang, Xinyi et al.Actomyosin-dependent cell contractility orchestrates Zika virus infectionJournal of Cell Science2023
González, Yasmilde Rodríguez et al.PFTK1 kinase regulates axogenesis during development via RhoA activationBMC Biology2023
Ye, Qian et al.Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male miceNature Communications2023
Werder, Rhiannon B. et al.The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cellsAmerican journal of human genetics2023
Toffali, Lara et al.An isoform of the giant protein titin is a master regulator of human T lymphocyte traffickingCell reports2023
Bartos, Katalin et al.Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activityJournal of Cell Communication and Signaling2023
Escuin, Sarah et al.Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouseDMM Disease Models and Mechanisms2023
Dang, Iren et al.Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Journal of Cell Science2023
Martínez-Rendón, Jacqueline et al.Ouabain Induces Transcript Changes and Activation of RhoA/ROCK Signaling in Cultured Epithelial Cells (MDCK)Current Issues in Molecular Biology2023
Rogg, Manuel et al.A YAP/TAZ–ARHGAP29–RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin AdhesionsCells2023
Choi, Hyehun et al.LRRC8A anion channels modulate vascular reactivity via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)FASEB journal : official publication of the Federation of American Societies for Experimental Biology2023
Lopes-Rodrigues, Vanessa et al.AraC interacts with p75NTR transmembrane domain to induce cell death of mature neuronsCell Death & Disease2023
Zhai, Ruoyang et al.Effects of sevof****** on lung epithelial permeability in experimental models of acute respiratory distress syndromeJournal of Translational Medicine2023
Crespo, Grace Velez et al.The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancerMolecular Medicine2023
Morishita, Jun et al.Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cellsOpen Biology2023
Anastasaki, Corina et al.Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterizationSTAR Protocols2022
Zanin, Juan P. et al.p75NTR prevents the onset of cerebellar granule cell migration via RhoA activationeLife2022
Sánchez-de la Torre, Aníbal et al.Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in miceCell Death & Disease 2022 13:72022
Weder, Bruce et al.New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4Inflammatory Bowel Diseases2022
Yadav, Vikas et al.Increased MARCKS Activity in BRAF Inhibitor-Resistant Melanoma Cells Is Essential for Their Enhanced Metastatic Behavior Independent of Elevated WNT5A and IL-6 SignalingCancers2022
Kumar, Akhilesh et al.Essential role of Rnd1 in innate immunity during viral and bacterial infectionsCell Death & Disease 2022 13:62022
Wang, Kankai et al.PTBP1 knockdown promotes neural differentiation of glioblastoma cells through UNC5B receptorTheranostics2022
de Vallière, Cheryl et al.pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and FibrosisInternational Journal of Molecular Sciences2022
Meng, Zhipeng et al.The Hippo pathway mediates Semaphorin signalingScience Advances2022
Darp, Revati et al.Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesisNature Communications2022
Vadakumchery, Anila et al.The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B CellsFrontiers in Immunology2022
Hauke, Michael et al.Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial CellsJournal of the American Heart Association2022
Xue, Tan et al.Effects of Aster B-mediated intracellular accumulation of cholesterol on inflammatory process and myocardial cells in acute myocardial infarctionHellenic Journal of Cardiology2022
Francis, Caitlin R. et al.Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesisNature Communications 2022
Kumar, Akhilesh et al.Essential role of Rnd1 in innate immunity during viral and bacterial infectionsCell Death & Disease2022
Ma, Yuanyuan et al.Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root developmentDevelopment (Cambridge)2021
Jozic, Ivan et al.Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing woundsCommunications Biology2021
Porter, Lauren et al.SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle CellsCells2020
Krueger, Irena et al.Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPasesArteriosclerosis, Thrombosis, and Vascular Biology2020
Hasan, Wan Nuraini Wan et al.Annatto-derived tocotrienol promotes mineralization of MC3T3-E1 cells by enhancing BMP-2 protein expression via inhibiting RhoA activation and HMG-CoA reductase gene expressionDrug Design, Development and Therapy2020
Rong, Zhouyi et al.Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine modelsFASEB Journal2020
Lachowski, Dariusz et al.G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell PolarizationFrontiers in Cell and Developmental Biology2020
Dias Gomes, Martim et al.Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrityNature Communications2019
Santhana Kumar, Karthiga et al.TGF-β Determines the Pro-migratory Potential of bFGF Signaling in MedulloblastomaCell Reports2018
Patra, Vijay Kumar et al.The Skin Microbiome: Is It Affected by UV-induced Immune Suppression?Frontiers in Microbiology2016
Herr, Michael J. et al.Tetraspanin CD9 regulates cell contraction and actin arrangement via RhoA in human vascular smooth muscle cellsPLoS ONE2014
Biechler V., Stefanie V. et al.The impact of flow-induced forces on the morphogenesis of the outflow tractFrontiers in Physiology2014
Mackay, Joanna L. et al.Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promotersIntegrative Biology (United Kingdom)2014
Papke, Christina L. et al.Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-βHuman Molecular Genetics2013
Tan, Hong et al.Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valvesDevelopmental Biology2013
Kalia, Manjula et al.Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic MechanismJournal of Virology2013
Kanazawa, Yasushi et al.The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cellsExperimental neurology2013
Chen, Guang et al.Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2Journal of Biological Chemistry2012
Greco, Carolina M. et al.Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptorCardiovascular Research2012
Dhaliwal, Anandika et al.Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPasesPLoS ONE2012
Ramsay, Alan G. et al.Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancerBlood2012
Chen, Si Meng et al.Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTORBiochemical Pharmacology2012
Howe, Grant A. et al.RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoAVascular Cell2012
Yang, Seungwon et al.The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behaviorBiomaterials2012
Garrido‐Gómez, Tamara et al.Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F‐actin regulationThe FASEB Journal2012
Zhou, Zhigang et al.HSV-mediated gene transfer of C3 transferase inhibits Rho to promote axonal regenerationExperimental Neurology2012
McCoy, Kelly L. et al.Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loopCellular signalling2012
Ramseyer, Vanesa D. et al.Tumor necrosis factor α decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limbHypertension (Dallas, Tex. : 1979)2012
Jin, Wanzhu et al.Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistanceJournal of Clinical Investigation2011
Aguilar, Hector N. et al.Phos-tag-based analysis of myosin regulatory light chain phosphorylation in human uterine myocytesPLoS ONE2011
Ganguly, Riya et al.Adiponectin Increases LPL Activity via RhoA/ROCK-Mediated Actin Remodelling in Adult Rat CardiomyocytesEndocrinology2011
Musso, Alessandra et al.Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survivalHaematologica2011
Lichtenstein, Mathieu P. et al.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivativesJournal of Alzheimer's disease : JAD2010
Ridgway, Lon D. et al.Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma CellsJournal of cellular biochemistry2010
Rapier, Rebecca et al.The extracellular matrix microtopography drives critical changes in cellular motility and Rho A activity in colon cancer cellsCancer Cell International2010
Romero, Ana M. et al.Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary cultureToxicological Sciences2010
Nini, Lylia et al.Accurate and reproducible measurements of RhoA activation in small samples of primary cellsAnalytical biochemistry2010
