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Author | Title | Journal | Year | Article Link |
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Gao, Fei et al. | STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cells | OncoTargets and Therapy | 2018 | |
Rafiq, Nisha Bte Mohd et al. | Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO | The Journal of cell biology | 2017 | |
Rennoll-Bankert, Kristen E. et al. | RalF-Mediated Activation of Arf6 ControlsRickettsia typhiInvasionby Co-Opting Phosphoinositol Metabolism | Infect Immun | 2016 | |
Schultz, Mark L. et al. | CLN3 Deficient Cells Display Defects in the ARF1-Cdc42 Pathway and Actin-Dependent Events | PLOS ONE | 2014 |
Author | Title | Journal | Year | Article Link |
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Borghesan, Elizabeth et al. | A Brucella effector modulates the Arf6‐Rab8a GTPase cascade to promote intravacuolar replication | The EMBO Journal | 2021 | |
Jackson, Matilda R. et al. | Heterozygous loss of function of IQSEC2/Iqsec2 leads to increased activated Arf6 and severe neurocognitive seizure phenotype in females | Life Science Alliance | 2019 | |
Rafiq, Nisha Bte Mohd et al. | Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO | The Journal of cell biology | 2017 | |
Stepicheva, Nadezda A. et al. | The small GTPase Arf6 regulates sea urchin morphogenesis | Differentiation; research in biological diversity | 2017 | |
Biesemann, Anja et al. | Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies | The Journal of biological chemistry | 2017 | |
Rennoll-Bankert, Kristen E. et al. | RalF-Mediated Activation of Arf6 ControlsRickettsia typhiInvasionby Co-Opting Phosphoinositol Metabolism | Infect Immun | 2016 | |
Andrews, Allison M. et al. | Mechanical Injury Induces Brain Endothelial-Derived Microvesicle Release: Implications for Cerebral Vascular Injury during Traumatic Brain Injury | Frontiers in Cellular Neuroscience | 2016 | |
Marchesin, Valentina et al. | ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-Actin rosettes in breast cancer cells in response to epidermal growth factor | PLoS ONE | 2015 |
Author | Title | Journal | Year | Article Link |
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Ji, Juanjuan et al. | TMEM16A enhances the activity of the Cdc42-NWASP signaling pathway to promote invasion and metastasis in oral squamous cell carcinoma | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology | 2024 | |
Szigeti, Kinga et al. | CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization | eBioMedicine | 2024 | |
Mendoza-Soto, Pablo et al. | Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes | Cells | 2024 | |
Wu, Fei et al. | Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight | Nature Communications | 2024 | |
Lee, Choong Jae et al. | The dysadherin/FAK axis promotes individual cell migration in colon cancer | International Journal of Biological Sciences | 2024 | |
Liang, Bishan et al. | Cdc42-driven endosomal cholesterol transport promotes collateral resistance in HER2-positive gastric cancer | Cancer Letters | 2024 | |
Adhicary, Subhodip et al. | Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation | Stroke | 2023 | |
Szigeti, Kinga et al. | Neuronal actin cytoskeleton gain of function in the human brain | eBioMedicine | 2023 | |
Xie, Wangkai et al. | ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer | Cell Death & Disease | 2023 | |
Punessen, Noelle C. et al. | A novel anti-apoptotic role for Cdc42/ACK-1 signaling in neurons | Molecular and Cellular Neuroscience | 2023 | |
St. Paul, Amanda et al. | FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms | Cell reports | 2023 | |
Castillo-Azofeifa, David et al. | A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling | Cell stem cell | 2023 | |
Crespo, Grace Velez et al. | The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer | Molecular Medicine | 2023 | |
Adhicary, Subhodip et al. | Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation | Stroke | 2023 | |
Zi, Jingjing et al. | PFN1 Inhibits Myogenesis of Bovine Myoblast Cells via Cdc42-PAK/JNK | Cells | 2022 | |
Meng, Zhipeng et al. | The Hippo pathway mediates Semaphorin signaling | Science Advances | 2022 | |
Jiang, Ruiwei et al. | CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport | Cell Death & Disease | 2022 | |
Ma, Yuanyuan et al. | Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development | Development (Cambridge) | 2021 | |
Jozic, Ivan et al. | Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing wounds | Communications Biology | 2021 | |
Vallejo, Daniela et al. | Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons | Journal of Neurochemistry | 2021 | |
