Actin Cytoskeleton and Neuronal Aging

Introduction

Actin is the most abundant protein in most eukaryotic cells. The actin cytoskeleton is essential for diverse biological processes, including cell division, muscle contraction, cellular signaling, and motility. The dynamic assembly and disassembly of actin filaments from monomeric (G-actin) to filamentous (F-actin) is key to these processes. Dysfunction in actin dynamics is observed with age and is characteristic of various disease processes.  Over the last several years, evidence has identified multiple roles for actin dynamics in neuronal aging and age-related neurodegenerative diseases such as Alzheimer’s. This newsletter highlights recent publications that have advanced our understanding of actin dynamics in neuronal aging.

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Also included in this newsletter:

• Actin and Signal Seeker Tools
• Related Publications