Yang, Enyue et al.Fluoride induces vascular contraction through activation of RhoA/Rho kinase pathway in isolated rat aortasEnvironmental toxicology and pharmacology2010
Hammar, Eva et al.Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic β-Cell FunctionEndocrinology2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Seifert, Jennifer L. et al.Differential activation of Rac1 and RhoA in neuroblastoma cell fractionsNeuroscience letters2009
Ramirez, Servio H. et al.Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected MonocytesThe Journal of Immunology2008
Kinoshita, Nagatoki et al.Apical Accumulation of Rho in the Neural Plate Is Important for Neural Plate Cell Shape Change and Neural Tube FormationMolecular Biology of the Cell2008
Mercer, Jason et al.Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cellsScience (New York, N.Y.)2008
Sequeira, Linda et al.Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesisClinical & experimental metastasis2008
Moore, Simon W. et al.Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1Development2008
Korobova, Farida et al.Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cellsMolecular biology of the cell2008
Tanaka, Shigeru et al.Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowthThe Journal of biological chemistry2007
Schreibelt, Gerty et al.Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signalingFASEB journal2007
Keely, Patricia J. et al.Investigating integrin regulation and signaling events in three-dimensional systemsMethods in enzymology2007
AuthorTitleJournalYearArticle Link
Escuin, Sarah et al.Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouseDMM Disease Models and Mechanisms2023
Zhai, Ruoyang et al.Effects of sevof****** on lung epithelial permeability in experimental models of acute respiratory distress syndromeJournal of Translational Medicine2023
Lee, Sang Joon et al.AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defenceNature2021
Porter, Lauren et al.SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle CellsCells2020
Lachowski, Dariusz et al.G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell PolarizationFrontiers in Cell and Developmental Biology2020
Chronopoulos, Antonios et al.Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathwayNature Materials2020
Ngai, David et al.DDR1 (Discoidin Domain Receptor-1)-RhoA (Ras Homolog Family Member A) Axis Senses Matrix Stiffness to Promote Vascular CalcificationArteriosclerosis, Thrombosis, and Vascular Biology2020
Haq, Naila et al.Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neuronsPLoS Biology2019
Dér, Bálint et al.NK2 receptor-mediated detrusor muscle contraction involves Gq/11-dependent activation of voltage-dependent Ca2+ channels and the RhoA-Rho kinase pathwayAmerican Journal of Physiology - Renal Physiology2019
Peng, Jing Hua et al.Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat DietFrontiers in Pharmacology2018
Giannini, Marianna et al.Nano-topography: Quicksand for cell cycle progression?Nanomedicine: Nanotechnology, Biology, and Medicine2018
Zhang, Xiaoqing et al.Alterations of MEK1/2-ERK1/2, IFNγ and Smad2/3 associated Signalling pathways during cryopreservation of ASCs affect their differentiation towards VSMC-like cellsStem Cell Research2018
Tod, Jo et al.Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switchJournal of Pathology2017
Schillaci, Odessa et al.Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: Their emerging role in tumor heterogeneityScientific Reports2017
Kempf, Anissa et al.Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG InteractionDevelopmental Cell2017
Dyberg, Cecilia et al.Rho-associated kinase is a therapeutic target in neuroblastomaProceedings of the National Academy of Sciences of the United States of America2017
Yuan, Xue et al.Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiationNature Communications2016
Jiang, Lisheng et al.Selective activation of CB2 receptor improves efferocytosis in cultured macrophagesLife Sciences2016
Al-Shboul, OthmanThe role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contractionJournal of Physiological Sciences2016
Park, Yong Hwan et al.Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDSNature Immunology2016
Skrbic, Biljana et al.Lack of collagen VIII reduces fibrosis and promotes early mortality and cardiac dilatation in pressure overload in miceCardiovascular Research2015
Escuin, Sarah et al.Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closureJournal of Cell Science2015
Herr, Michael J. et al.Tetraspanin CD9 regulates cell contraction and actin arrangement via RhoA in human vascular smooth muscle cellsPLoS ONE2014
Biechler V., Stefanie V. et al.The impact of flow-induced forces on the morphogenesis of the outflow tractFrontiers in Physiology2014
Suen, J. Y. et al.Pathway-selective antagonism of proteinase activated receptor 2British Journal of Pharmacology2014
Tan, Hong et al.Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valvesDevelopmental Biology2013
Valtcheva, Nadejda et al.The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42Journal of Biological Chemistry2013
AuthorTitleJournalYearArticle Link
Bai, Xiaoyuan et al.The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumoniaMolecular Therapy2024
Ha, Cuong P. et al.Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progressionCell Death & Disease2024
Laurent-Issartel, Carine et al.Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrinsExperimental Cell Research2024
Guo, Xiong et al.Rabenosyn-5 suppresses non-small cell lung cancer metastasis via inhibiting CDC42 activityCancer Gene Therapy 2024
Yang, Ruicheng et al.Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coliCell Communication and Signaling2024
Tang, Jingshu et al.TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalizationThe Journal of Clinical Investigation2024
Aw, Wen Yih et al.Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationScience Advances2023
Fu, Lisheng et al.Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesionCell Death & Disease 2023 14:42023
Kim, Hyunsoo et al.PP2A-Mediated GSK3β Dephosphorylation Is Required for Protocadherin-7-Dependent Regulation of Small GTPase RhoA in OsteoclastsCells2023
Moreiras, Hugo et al.Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease-activated receptor-2 internalizationTraffic2022
Flores-Muñoz, Carolina et al.The Long-Term Pannexin 1 Ablation Produces Structural and Functional Modifications in Hippocampal NeuronsCells2022
Liu, Yao et al.Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularizationStem Cell Research and Therapy2021
Bian, Rui et al.Research paper rac gtpase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosisInternational Journal of Biological Sciences2021
Qi, Yan et al.Rhoa/rock pathway activation is regulated by at1 receptor and participates in smooth muscle migration and dedifferentiation via promoting actin cytoskeleton polymerizationInternational Journal of Molecular Sciences2020
Brisson, Lucie et al.P2X7 receptor promotes mouse mammary cancer cell invasiveness and tumour progression, and is a target for anticancer treatmentCancers2020
Frye, Maike et al.Ephrinb2-ephb4 signalling provides rho-mediated homeostatic control of lymphatic endothelial cell junction integrityeLife2020
Birkl, Dorothee et al.TNFα promotes mucosal wound repair through enhanced platelet activating factor receptor signaling in the epitheliumMucosal Immunology2019
Dupraz, Sebastian et al.RhoA Controls Axon Extension Independent of Specification in the Developing BrainCurrent Biology2019
Pan, Yu et al.Dissection of glomerular transcriptional profile in patients with diabetic nephropathy: SRGAP2a protects podocyte structure and functionDiabetes2018
Tang, Lian et al.RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via the JNK pathway and vimentin cytoskeletonPharmacological Research2018
Cheng, Lili et al.Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicityArchives of Toxicology2018
Tiwari, Richa et al.Depletion of keratin 8/18 modulates oncogenic potential by governing multiple signaling pathwaysFEBS Journal2018
Majumder, Piyali et al.Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenarioDMM Disease Models and Mechanisms2017
Li, Yan et al.Aerobic exercise regulates Rho/cofilin pathways to rescue synaptic loss in aged ratsPLoS ONE2017
Liu, Chunqiao et al.A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant colobomaHuman Molecular Genetics2016