Wurzer, Hannah et al. | Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling | Frontiers in Immunology | 2021 | |
Merlin, Johanna et al. | Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation | Nature Metabolism | 2021 | |
Lee, Daniel | miR‑769‑5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells | Experimental and Therapeutic Medicine | 2021 | |
Salameh, Joëlle et al. | Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubules | Current Biology | 2021 | |
Talamás-Lara, Daniel et al. | Entamoeba histolytica and Entamoeba dispar: Morphological and Behavioral Differences Induced by Fibronectin through GTPases Activation and Actin-Binding Proteins | The Journal of eukaryotic microbiology | 2020 | |
Krueger, Irena et al. | Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPases | Arteriosclerosis, Thrombosis, and Vascular Biology | 2020 | |
Rong, Zhouyi et al. | Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models | FASEB Journal | 2020 | |
Andrews, Madeline G. et al. | Mtor signaling regulates the morphology and migration of outer radial glia in developing human cortex | eLife | 2020 | |
Choraghe, Rohan P. et al. | RHOA-mediated mechanical force generation through Dectin-1 | Journal of cell science | 2020 | |
Malek, Natalia et al. | Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) technique shows that non-muscle β and γ actin are not equal in relation to human melanoma cells’ motility and focal adhesion formation | International Journal of Molecular Sciences | 2020 | |
Wilson, Kitchener D. et al. | Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates | Developmental Cell | 2020 | |
Reyes-Miguel, Tania et al. | CDC42 drives RHOA activity and actin polymerization during capacitation | Reproduction | 2020 | |
Ursino, Gloria M et al. | ABCA12 regulates insulin secretion from β‐cells | EMBO reports | 2020 | |
Novak, Caymen M. et al. | Compressive stimulation enhances ovarian cancer proliferation, invasion, chemoresistance, and mechanotransduction via cdc42 in a 3d bioreactor | Cancers | 2020 | |
Wu, Huijuan et al. | Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells | Cell | 2020 | |
Zhang, Xiao et al. | Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration | JCI Insight | 2020 | |
Gorisse, Laetitia et al. | Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42 | Journal of Biological Chemistry | 2020 | |
Zanin, Juan P. et al. | The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors | Journal of Neuroscience | 2019 | |
Wu, Xuping et al. | Wnt5a induces ROR1 and ROR2 to activate RhoA in esophageal squamous cell carcinoma cells | Cancer Management and Research | 2019 | |
Santhana Kumar, Karthiga et al. | TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma | Cell Reports | 2018 | |
Yan, Ting et al. | Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells | Journal of Biological Chemistry | 2018 | |
Suraneni, Praveen K. et al. | Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity | Blood Advances | 2018 | |
Mayer, Louisa et al. | Nbeal2 interacts with Dock7, Sec16a, and Vac14 | Blood | 2018 | |
Veluthakal, Rajakrishnan et al. | Restoration of glucose-stimulated Cdc42-PAK1 activation and insulin secretion by a selective Epac activator in type 2 diabetic human islets | Diabetes | 2018 | |
Gu, Changkyu et al. | Dynamin autonomously regulates podocyte focal adhesion maturation | Journal of the American Society of Nephrology | 2017 | |
Ruggiero, Carmen et al. | Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion | Science Signaling | 2017 | |
Kim, Jongshin et al. | YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation | Journal of Clinical Investigation | 2017 | |
Xiao, Bin et al. | Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling | Oncotarget | 2016 | |
Jones, Eleanor L. et al. | Dendritic Cell Migration and Antigen Presentation Are Coordinated by the Opposing Functions of the Tetraspanins CD82 and CD37 | The Journal of Immunology | 2016 | |
Sroka, Jolanta et al. | Lamellipodia and membrane blebs drive efficient electrotactic migration of rat walker carcinosarcoma cells WC 256 | PLoS ONE | 2016 | |
Zhao, Chen Ze et al. | Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling | Scientific Reports | 2016 | |
Tien, Sui Chih et al. | The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42 | Nature Communications | 2016 | |
Martins, Rui et al. | Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions | Nature Immunology | 2016 | |
Herrera-Martínez, Mayra et al. | Antiamoebic activity of Adenophyllum aurantium (L.) strother and its effect on the actin cytoskeleton of Entamoeba histolytica | Frontiers in Pharmacology | 2016 | |
Ochoa-Alvarez, Jhon A. et al. | Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms | Oncotarget | 2015 | |
