Actin: a critical player in cancer cell immunosurveillance

Actin is a globular protein that can assemble into filamentous structures and is a foundational member of the cytoskeleton network in cells.  Actin has well-established roles in muscle contraction, vesicle movement, cell motility, and many other biological processes.  Emerging studies have highlighted its essential role in regulation of the immune system, whereby, mutations in actin and actin binding proteins (ABPs) lead to an array of inflammatory and/or immunodeficiency disorders...

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