Bon, Emeline et al.SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancerNature Communications2016
Zhang, Liang et al.A lateral signalling pathway coordinates shape volatility during cell migrationNature Communications2016
Medapati, Manoj Reddy et al.RAGE mediates the pro-migratory response of extracellular S100A4 in human thyroid cancer cellsThyroid2015
Tang, Jianjun et al.Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancerOncotarget2014
AuthorTitleJournalYearArticle Link
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Nawrotek, Agata et al.PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signalingNature Chemical Biology2019
Abdul-Salam, Vahitha B. et al.CLIC4/Arf6 Pathway: A New Lead in BMPRII Inhibition in Pulmonary HypertensionCirculation Research2019
Romani, Patrizia et al.Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBPNature Cell Biology2019
Yu, Qingfeng et al.A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostateJournal of Biological Chemistry2019
Sasai, Miwa et al.Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defenseNature Immunology2017
Ríos, Amelia et al.Participation of Rho, ROCK-2, and GAP activities during actin microfilament rearrangements in Entamoeba histolytica induced by fibronectin signalingCell Biology International2008
AuthorTitleJournalYearArticle Link
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Wang, Yilin et al.Cytohesin-2/ARNO: A Novel Bridge Between Cell Migration and Immunoregulation in Synovial FibroblastsFrontiers in Immunology2022
Oga, Takafumi et al.Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genesCancer science2019
Abdul-Salam, Vahitha B. et al.CLIC4/Arf6 Pathway: A New Lead in BMPRII Inhibition in Pulmonary HypertensionCirculation Research2019
Yu, Qingfeng et al.A NAV2729-sensitive mechanism promotes adrenergic smooth muscle contraction and growth of stromal cells in the human prostateJournal of Biological Chemistry2019
Früh, Simon et al.The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal culturesJournal of Neurochemistry2018
Krey, Jocelyn F. et al.ELMOD1 stimulates ARF6-GTP hydrolysis to stabilize apical structures in developing vestibular hair cellsJournal of Neuroscience2018
Herlemann, Annika et al.Inhibition of smooth muscle contraction and ARF6 activity by the inhibitor for cytohesin GEFs, secinH3, in the human prostateAmerican Journal of Physiology - Renal Physiology2018
Chen, Yu Ju et al.RAS SF4 controls SOCE and ER-PM junctions through regulation of PI(4,5)P2Journal of Cell Biology2017
Berg-Larsen, Axel et al.Differential Regulation of Rab GTPase Expression in Monocyte-Derived Dendritic Cells upon Lipopolysaccharide Activation: A Correlation to Maturation-Dependent Functional PropertiesPLoS ONE2013
Ríos, Amelia et al.Participation of Rho, ROCK-2, and GAP activities during actin microfilament rearrangements in Entamoeba histolytica induced by fibronectin signalingCell Biology International2008
AuthorTitleJournalYearArticle Link
Bai, Xiaoyuan et al.The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumoniaMolecular Therapy2024
Arnott, Malcolm et al.Transcription of microRNAs is regulated by developmental signaling pathways and transcription factorsFrontiers in Cell and Developmental Biology2024
Ha, Cuong P. et al.Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progressionCell Death & Disease2024
Laurent-Issartel, Carine et al.Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrinsExperimental Cell Research2024
Guo, Xiong et al.Rabenosyn-5 suppresses non-small cell lung cancer metastasis via inhibiting CDC42 activityCancer Gene Therapy 2024
Xu, Nana et al.CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activationNature Communications2024
Yang, Ruicheng et al.Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coliCell Communication and Signaling2024
Veloso, Alexandra et al.The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafishBMC Biology2024
Hu, Xinrong et al.A Natural Small Molecule Mitigates Kidney Fibrosis by Targeting Cdc42-mediated GSK-3β/β-catenin SignalingAdvanced Science2024
Chan, Chee Hong et al.Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 positionPLOS ONE2023
Aw, Wen Yih et al.Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationScience Advances2023
Newman, Daniel et al.3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migrationCell reports2023
Fang, Huan et al.Integrin β4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1eLife2023
Yang, Yuchen et al.β-hydroxybutyrate impairs the directionality of migrating neutrophils through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cowsJournal of Dairy Science2023
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Spel, Lotte et al.CDC42 regulates PYRIN inflammasome assemblyCell Reports2022
Khan, Alamzeb et al.ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leakFASEB journal2022
Li, Xiaopeng et al.Hhex inhibits cell migration via regulating RHOA/CDC42-CFL1 axis in human lung cancer cellsCell Communication and Signaling2021
Li, Chunsen et al.GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling PathwayFrontiers in Oncology2021
Zhou, Yongjie et al.Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liverTheranostics2021
McCray, Brett A. et al.Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extensionNature Communications2021
Chen, Lixia et al.CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathwaysTheranostics2020
Lian, Eric Y. et al.RET isoforms contribute differentially to invasive processes in pancreatic ductal adenocarcinomaOncogene2020
Zhang, Jiawei et al.In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and humanClinical and Translational Medicine2020
Hosseini, Kamran et al.EMT-Induced Cell-Mechanical Changes Enhance Mitotic Rounding StrengthAdvanced Science2020
Gu, Jiawen et al.Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42Experimental Cell Research2020
Lang, Yue et al.MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytesCell Death and Disease2019
Carvalho, J. R. et al.Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migrationeLife2019
Dagliyan, Onur et al.Engineering proteins for allosteric control by light or ligandsNature Protocols2019
Zhou, Yi Fan et al.Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by regulating endothelial DLL4 and filopodia formation in a rat model of ischemic strokeFASEB Journal2019
Liu, Chunxia et al.Epigenetically upregulated GEFT-derived invasion and metastasis of rhabdomyosarcoma via epithelial mesenchymal transition promoted by the Rac1/Cdc42-PAK signalling pathwayEBioMedicine2019
Yang, Huan et al.Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract InfectionsFrontiers in Immunology2018
Veluthakal, Rajakrishnan et al.Restoration of glucose-stimulated Cdc42-PAK1 activation and insulin secretion by a selective Epac activator in type 2 diabetic human isletsDiabetes2018
Sepúlveda-Ramírez, Silvia P. et al.Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryoDevelopmental Biology2018
Chavali, Manideep et al.Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelinationNature Communications2018
Sunkavalli, Ushasree et al.Analysis of host microRNA function uncovers a role for miR-29b-2-5p in Shigella capture by filopodiaPLoS Pathogens2017
Vidal-Quadras, Maite et al.Endocytic turnover of Rab8 controls cell polarizationJournal of Cell Science2017
Yao, Zhihui et al.P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 ActivationStem Cells and Development2017
Guo, Yaxiu et al.Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axisJournal of Pathology2017
Tormos, Ana M. et al.P38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and agingPLoS ONE2017
Saito, Masaki et al.Tctex‐1 controls ciliary resorption by regulating branched actin polymerization and endocytosisEMBO reports2017
Jia, L. et al.KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2Oncogene2016
Zhan, Rixing et al.Nitric oxide promotes epidermal stem cell migration via cGMP-Rho GTPase signallingScientific Reports2016
Moodley, Serisha et al.Stimulus-dependent dissociation between XB130 and Tks5 scaffold proteins promotes airway epithelial cell migrationOncotarget2016
Zhan, Rixing et al.Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signallingPLoS ONE2015
Ricotti, Leonardo et al.Boron nitride nanotube-mediated stimulation modulates F/G-actin ratio and mechanical properties of human dermal fibroblastsJournal of Nanoparticle Research2014