Guo, Yuna et al. | A novel pharmacologic activity of keto***** for therapeutic benefit in ovarian cancer patients | Clinical Cancer Research | 2015 | |
Breslin, Jerome W. et al. | Involvement of local lamellipodia in endothelial barrier function | PLoS ONE | 2015 | |
Yan, Yi et al. | Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5 | Nature Communications | 2015 | |
Hanin, Geula et al. | Competing targets of microRNA-608 affect anxiety and hypertension | Human Molecular Genetics | 2014 | |
Ahn, Bum Ju et al. | Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics | Journal of Biological Chemistry | 2014 | |
Rigano, Luciano A. et al. | Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread | Cellular Microbiology | 2014 | |
Chakravarti, Bandana et al. | Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents | Journal of Medicinal Chemistry | 2014 | |
Kalia, Manjula et al. | Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic Mechanism | Journal of Virology | 2013 | |
Yao, Honghong et al. | Nonmuscle myosin light-chain kinase mediates microglial migration induced by HIV Tat: involvement of β1 integrins | FASEB journal | 2013 | |
Dubash, Adi D. et al. | The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1 | Journal of Cell Biology | 2013 | |
Ramsay, Alan G. et al. | Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenali****** | Blood | 2013 | |
Bray, Kristi et al. | Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration | Breast Cancer Research | 2013 | |
Chen, Bin et al. | Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction | Cellular Physiology and Biochemistry | 2013 | |
Yang, Jian et al. | Cardiac-specific overexpression of farnesyl pyrophosphate synthase induces cardiac hypertrophy and dysfunction in mice | Cardiovascular Research | 2013 | |
Valtcheva, Nadejda et al. | The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42 | Journal of Biological Chemistry | 2013 | |
Barrio, Laura et al. | TLR4 Signaling Shapes B Cell Dynamics via MyD88-Dependent Pathways and Rac GTPases | The Journal of Immunology | 2013 | |
Chen, Guang et al. | Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2 | Journal of Biological Chemistry | 2012 | |
Dhaliwal, Anandika et al. | Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPases | PLoS ONE | 2012 | |
Eggers, Carrie M. et al. | STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells | The Journal of biological chemistry | 2012 | |
Ramsay, Alan G. et al. | Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancer | Blood | 2012 | |
Chen, Si Meng et al. | Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR | Biochemical Pharmacology | 2012 | |
Elali, Ayman et al. | Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells | Brain Pathology | 2012 | |
Martin-Granados, Cristina et al. | A role for PP1/NIPP1 in steering migration of human cancer cells | PLoS ONE | 2012 | |
Lichtenstein, Mathieu P. et al. | Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives | Journal of Alzheimer's disease : JAD | 2010 | |
McHenry, Peter R. et al. | P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis | Breast Cancer Research | 2010 | |
Romero, Ana M. et al. | Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture | Toxicological Sciences | 2010 | |
Stankiewicz, Traci E. et al. | GTPase activating protein function of p85 facilitates uptake and recycling of the β1 integrin | Biochemical and biophysical research communications | 2010 | |
Heckman-Stoddard, Brandy M. et al. | Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression | 2009 | ||
Schlegel, Nicolas et al. | Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium | Microcirculation (New York, N.Y. : 1994) | 2009 |
Author | Title | Journal | Year | Article Link |
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He, Yi et al. | CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis | Cell reports | 2023 | |
Phuyal, Santosh et al. | Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 | The EMBO Journal | 2022 | |
Nath, Anu S. et al. | Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses | Cell Reports | 2022 | |
Turgu, Busra et al. | HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner | Oncogene | 2021 | |
Garitano-Trojaola, Andoni et al. | Actin cytoskeleton deregulation confers midostaurin resistance in FLT3-mutant acute myeloid leukemia | Communications biology | 2021 | |
Zhu, Bili et al. | Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: An early event prior to insulin resistance | Theranostics | 2020 | |
Berthenet, Kevin et al. | Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness | Cell Reports | 2020 | |
Crawford, Melissa et al. | Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin | Journal of Investigative Dermatology | 2020 | |