Tang, Xiaoyun et al.Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in miceJournal of Lipid Research2014
Knowles, Byron C. et al.Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion diseaseJournal of Clinical Investigation2014
Nithipatikom, Kasem et al.Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cellsEndocrinology2012
Sakabe, Isamu et al.Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cellsImmunity and Ageing2012
Asai, Akira et al.Involvement of Rac GTPase activation in phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to ICAM-1Biochemical and biophysical research communications2011
Nikolic, Damjan S. et al.HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagationBlood2011
Broman, Michael T. et al.Cdc42 regulates adherens junction stability and endothelial permeability by inducing α-catenin interaction with the vascular endothelial cadherin complexCirculation Research2006
Slice, Lee W. et al.Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathwaysThe Journal of biological chemistry2005
Nur-E-Kamal, Alam et al.Three dimensional nanofibrillar surfaces induce activation of RacBiochemical and biophysical research communications2005
Tang, Dale D. et al.The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscleJournal of Biological Chemistry2005
Chellaiah, Meenakshi A.Regulation of actin ring formation by Rho GTPases in osteoclastsJournal of Biological Chemistry2005
Sasai, Noriaki et al.The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movementsNature Cell Biol2004
Tang, Dale D. et al.The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscleJournal of Biological Chemistry2004
Liu, Xiu-Fen et al.Nucleotide Exchange Factor ECT2 Interacts with the Polarity Protein Complex Par6/Par3/Protein Kinase Cζ (PKCζ) and Regulates PKCζ ActivityMolecular and Cellular Biology2004
Vogl, Thomas et al.MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytesBlood2004
AuthorTitleJournalYearArticle Link
He, Ling et al.Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1Cancer research communications2024
Falace, Antonio et al.FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortexNeurobiology of Disease2024
Liu, Xiaomin et al.RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulationJournal of Virology2024
Oevel, Kristine et al.Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actineLife2024
Du, Xinyue et al.PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injuryNature Communications 2024 15:12024
Yau, Eric et al.SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophagesMicrobes and Infection2023
Ding, Jiuyang et al.Low and high dose methamphetamine differentially regulate synaptic structural plasticity in cortex and hippocampusFrontiers in Cellular Neuroscience2022
Posor, York et al.Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnoverDevelopmental Cell2022
Alalem, Mohamed et al.Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound PlumbaginCancers2022
Jiang, Lizhu et al.Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in RatsFrontiers in Molecular Neuroscience2022
Lei, Bo et al.Social experiences switch states of memory engrams through regulating hippocampal Rac1 activityProceedings of the National Academy of Sciences of the United States of America2022
Xu, Weiyi et al.Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrityMolecular biology of the cell2022
Afanasyeva, Elena A. et al.Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastomaLife Science Alliance2021
Ramírez-Ramírez, Danelia et al.Rac1 is necessary for capacitation and acrosome reaction in guinea pig spermatozoaJournal of cellular biochemistry2020
Lo, Louisa Hoi Ying et al.The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1 Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic Spine MaturationCell Reports2020
Balaji Ragunathrao, Vijay Avin et al.Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic SignalingCell Reports2019
Huang, Yuxing et al.Arp2/3-branched actin maintains an active pool of GTP-RhoA and controls RhoA abundanceCells2019
Lv, Li et al.Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memoryNature Communications2019
Wu, Wenjuan et al.Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s diseaseProtein and Cell2019
Wang, Jinyang et al.Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell MigrationInternational journal of molecular sciences2018
Liu, Yunlong et al.Social Isolation Induces Rac1-Dependent Forgetting of Social MemoryCell Reports2018
Morrison Joly, Meghan et al.Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasisBreast Cancer Research2017
Li, Shufeng et al.Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growthBiomaterials2015
Allison, Patrick et al.Type III TGFβ receptor and Src direct hyaluronan-mediated invasive cell motilityCellular Signalling2015
Mattias, Leino et al.The effects of artificial E-cadherin matrix-induced embryonic stem cell scattering on paxillin and RhoA activation via α-cateninBiomaterials2014
Castillo-Pichardo, Linette et al.Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice2013
Sabbatini, Maria Eugenia et al.Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 SignalingPLoS ONE2013
Gray, Jason D. et al.LRP6 exerts non-canonical effects on Wnt signaling during neural tube closureHuman Molecular Genetics2013
Zou, Wenying et al.AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cellsInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Ladhani, Omar et al.Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal ProteolysisNeoplasia (New York, N.Y.)2011
AuthorTitleJournalYearArticle Link
Bai, Xiaoyuan et al.The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumoniaMolecular Therapy2024
Ramos, Raquel et al.New Insights into the Exosome-Induced Migration of Uveal Melanoma Cells and the Pre-Metastatic Niche Formation in the LiverCancers2024
Ha, Cuong P. et al.Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progressionCell Death & Disease2024
Yau, Eric et al.SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophagesMicrobes and Infection2024
Voglewede, Mikayla M. et al.Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memoryiScience2024
He, Ling et al.Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1Cancer research communications2024
Falace, Antonio et al.FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortexNeurobiology of Disease2024
Laurent-Issartel, Carine et al.Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrinsExperimental Cell Research2024
Chen, Ye et al.Dynamic nanomechanical characterization of cells in exosome therapyMicrosystems & Nanoengineering 2024
Guo, Xiong et al.Rabenosyn-5 suppresses non-small cell lung cancer metastasis via inhibiting CDC42 activityCancer Gene Therapy 2024
Yang, Ruicheng et al.Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coliCell Communication and Signaling2024
Zhang, Huimin et al.PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older ageJCI Insight2024
Veloso, Alexandra et al.The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafishBMC Biology2024
Bahcheli, Alexander T. et al.Pan-cancer ion transport signature reveals functional regulators of glioblastoma aggressionThe EMBO journal2024
Chen, Weiwei et al.Tumour-associated macrophage-derived DOCK7-enriched extracellular vesicles drive tumour metastasis in colorectal cancer via the RAC1/ABCA1 axisClinical and Translational Medicine2024
Aljagthmi, Amjad A. et al.∆Np63α inhibits Rac1 activation and cancer cell invasion through suppression of PREX1Cell Death Discovery2024
Park, You Ri et al.Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migrationThe Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology2023
Liashkovich, Ivan et al.Pitstop-2 and its novel derivative RVD-127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPasesBioengineering & Translational Medicine2023
Aw, Wen Yih et al.Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationScience Advances2023
Dong, Yuqing et al.CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancerCancer Biology & Therapy2023
Takaya, Kento et al.Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPKBiomedicines2023
Koo, Tin Yan et al.N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomicsNature Communications2023
Newman, Daniel et al.3D matrix adhesion feedback controls nuclear force coupling to drive invasive cell migrationCell reports2023
Chen, Di et al.Knockdown of Porf-2 restores visual function after optic nerve crush injuryCell Death & Disease2023
Yu, Shuxiang et al.ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine PeritonitisInternational Journal of Molecular Sciences2023
Yang, Yuchen et al.β-hydroxybutyrate impairs the directionality of migrating neutrophils through inhibiting the autophagy-dependent degradation of Cdc42 and Rac1 in ketotic cowsJournal of Dairy Science2023
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Yau, Eric et al.SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophagesMicrobes and Infection2023
Wang, Yueyang et al.Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cellseLife2023
Morretton, Jean-Philippe et al.A catalog of numerical centrosome defects in epithelial ovarian cancersEMBO Molecular Medicine2022
Karthikeyan, Subbulakshmi et al.RAB4A GTPase regulates epithelial-to-mesenchymal transition by modulating RAC1 activationBreast Cancer Research2022
Singh, Neeraj et al.BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1Science Advances2022
Wang, Yuting et al.EPS8L1 promotes migration and metastasis of ovarian cancer by activating Rac1/MAPK signaling pathway via upregulating TIAM2Authorea Preprints2022
Adan, Hanad et al.Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblastsCancer Gene Therapy 2022 29:102022
Usuki, Seigo et al.Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte DifferentiationBiology2022
Adan, H et al.Activated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblastsCancer Gene …2022
Agbaegbu Iweka, Chinyere et al.The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory moleculesJournal of Neurochemistry2021
Masi, Ilenia et al.Endothelin-1 drives invadopodia and interaction with mesothelial cells through ILKCell Reports2021
Bai, Xiaoyuan et al.Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfectionCell Reports2021
Wang, Jiang Lin et al.Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal hornNeurobiology of Disease2021
Guo, Shuyu et al.Trio cooperates with Myh9 to regulate neural crest-derived craniofacial developmentTheranostics2021
Wang, Junyi et al.Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoACell Death and Disease2021
Zhou, Wenqing et al.Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeletonJournal of Cell Science2021
Shin, Seung Kak et al.Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signalingJournal of gastroenterology and hepatology2020
Benz, Peter M. et al.AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sproutingActa physiologica (Oxford, England)2020
Thamilselvan, Vijayalakshmi et al.P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-CellsCellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology2020
Li, Zean et al.The metastatic promoter DEPDC1B induces epithelial‐mesenchymal transition and promotes prostate cancer cell proliferation via Rac1‐PAK1 signalingClinical and Translational Medicine2020
Moody, Jasmine C. et al.The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cellsNature Communications2020
Danelon, Victor et al.Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite MorphogenesisJournal of Neuroscience2020
Larribère, Lionel et al.NF1-RAC1 axis regulates migration of the melanocytic lineageTranslational Oncology2020
Ichikawa, Takehiko et al.Non-junctional role of Cadherin3 in cell migration and contact inhibition of locomotion via domain-dependent, opposing regulation of Rac1Scientific Reports2020
Wei, Yiju et al. NEDD 4L‐mediated Merlin ubiquitination facilitates Hippo pathway activation EMBO reports2020
Aladowicz, Ewa et al.Shcd binds dock4, promotes ameboid motility and metastasis dissemination, predicting poor prognosis in melanomaCancers2020
Wang, Ruixiao et al.Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cellsLife Sciences2020
Smalley, Tracess et al.The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein ExpressionFrontiers in Oncology2020
Barabutis, Nektarios et al.Protective mechanism of the selective vas******** V1A receptor agonist selepressin against endothelial barrier dysfunctionJournal of Pharmacology and Experimental Therapeutics2020
Joshi, Rakesh et al.DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoAJournal of Biological Chemistry2020
Chen, Lixia et al.CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathwaysTheranostics2020
Amato, Clelia et al.WASP Restricts Active Rac to Maintain Cells’ Front-Rear PolarizationCurrent Biology2019
Tsygankova, Oxana M. et al.A unique role for clathrin light chain A in cell spreading and migrationJournal of Cell Science2019
Park, Jin Seok et al.Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPasesNature Communications2019
Liu, Yunlong et al.Social Isolation Induces Rac1-Dependent Forgetting of Social MemoryCell Reports2018
McQueeney, Kelley E. et al.Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitorOncotarget2018
Zago, Giulia et al.Ralb directly triggers invasion downstream ras by mobilizing the wave complexeLife2018
Barabutis, Nektarios et al.Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibitionJournal of Cellular and Molecular Medicine2018
Shi, Hao et al.Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory ActivityImmunity2018
Hayashi, Kentaro et al.Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulationScientific Reports2018
Shang, Wanjing et al.Genome-wide CRISPR screen identifies FAM49B as a key regulator of actin dynamics and T cell activationProceedings of the National Academy of Sciences of the United States of America2018
Wang, Yan et al.Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injectionBritish Journal of Pharmacology2016
Han, Jie et al.Farnesyl pyrophosphate synthase inhibitor, ibandronate, improves endothelial function in spontaneously hypertensive ratsMolecular Medicine Reports2016
Wang, Y. et al.Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864British Journal of Pharmacology2015
Wang, Shi Jie et al.CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cellsOncotarget2015
Hara, Yusuke et al.Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulationDevelopmental Biology2013
Han, Gangwen et al.Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositisNature Medicine2013
Geletu, M. et al.Classical cadherins control survival through the gp130/Stat3 axisBiochimica et Biophysica Acta - Molecular Cell Research2013
Zallocchi, Marisa et al.α1β1 Integrin/rac1-dependent mesangial invasion of glomerular capillaries in alport syndromeAmerican Journal of Pathology2013
Nithipatikom, Kasem et al.Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cellsEndocrinology2012
Lee, Wonhwa et al.Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal modelsToxicology and applied pharmacology2012
Ninkovi, Jana et al.Morphine decreases bacterial phagocytosis by inhibiting actin polymerization through cAMP-, Rac-1-, and p38 MAPK-dependent mechanismsAmerican Journal of Pathology2012
Wong, Hon Kit et al.Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanismNeoplasia2012
Gastonguay, Adam et al.The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinomaCancer Biology & Therapy2012
Syed, Ismail et al.L-threo-C 6 -pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cellsCellular Physiology and Biochemistry2012
Ock, Chan Young et al.A novel approach for stress-induced gastritis based on paradoxical anti-oxidative and anti-inflammatory action of exogenous 8-hydroxydeoxyguanosineBiochemical pharmacology2011
Garkavtsev, Igor et al.Dehydro-α-lapachone, a plant product with antivascular activityProceedings of the National Academy of Sciences of the United States of America2011
Souma, Tomokazu et al.Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cellsJournal of the American Society of Nephrology2011
Skalski, Michael et al.SNARE-mediated membrane traffic is required for focal adhesion kinase signaling and Src-regulated focal adhesion turnoverBiochimica et Biophysica Acta - Molecular Cell Research2011
Vidal-Quadras, Maite et al.Rac1 and Calmodulin Interactions Modulate Dynamics of ARF6-Dependent EndocytosisTraffic2011
Balanis, Nikolas et al.β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cellsMolecular Biology of the Cell2011
Jayaram, Bhavaani et al.Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cellsIslets2011
McAuley, Erin M. et al.Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migrationCell Adhesion and Migration2011
Kobayashi, Takashi et al.Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivoMolecular Endocrinology2010