Elshaer, Sally L. et al. | Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway | Diabetologia | 2019 | |
El-Naggar, Amal M. et al. | HACE1 is a potential tumor suppressor in osteosarcoma | Cell Death and Disease | 2019 | |
Yan, Ting et al. | Integrin αvβ3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells | Journal of Biological Chemistry | 2018 | |
Kang, Jeong Hun et al. | Protein kinase Cα as a therapeutic target in cancer | Protein Kinase C: Emerging Roles and Therapeutic Potential | 2018 | |
Kai, Masahiro et al. | Epigenetic silencing of diacylglycerol kinase gamma in colorectal cancer | Molecular Carcinogenesis | 2017 | |
Jeong, Suk Yeong et al. | Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling | Oncotarget | 2017 | |
Ruggiero, Carmen et al. | Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion | Science Signaling | 2017 | |
Kim, Jongshin et al. | YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation | Journal of Clinical Investigation | 2017 | |
Thuault, Sylvie et al. | The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity | Molecular Biology of the Cell | 2016 | |
Sylow, Lykke et al. | Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice | Journal of Physiology | 2016 | |
Sarowar, Tasnuva et al. | Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2 | Molecular Brain | 2016 | |
Marchesin, Valentina et al. | ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-Actin rosettes in breast cancer cells in response to epidermal growth factor | PLoS ONE | 2015 | |
Reyes-Reyes, E. Merit et al. | Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation | Molecular Oncology | 2015 | |
Yan, Yi et al. | Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5 | Nature Communications | 2015 | |
Sylow, Lykke et al. | Rac1 - a novel regulator of contraction-stimulated glucose uptake in skeletal muscle | Experimental Physiology | 2014 | |
Radeva, Mariya Y. et al. | PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation | PLoS ONE | 2014 | |
Nakajima, Chikako et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development | Development (Cambridge) | 2014 | |
Kikuchi, K. et al. | Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma | Oncogene | 2013 | |
Bray, Kristi et al. | Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration | Breast Cancer Research | 2013 | |
Sylow, Lykke et al. | Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle | Diabetes | 2013 | |
Redhu, Naresh Singh et al. | Thymic stromal lymphopoietin induces migration in human airway smooth muscle cells | Scientific Reports | 2013 | |
Eggers, Carrie M. et al. | STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells | The Journal of biological chemistry | 2012 | |
Sayedyahossein, Samar et al. | Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytes | FASEB Journal | 2012 | |
Vives, Virginie et al. | The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts | 2011 | ||
Binker, Marcelo G. et al. | TGF-β1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-κB/IL-6/MMP-2 | Biochemical and biophysical research communications | 2011 | |
Kigel, Boaz et al. | Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling | Blood | 2011 | |
McHenry, Peter R. et al. | P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis | Breast Cancer Research | 2010 | |
Johanna, Gutiérrez Vargas et al. | Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemia | Neurochemistry international | 2010 | |
Kamai, Takao et al. | Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer | BMC Cancer | 2010 | |
Baumer, Y. et al. | Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown | Journal of Cellular Physiology | 2009 | |
Heckman-Stoddard, Brandy M. et al. | Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression | 2009 | ||
Chastre, Eric et al. | TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness | The FASEB Journal | 2009 | |
Moniz, Sónia et al. | WNK2 modulates MEK1 activity through the Rho GTPase pathway | Cellular signalling | 2008 | |
Ramirez, Servio H. et al. | Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes | The Journal of Immunology | 2008 | |
Petroll, W. Matthew et al. | Dynamic assessment of fibroblast mechanical activity during rac-induced cell spreading in 3-D culture | Journal of Cellular Physiology | 2008 | |
Pontow, Suzanne et al. | Antiviral Activity of a Rac GEF inhibitor Characterized with a Sensitive HIV/SIV Fusion Assay | Virology | 2007 |
Author | Title | Journal | Year | Article Link |
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Morstein, Johannes et al. | Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. | Cell | 2024 | |
Tanaka, Masato et al. | Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases | Communications Biology | 2024 | |
Wu, Yi et al. | Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia | Journal of Cellular and Molecular Medicine | 2024 | |
Szigeti, Kinga et al. | CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization | eBioMedicine | 2024 | |
Raykhel, I. et al. | HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia | Scientific Reports | 2024 | |
Liu, Xiaomin et al. | RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulation | Journal of Virology | 2024 | |
Koenis, Duco Steven et al. | Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis | Advanced Science | 2024 | |
Mendoza-Soto, Pablo et al. | Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes | Cells | 2024 | |
Vahldieck, Carl et al. | Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axis | Frontiers in Immunology | 2024 | |
Wu, Fei et al. | Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight | Nature Communications | 2024 | |
Lee, Choong Jae et al. | The dysadherin/FAK axis promotes individual cell migration in colon cancer | International Journal of Biological Sciences | 2024 | |
Laragione, Teresina et al. | KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypes | Frontiers in Immunology | 2024 | |
Moztarzadeh, Sina et al. | Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activation | Scientific Reports | 2024 | |
Hong, Geunhye et al. | Campylobacter jejuni Modulates Reactive Oxygen Species Production and NADPH Oxidase 1 Expression in Human Intestinal Epithelial Cells | Cellular Microbiology | 2023 | |
Adhicary, Subhodip et al. | Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous Malformation | Stroke | 2023 | |
Szigeti, Kinga et al. | Neuronal actin cytoskeleton gain of function in the human brain | eBioMedicine | 2023 | |
Xie, Wangkai et al. | ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancer | Cell Death & Disease | 2023 | |
Takaya, Kento et al. | Compound 13 Promotes Epidermal Healing in Mouse Fetuses via Activation of AMPK | Biomedicines | 2023 | |
Wang, Yanan et al. | PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex | Nature Communications | 2023 | |
Toffali, Lara et al. | An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking | Cell reports | 2023 | |
Turgu, Busra et al. | The HACE1 E3 ligase mediates RAC1 ‐dependent control of mTOR signaling complexes | EMBO reports | 2023 | |
Bartos, Katalin et al. | Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity | Journal of Cell Communication and Signaling | 2023 | |
St. Paul, Amanda et al. | FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms | Cell reports | 2023 | |
Castillo-Azofeifa, David et al. | A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling | Cell stem cell | 2023 | |
Dang, Iren et al. | Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3 | Journal of Cell Science | 2023 | |
Tokarz, Victoria L. et al. | Palmitate-induced insulin resistance causes actin filament stiffness and GLUT4 mis-sorting without altered Akt signalling | Journal of Cell Science | 2023 | |
Carbonell, Abigail U. et al. | Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling | Frontiers in Aging Neuroscience | 2023 | |
Crespo, Grace Velez et al. | The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer | Molecular Medicine | 2023 | |
Darp, Revati et al. | Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis | Nature Communications | 2022 | |
Harms, Julia et al. | Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion | Cancer Gene Therapy | 2022 | |
Francis, Caitlin R. et al. | Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis | Nature Communications | 2022 | |
Kim, Seunghoon et al. | Investigating the Anti-Inflammatory Effects of RCI001 for Treating Ocular Surface Diseases: Insight Into the Mechanism of Action | Frontiers in Immunology | 2022 | |
Sugisawa, Erika et al. | Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia | Cell Reports | 2022 | |
Ma, Yuanyuan et al. | Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development | Development (Cambridge) | 2021 | |
Gurusamy, Malarvizhi et al. | G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators | Nature Communications | 2021 | |
Kinsella, Sinéad et al. | Attenuation of apoptotic cell detection triggers thymic regeneration after damage | Cell Reports | 2021 | |
Mao, De Yu et al. | CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function | Science Signaling | 2021 | |
Wegscheid, Michelle L. et al. | Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis | Cell Reports | 2021 | |
Vallejo, Daniela et al. | Wnt5a modulates dendritic spine dynamics through the regulation of Cofilin via small Rho GTPase activity in hippocampal neurons | Journal of Neurochemistry | 2021 | |