Medhora, Meetha et al.20-HETE increases superoxide production and activates NAPDH oxidase in pulmonary artery endothelial cellsAmerican Journal of Physiology - Lung Cellular and Molecular Physiology2008
Bergstrom, R. A. et al.Agrin induced morphological and structural changes in growth cones of cultured hippocampal neuronsNeuroscience2007
Wang, Guoyan et al.Genetic ablation of Rac1 in cartilage results in chondrodysplasiaDevelopmental Biology2007
Slice, Lee W. et al.Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathwaysThe Journal of biological chemistry2005
Sasai, Noriaki et al.The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movementsNature Cell Biol2004
Yang, Seun Ah et al.Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in plateletsJournal of Biological Chemistry2004
Zhang, Yongjun et al.Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survivalThe Journal of biological chemistry2004
Chromy, Brett A. et al.Self-assembly of Abeta(1-42) into globular neurotoxinsBiochemistry2003
Quadri, Sadiqa K. et al.Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase *Journal of Biological Chemistry2003
AuthorTitleJournalYearArticle Link
Han, David et al.The RAL Small G Proteins Are Clinically Relevant Targets in Triple Negative Breast CancerCancers2024
Long, Yufei et al.FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancerJournal of Experimental and Clinical Cancer Research2022
AuthorTitleJournalYearArticle Link
Han, David et al.The RAL Small G Proteins Are Clinically Relevant Targets in Triple Negative Breast CancerCancers2024
Wang, Xuan et al.Triple Blockade of Oncogenic RAS Signaling Using KRAS and MEK Inhibitors in Combination with Irradiation in Pancreatic CancerInternational Journal of Molecular Sciences2024
Consalvo, Kristen M. et al.PTEN and the PTEN-like phosphatase CnrN have both distinct and overlapping roles in a Dictyostelium chemorepulsion pathwayJournal of Cell Science2024
Carrión-Estrada, Dayan A. et al.Antineoplastic effect of compounds C14 and P8 on TNBC and radioresistant TNBC cells by stabilizing the K-Ras4BG13D/PDE6δ complexFrontiers in Oncology2024
Najumudeen, Arafath K. et al.KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivoNature Communications2024
Orecchini, E. et al.The signaling function of IDO1 incites the malignant progression of mouse B16 melanomaOncoImmunology2023
Jin Cho, S et al.Rab25 suppresses colon cancer cell invasion through upregulating claudin‑7 expressionOncology Reports2023
Ravishankar, Rajani et al.Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and FunctionMicrobiology Spectrum2023
Rubio, Karla et al.Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancerTheranostics2023
Prahallad, Anirudh et al.CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung CancerCancer research2023
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Bortolami, Alessandro et al.Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsyCell Death & Differentiation2022
Cruz-Nova, Pedro et al.131I-C19 Iodide Radioisotope and Synthetic I-C19 Compounds as K-Ras4B–PDE6δ Inhibitors: A Novel Approach against Colorectal Cancer—Biological Characterization, Biokinetics and DosimetryMolecules2022
Zhu, Dantong et al.Loss of PTEN-Induced Kinase 1 Regulates Oncogenic Ras-Driven Tumor Growth By Inhibiting Mitochondrial FissionFrontiers in Oncology2022
Carnevale, Julia et al.RASA2 ablation in T cells boosts antigen sensitivity and long-term functionNature2022
Jeon, So Mi et al.Blockade of PD-L1/PD-1 signaling promotes osteo-/odontogenic differentiation through Ras activationInternational Journal of Oral Science2022
Song, Dan et al.NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular CarcinomaGenomics, Proteomics & Bioinformatics2022
Kirolos, Sara A. et al.A chemorepellent inhibits local Ras activation to inhibit pseudopod formation to bias cell movement away from the chemorepellentMolecular biology of the cell2022
Ablain, Julien et al.SPRED1 deletion confers resistance to MAPK inhibition in melanomaThe Journal of experimental medicine2021
Tulpule, Asmin et al.Kinase-mediated RAS signaling via membraneless cytoplasmic protein granulesCell2021
Wiley, Christopher D. et al.Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysisCell Metabolism2021
Yan, Wupeng et al.Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFRCell Reports2020
Brandt, Raphael et al.Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumNature Communications2019
Hood, Fiona E. et al.Isoform-specific Ras signaling is growth factor dependentMolecular Biology of the Cell2019
Rijal, Ramesh et al.An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cellsMolecular Biology of the Cell2019
Cai, Diana et al.Identification and characterization of oncogenic SOS1 mutations in lung adenocarcinomaMolecular Cancer Research2019
Pilling, Darrell et al.Different Isoforms of the Neuronal Guidance Molecule Slit2 Directly Cause Chemoattraction or Chemorepulsion of Human NeutrophilsThe Journal of Immunology2019
Cocco, Emiliano et al.Resistance to TRK inhibition mediated by convergent MAPK pathway activationNature Medicine2019
Dardaei, Leila et al.SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitorsNature Medicine2018
Saikia, Minakshi et al.Heteronemin, a marine natural product, sensitizes acute myeloid leukemia cells towards cytar***** chemotherapy by regulating farnesylation of RasOncotarget2018
Smolkin, Tatyana et al.Complexes of plexin-A4 and plexin-D1 convey semaphorin-3C signals to induce cytoskeletal collapse in the absence of neuropilinsJournal of Cell Science2018
Whiteside, Theresa L.Therapeutic targeting of oncogenic KRAS in pancreatic cancer by engineered exosomesTranslational Cancer Research2017
Malchers, Florian et al.Mechanisms of primary drug resistance in FGFR1-amplified lung cancerClinical Cancer Research2017
Lu, Xinyuan et al.MET exon 14 mutation encodes an actionable therapeutic target in lung adenocarcinomaCancer Research2017
Walton, Josephine B. et al.CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivityScientific Reports2017
Ilinskaya, Olga N. et al.Direct inhibition of oncogenic KRAS by Bacillus pumilus ribonuclease (binase)Biochimica et Biophysica Acta - Molecular Cell Research2016
Larribere, Lionel et al.NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based modelPigment Cell and Melanoma Research2015
Hrustanovic, Gorjan et al.RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancerNature Medicine2015
Yan, Chao et al.Discovery and characterization of small molecules that target the GTPase RalNature2014
Du, Chang Qing et al.Inhibition of farnesyl pyrophosphate synthase prevents norep*********- induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive ratsHypertension Research2014
Ciaglia, Elena et al.N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulationJournal of Leukocyte Biology2013
Kern, F. et al.Essential, non-redundant roles of B-Raf and Raf-1 in Ras-driven skin tumorigenesisOncogene2012
Stoppa, Giovanna et al.Ras signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cellsApoptosis : an international journal on programmed cell death2012
Jiang, Xiao Sheng et al.Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implicationsHuman molecular genetics2010
Kowluru, Renu A.Role of Matrix Metalloproteinase-9 in the Development of Diabetic Retinopathy and Its Regulation by H-RasInvestigative Ophthalmology & Visual Science2010
Lito, Piro et al.Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblastsThe Journal of biological chemistry2008
Wasylyk, Christine et al.Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubulesCancer Research2008
AuthorTitleJournalYearArticle Link
Chen, Xiuzhen et al.The FXR1 network acts as a signaling scaffold for actomyosin remodelingCell2024
Olivier, Jean Frederic et al.CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic cell function in neuroinflammation and colitisCommunications Biology2024
Ye, Junjie et al.RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesisCellular Signalling2024
Bai, Xiaoyuan et al.The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumoniaMolecular Therapy2024
Ramos, Raquel et al.New Insights into the Exosome-Induced Migration of Uveal Melanoma Cells and the Pre-Metastatic Niche Formation in the LiverCancers2024
Ha, Cuong P. et al.Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progressionCell Death & Disease2024