Krueger, Irena et al. | Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPases | Arteriosclerosis, Thrombosis, and Vascular Biology | 2020 | |
Rong, Zhouyi et al. | Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models | FASEB Journal | 2020 | |
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Falace, Antonio et al. | FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex | Neurobiology of Disease | 2024 | |
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Serwe, Guillaume et al. | CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling | Nature Communications | 2023 | |
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Wang, Xiaobo et al. | Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis | Cell Metabolism | 2020 | |
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Jiao, Yi et al. | Mechanism of H2S‑mediated ROCK inhibition of total flavones of Rhododendra against myocardial ischemia injury | Experimental and Therapeutic Medicine | 2019 | |
Ma, Teng jiao et al. | CLOCK and BMAL1 stabilize and activate RHOA to promote F-actin formation in cancer cells | Experimental and Molecular Medicine | 2018 | |
Zhang, Xin et al. | Fasudil increases temoz******* sensitivity and suppresses temoz*******-resistant glioma growth via inhibiting ROCK2/ABCG2 | Cell Death and Disease | 2018 | |
Lehman, Heather L. et al. | NFkB hyperactivation causes invasion of esophageal squamous cell carcinoma with EGFR overexpression and p120-catenin down-regulation | Oncotarget | 2018 | |
Goodman, Linda et al. | Integrin α8 and Pcdh15 act as a complex to regulate cilia biogenesis in sensory cells | Journal of Cell Science | 2017 | |
Islam, Salman Ul et al. | PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition | Oncotarget | 2017 | |
Cho, Soo Young et al. | Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers | Gastroenterology | 2017 | |
Watts, Bruns A. et al. | High-mobility group box 1 inhibits HCO3_ absorption in the medullary thick ascending limb through RAGE-rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange | American Journal of Physiology - Renal Physiology | 2016 | |
Gilbert, James et al. | The X-linked autism protein KIAA2022/KIDLIA regulates neurite outgrowth via N-cadherin and δ-catenin signaling | eNeuro | 2016 | |
Wang, Y. et al. | Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864 | British Journal of Pharmacology | 2015 | |
Su, Chien Chia et al. | Phenotypes of trypsin- and collagenase-prepared bovine corneal endothelial cells in the presence of a selective rho kinase inhibitor, Y-27632 | Molecular Vision | 2015 | |
Wang, Shi Jie et al. | CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells | Oncotarget | 2015 | |
Yan, Chao et al. | Discovery and characterization of small molecules that target the GTPase Ral | Nature | 2014 | |
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Zhan, Hong et al. | The effect of an NgR1 antagonist on the neuroprotection of cortical axons after cortical infarction in rats | Neurochemical Research | 2013 | |
Xie, Xi et al. | Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy | Molecular and cellular endocrinology | 2013 | |
Hara, Yusuke et al. | Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus notochord formation during gastrulation | Developmental Biology | 2013 | |
Nithipatikom, Kasem et al. | Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells | Endocrinology | 2012 | |
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Li, B. et al. | RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells | Oncogene | 2012 | |
Cheng, Haoran et al. | Infrasonic noise induces axonal degeneration of cultured neurons via a Ca²⁺ influx pathway | Toxicology letters | 2012 | |
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Ríos, Amelia et al. | Participation of Rho, ROCK-2, and GAP activities during actin microfilament rearrangements in Entamoeba histolytica induced by fibronectin signaling | Cell Biology International | 2008 | |
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Pixley, Fiona J. et al. | BCL6 suppresses RhoA activity to alter macrophage morphology and motility | Journal of cell science | 2005 | |
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Yang, Seun Ah et al. | Rho and Rho-kinase mediate thrombin-induced phosphatidylinositol 4-phosphate 5-kinase trafficking in platelets | Journal of Biological Chemistry | 2004 | |
Orr, Anthony Wayne et al. | Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion Disassembly | Journal of Biological Chemistry | 2004 | |
Cetin, Selma et al. | Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions | The Journal of biological chemistry | 2004 | |