Jinsheng, Li et al.Micro/nano topological modification of TiO2 nanotubes activates Thy-1 signaling to control osteogenic differentiation of stem cellsSLAS Discovery2024
Gan, Wan J. et al.A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tensionCytoskeleton2024
Wei, Zhewei et al.DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF-1α Ubiquitination and DegradationAdvanced Science2024
Laurent-Issartel, Carine et al.Ascites microenvironment conditions the peritoneal pre-metastatic niche to promote the implantation of ovarian tumor spheroids: Involvement of fibrinogen/fibrin and αV and α5β1 integrinsExperimental Cell Research2024
Akhter, Md Zahid et al.FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activityCell Reports2024
Liu, Yuhan et al.Isoform-independent promotion of contractility and proliferation, and suppression of survival by with no lysine/K kinases in prostate stromal cellsThe FASEB Journal2024
Chen, Ye et al.Dynamic nanomechanical characterization of cells in exosome therapyMicrosystems & Nanoengineering 2024
Chen, Xiaoqing et al.ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK SignalingFrontiers in Bioscience - Landmark2024
Guo, Xiong et al.Rabenosyn-5 suppresses non-small cell lung cancer metastasis via inhibiting CDC42 activityCancer Gene Therapy 2024
Gandhi, Nisha et al.In Vitro Cell Culture Model for Osteoclast Activation during Estrogen WithdrawalInternational Journal of Molecular Sciences2024
Yang, Ruicheng et al.Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coliCell Communication and Signaling2024
Veloso, Alexandra et al.The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafishBMC Biology2024
Yao, Na et al.An emerging role of arecoline on growth performance, intestinal digestion and absorption capacities and intestinal structural integrity of adult grass carp (Ctenopharyngodon idella)Animal Nutrition2023
Freiberg, Fabian et al.CAR links hypoxia signaling to improved survival after myocardial infarctionExperimental & Molecular Medicine2023
Aw, Wen Yih et al.Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formationScience Advances2023
Dong, Yuqing et al.CCL2 promotes lymphatic metastasis via activating RhoA and Rac1 pathway and predict prognosis to some extent in tongue cancerCancer Biology & Therapy2023
Lin, Xixi et al.Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic miceRespiratory Research2023
Wang, Jirong et al.RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signalingMolecular Medicine2023
Zhang, Shuang et al.Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cellsCellular and Molecular Life Sciences2023
Zhang, Tao et al.Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axisCell Communication and Signaling2023
Zhang, Yaping et al.Integrin β3 directly inhibits the Gα13-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosisNature Communications 2023
Danielson, Laura S. et al.MiR-130b modulates the invasive, migratory, and metastatic behavior of leiomyosarcomaPLOS ONE2023
Ravn-Boess, Niklas et al.The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerabilityCell reports2023
Cittadini, Camilla et al.Effects of the Rho GTPase-activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot studyJournal of Cellular and Molecular Medicine2023
Knop, Juna Lisa et al.Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signalingiScience2023
Mobley, James A. et al.The SARS-CoV-2 spike S1 protein induces global proteomic changes in ATII-like rat L2 cells that are attenuated by hyaluronanAmerican Journal of Physiology - Lung Cellular and Molecular Physiology2023
Serwe, Guillaume et al.CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature Communications2023
Oh, Mijung et al.High extracellular glucose promotes cell motility by modulating cell deformability and contractility via the cAMP-RhoA-ROCK axis in human breast cancer cellsMolecular Biology of the Cell2023
Wang, Yueyang et al.Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cellseLife2023
Spel, Lotte et al.CDC42 regulates PYRIN inflammasome assemblyCell Reports2022
Zheng, Cankun et al.CX3CL1 Worsens Cardiorenal Dysfunction and Serves as a Therapeutic Target of Canag******** for Cardiorenal SyndromeFrontiers in Pharmacology2022
Hamuro, Junji et al.Repressed miR-34a Expression Dictates the Cell Fate to Corneal Endothelium FailureInvestigative Ophthalmology & Visual Science2022
Rackow, Ashley R. et al.The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA ActivityInternational Journal of Molecular Sciences2022
Vittoria, Marc A. et al.Inactivation of the Hippo tumor suppressor pathway promotes melanomaNature Communications2022
Usuki, Seigo et al.Konjac Ceramide (kCer)-Mediated Signal Transduction of the Sema3A Pathway Promotes HaCaT Keratinocyte DifferentiationBiology2022
Yokoyama, Yusuke et al.Crumbs3 is expressed in oral squamous cell carcinomas and promotes cell migration and proliferation by affecting RhoA activityOncology Letters2022
Swiatlowska, Pamela et al.Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switchingScience Advances2022
Mahly, Adnan et al.Anillin governs mitotic rounding during early epidermal developmentBMC Biology2022
Shin, Yuna et al.NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP SignalingCancers2022
Almarán, Beatriz et al.Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase SignallingCells2022
Soda, Tomohiro et al.Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomachScientific Reports 2022 12:12022
Qian, Zhanyang et al.Activation of gluc****-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injuryInternational Journal of Biological Sciences2022
Loria, Rossella et al.SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanomaJournal of Experimental and Clinical Cancer Research2022
Kholmanskikh, Stanislav et al.Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1Scientific Reports 2022 12:12022
Agbaegbu Iweka, Chinyere et al.The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory moleculesJournal of Neurochemistry2021
Rolle, Irene Giulia et al.Heart failure impairs the mechanotransduction properties of human cardiac pericytesJournal of Molecular and Cellular Cardiology2021
Miao, Chunhui et al.An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coliNature Communications2021
Guo, Shuyu et al.Trio cooperates with Myh9 to regulate neural crest-derived craniofacial developmentTheranostics2021
Wang, Junyi et al.Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoACell Death and Disease2021
Zhan, Fangbiao et al.RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathwayCell and Bioscience2021
Ramírez-Ramírez, Danelia et al.Rac1 is necessary for capacitation and acrosome reaction in guinea pig spermatozoaJournal of cellular biochemistry2020
Guo, Yaxiu et al.Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoCFASEB Journal2020
Moodley, Serisha et al.RET isoform-specific interaction with scaffold protein Ezrin promotes cell migration and chemotaxis in lung adenocarcinomaLung cancer (Amsterdam, Netherlands)2020
Wang, Ruixiao et al.Rac1 silencing, NSC23766 and EHT1864 reduce growth and actin organization of bladder smooth muscle cellsLife Sciences2020
Barabutis, Nektarios et al.Protective mechanism of the selective vas******** V1A receptor agonist selepressin against endothelial barrier dysfunctionJournal of Pharmacology and Experimental Therapeutics2020
Hellinger, Johanna W. et al.Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signalingScientific Reports2020
Wang, Xiaobo et al.Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic SteatohepatitisCell Metabolism2020
Grun, Daniel et al.NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survivalMolecular Carcinogenesis2019
Jiao, Yi et al.Mechanism of H2S‑mediated ROCK inhibition of total flavones of Rhododendra against myocardial ischemia injuryExperimental and Therapeutic Medicine2019
Ma, Teng jiao et al.CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cellsExperimental and Molecular Medicine2018
Zhang, Xin et al.Fasudil increases temoz******* sensitivity and suppresses temoz*******-resistant glioma growth via inhibiting ROCK2/ABCG2Cell Death and Disease2018
Lehman, Heather L. et al.NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulationOncotarget2018
Goodman, Linda et al.Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cellsJournal of Cell Science2017
Islam, Salman Ul et al.PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transitionOncotarget2017