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Peng, Yundong et al. | RhoA-mediated G12-G13 signaling maintains muscle stem cell quiescence and prevents stem cell loss | Cell Discovery | 2024 | |
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Morel, Anne et al. | Bone resorption by osteoclasts involves fine tuning of RHOA activity by its microtubule-associated exchange factor GEF-H1 | Frontiers in Physiology | 2024 | |
Ren, Xiaoyu et al. | Loss of Myo19 increases metastasis by enhancing microenvironmental ROS gradient and chemotaxis | EMBO Reports | 2024 | |
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Wong, Darren Chen Pei et al. | Hiltonol, a dsRNA Mimic, Promotes NK Cell Anticancer Cytotoxicity Through TAZ Cytoplasmic Sequestration | Advanced Therapeutics | 2023 | |
Zhang, Xingyu et al. | Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease | Nature Communications | 2023 | |
Morishita, Jun et al. | Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells | Open Biology | 2023 | |
Leguay, Kévin et al. | Interphase microtubule disassembly is a signaling cue that drives cell rounding at mitotic entry | Journal of Cell Biology | 2022 | |
Khan, Alamzeb et al. | ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak | FASEB journal | 2022 | |
You, Jae Sung et al. | ARHGEF3 Regulates Skeletal Muscle Regeneration and Strength through Autophagy | Cell Reports | 2021 | |
Afanasyeva, Elena A. et al. | Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma | Life Science Alliance | 2021 | |
Evans, Frances et al. | Signaling pathways in cytoskeletal responses to plasma membrane depolarization in corneal endothelial cells | Journal of Cellular Physiology | 2020 | |
Addis, Dylan R. et al. | Vascular permeability disruption explored in the proteomes of mouse lungs and human microvascular cells following acute bromine exposure | American Journal of Physiology - Lung Cellular and Molecular Physiology | 2020 | |
Liang, Xiaoting et al. | Acetylation dependent functions of Rab22a-NeoF1 Fusion Protein in Osteosarcoma | Theranostics | 2020 | |
Huang, Yuxing et al. | Arp2/3-branched actin maintains an active pool of GTP-RhoA and controls RhoA abundance | Cells | 2019 | |
Choi, Michael Y. et al. | Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia | Cell Stem Cell | 2018 | |
Yu, Lixia et al. | C-Maf inducing protein inhibits coflin-1 activity and alters podocyte cytoskeleton organization | Molecular Medicine Reports | 2017 | |
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Li, Shufeng et al. | Microtopographical features generated by photopolymerization recruit RhoA/ROCK through TRPV1 to direct cell and neurite growth | Biomaterials | 2015 | |
Sabbatini, Maria Eugenia et al. | Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling | PLoS ONE | 2013 | |
Gray, Jason D. et al. | LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure | Human Molecular Genetics | 2013 | |
Xu, Jie et al. | RhoGAPs Attenuate Cell Proliferation by Direct Interaction with p53 Tetramerization Domain | Cell Reports | 2013 | |
Buranda, Tione et al. | Rapid parallel flow cytometry assays of active GTPases using effector beads | Analytical Biochemistry | 2013 | |
Zhang, Y. et al. | High glucose-induced RhoA activation requires caveolae and PKCβ1-mediated ROS generation | American journal of physiology. Renal physiology | 2012 | |
Kyrkou, A. et al. | RhoD participates in the regulation of cell-cycle progression and centrosome duplication | Oncogene 2013 32:14 | 2012 | |
Cartier-Michaud, Amandine et al. | Matrix-bound PAI-1 supports cell blebbing via RhoA/rock1 signaling | PLoS ONE | 2012 | |
Ponsaerts, Raf et al. | RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system | PLoS ONE | 2012 | |
Ladhani, Omar et al. | Pigment Epithelium-Derived Factor Blocks Tumor Extravasation by Suppressing Amoeboid Morphology and Mesenchymal Proteolysis | Neoplasia (New York, N.Y.) | 2011 | |
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Wang, Shizhen Emily et al. | Transforming Growth Factor β (TGF-β)-Smad Target Gene Protein Tyrosine Phosphatase Receptor Type Kappa Is Required for TGF-β Function | Molecular and Cellular Biology | 2005 | |
Ishii, Satoshi et al. | Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor | The Journal of biological chemistry | 2005 | |
Bi, Yan et al. | A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini | American journal of physiology. Cell physiology | 2005 | |
Wang, Qin et al. | Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells | The Journal of biological chemistry | 2004 | |
Saito, Shin'ichi et al. | Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation | The Journal of biological chemistry | 2004 | |
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