Cho, Soo Young et al.Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset CancersGastroenterology2017
Watts, Bruns A. et al.High-mobility group box 1 inhibits HCO3_ absorption in the medullary thick ascending limb through RAGE-rho-ROCK-mediated inhibition of basolateral Na+/H+ exchangeAmerican Journal of Physiology - Renal Physiology2016
Gilbert, James et al.The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin and δ-catenin signalingeNeuro2016
Wang, Y. et al.Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864British Journal of Pharmacology2015
Su, Chien Chia et al.Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective rho kinase inhibitor, Y-27632Molecular Vision2015
Wang, Shi Jie et al.CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cellsOncotarget2015
Yan, Chao et al.Discovery and characterization of small molecules that target the GTPase RalNature2014
Stankiewicz, Trisha R. et al.Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegenerationFrontiers in Cellular Neuroscience2014
Tong, Jing et al.Activation of RhoA in Alcohol-Induced Intestinal Barrier DysfunctionInflammation2013
Zhan, Hong et al.The effect of an NgR1 antagonist on the neuroprotection of cortical axons after cortical infarction in ratsNeurochemical Research2013
Xie, Xi et al.Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathyMolecular and cellular endocrinology2013
Hara, Yusuke et al.Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulationDevelopmental Biology2013
Nithipatikom, Kasem et al.Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cellsEndocrinology2012
Lee, Wonhwa et al.Barrier protective effects of withaferin A in HMGB1-induced inflammatory responses in both cellular and animal modelsToxicology and applied pharmacology2012
Li, B. et al.RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cellsOncogene2012
Cheng, Haoran et al.Infrasonic noise induces axonal degeneration of cultured neurons via a Ca²⁺ influx pathwayToxicology letters2012
Gastonguay, Adam et al.The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinomaCancer Biology & Therapy2012
Tsuboi, Naoko et al.The effect of monocyte chemoattractant protein-1/CC chemokine ligand 2 on aqueous humor outflow facilityInvestigative Ophthalmology and Visual Science2012
Khan, Omar M. et al.Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in miceJournal of Clinical Investigation2011
Hu, Yi et al.Effects of ischemic preconditioning on vascular reactivity and calcium sensitivity after hemorrhagic shock and their relationship to the RhoA–Rho-kinase pathway in ratsJournal of cardiovascular pharmacology2011
Balanis, Nikolas et al.β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cellsMolecular Biology of the Cell2011
Ríos, Amelia et al.Participation of Rho, ROCK-2, and GAP activities during actin microfilament rearrangements in Entamoeba histolytica induced by fibronectin signalingCell Biology International2008
Cheng, Zhi Jie et al.Distinct mechanisms of clathrin-independent endocytosis have unique sphingolipid requirementsMolecular Biology of the Cell2006
Pixley, Fiona J. et al.BCL6 suppresses RhoA activity to alter macrophage morphology and motilityJournal of cell science2005
Sasai, Noriaki et al.The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movementsNature Cell Biol2004
Yang, Seun Ah et al.Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in plateletsJournal of Biological Chemistry2004
Orr, Anthony Wayne et al.Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion DisassemblyJournal of Biological Chemistry2004
Cetin, Selma et al.Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesionsThe Journal of biological chemistry2004
Birukova, Anna A. et al.Protein kinase A attenuates endothelial cell barrier dysfunction induced by microtubule disassemblyAmerican journal of physiology. Lung cellular and molecular physiology2004
Setiadi, Hendra et al.Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flowJournal of Cell Biology2003
AuthorTitleJournalYearArticle Link
Wilson, Zachary S. et al.Critical role of thrombospondin-1 in promoting intestinal mucosal wound repairJCI Insight2024
Peng, Yundong et al.RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell lossCell Discovery2024
Oevel, Kristine et al.Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actineLife2024
Morel, Anne et al.Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1Frontiers in Physiology2024
Ren, Xiaoyu et al.Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxisEMBO Reports2024
Samain, Remi et al.CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cellsScience Advances2023
Wong, Darren Chen Pei et al.Hiltonol, a dsRNA Mimic, Promotes NK Cell Anticancer Cytotoxicity Through TAZ Cytoplasmic SequestrationAdvanced Therapeutics2023
Zhang, Xingyu et al.Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s diseaseNature Communications2023
Morishita, Jun et al.Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cellsOpen Biology2023
Leguay, Kévin et al.Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entryJournal of Cell Biology2022
Khan, Alamzeb et al.ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leakFASEB journal2022
You, Jae Sung et al.ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through AutophagyCell Reports2021
Afanasyeva, Elena A. et al.Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastomaLife Science Alliance2021
Evans, Frances et al.Signaling pathways in cytoskeletal responses to plasma membrane depolarization in corneal endothelial cellsJournal of Cellular Physiology2020
Addis, Dylan R. et al.Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposureAmerican Journal of Physiology - Lung Cellular and Molecular Physiology2020
Liang, Xiaoting et al.Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in OsteosarcomaTheranostics2020
Huang, Yuxing et al.Arp2/3-branched actin maintains an active pool of GTP-RhoA and controls RhoA abundanceCells2019
Choi, Michael Y. et al.Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic LeukemiaCell Stem Cell2018
Yu, Lixia et al.C-Maf inducing protein inhibits coflin-1 activity and alters podocyte cytoskeleton organizationMolecular Medicine Reports2017
Kempf, Anissa et al.Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG InteractionDevelopmental Cell2017
Li, Shufeng et al.Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growthBiomaterials2015
Sabbatini, Maria Eugenia et al.Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 SignalingPLoS ONE2013
Gray, Jason D. et al.LRP6 exerts non-canonical effects on Wnt signaling during neural tube closureHuman Molecular Genetics2013
Xu, Jie et al.RhoGAPs Attenuate Cell Proliferation by Direct Interaction with p53 Tetramerization DomainCell Reports2013
Buranda, Tione et al.Rapid parallel flow cytometry assays of active GTPases using effector beadsAnalytical Biochemistry2013
Zhang, Y. et al.High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generationAmerican journal of physiology. Renal physiology2012
Kyrkou, A. et al.RhoD participates in the regulation of cell-cycle progression and centrosome duplicationOncogene 2013 32:142012
Cartier-Michaud, Amandine et al.Matrix-bound PAI-1 supports cell blebbing via RhoA/rock1 signalingPLoS ONE2012
Ponsaerts, Raf et al.RhoA GTPase switch controls Cx43-hemichannel activity through the contractile systemPLoS ONE2012
Ladhani, Omar et al.Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal ProteolysisNeoplasia (New York, N.Y.)2011
Chacon, Pedro J. et al.Inhibition of RhoA GTPase and the subsequent activation of PTP1B protects cultured hippocampal neurons against amyloid β toxicityMolecular Neurodegeneration2011
Wang, Shizhen Emily et al.Transforming Growth Factor β (TGF-β)-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-β FunctionMolecular and Cellular Biology2005
Ishii, Satoshi et al.Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptorThe Journal of biological chemistry2005
Bi, Yan et al.A role for Rho and Rac in secretagogue-induced amylase release by pancreatic aciniAmerican journal of physiology. Cell physiology2005
Wang, Qin et al.Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cellsThe Journal of biological chemistry2004
Saito, Shin'ichi et al.Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformationThe Journal of biological chemistry2004
Zhang, Xiao Feng et al.Rho-Dependent Contractile Responses in the Neuronal Growth Cone Are Independent of Classical Peripheral Retrograde Actin FlowNeuron2003