Cytoskeleton Inc. - Small G-Protein News

Rho GTPases and Kidney Disease

• Feb 6, 2024

An Isoform of the Giant Protein Titin is a Master Regulator of Human T Lymphocyte Trafficking

• Jan 26, 2024

Stick It To RAS: The Next Wave Of RAS Therapeutics

• Dec 12, 2023

Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

• Nov 14, 2023

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

• Aug 15, 2023

RhoA/ROCK in Metabolic Syndrome

• Jun 8, 2023

Manipulation of Small GTPases by Pathogenic Bacteria

• Apr 3, 2023

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

• Jan 26, 2023

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodeling in neural crest cells

• Oct 10, 2022

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite

• Sep 12, 2022

September 2022 Newsletter: RhoA/ROCK Signaling in Cardiac Pathophysiology

• Sep 2, 2022

Oncogenic RAS signaling and Tumor Immune Evasion: Mechanisms and Therapeutic Opportunity

• Apr 4, 2022

Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

• Mar 22, 2022

The Cytoskeleton’s Role In Autism Spectrum Disorder

• Feb 8, 2022

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

• Dec 7, 2021

Rac1 And Cdc42 Pathways As Pivotal Axis In Future Metastatic Cancer Therapy

• Nov 2, 2021

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis

• Oct 12, 2021

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

• Sep 21, 2021

KRAS No Longer Undruggable

• Jun 8, 2021

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

• Mar 23, 2021

Small G-Proteins And Microvesicle-Mediated Cancer Biogenesis

• Mar 16, 2021

RHOA-mediated mechanical force generation through Dectin-1

• Jan 26, 2021

A highlight of Cytoskeleton's Activation Assays and their utility in several studies

• Jan 12, 2021

Virus infection induces RhoA Activation

• Apr 7, 2020

Citation Spotlight:RhoA activation by SUN1/2 of the LINC complex controls actomyosin-dependent force generation and morphological changes in vascular smooth muscle cells

• Mar 12, 2020

Citation Spotlight: RhoA and NLRP3 inflammasome activation in in vivo and in vitro models of sepsis-induced intestinal dysfunction

• Feb 6, 2020

January 2020 Newsletter : Rho GTPases Control Cell Migration

• Jan 10, 2020

Citation Spotlight: Wnt5a regulation of RhoA-mediated remodeling of actin cytoskeleton to control ESCC cell motility

• Jan 6, 2020

Citation Spotlight: Arp2/3 regulates RhoA activity and protein levels through cortactin/p190RhoGAP and CCM2/Smurf1, respectively

• Jan 2, 2020

Citation Spotlight: RCC2 Mediates Apoptosis Through Inhibition of GEF-Mediated Rac1 Activation

• Dec 31, 2019

Citation Spotlight: RhoA Mediates Inhibition of Neurite Outgrowth by Amyloid Precursor Protein Homodimers

• Dec 31, 2019

October 2019 Newsletter: RhoB GTPase Tumor Supporter or Suppressor?

• Sep 30, 2019

Citation Spotlight: RhoA-mediated morphological and functional plasticity in nucleus accumbens neurons

• Aug 19, 2019

August 2019 Newsletter Rac1B, Cancer, and Rac1

• Aug 6, 2019

July Newsletter: Rho-family GTPases, Neuronal Plasticity, and Depression

• Jul 19, 2019

Citation Spotlight: Tctex-1, Novel Binding Partner of KIM-1, and Phagocytosis of Apoptotic Cells

• Nov 12, 2018

Citation Spotlight: RhoA Activation and F-actin Stress Fiber Formation Underlies FAM13A-Mediated Changes in Cystic Fibrosis Lung Phenotype

• Oct 9, 2018

August Newsletter: Rab GTPases and Neurodegeneration

• Aug 6, 2018

Citation Spotlight: RhoA Activation and Vascular Inflammation

• Jul 23, 2018

June Newsletter: Why Does K-Ras Display Oncogenic Specificity?

• Jun 5, 2018

April Newsletter: Rho Family GEFs and Dendritic Spine Structural Plasticity

• Apr 3, 2018

January Newsletter: The GEF Trio and Its Role in Autism Spectrum Disorders

• Jan 16, 2018

Citation Spotlight: Vav2 GEF Binds Phosphorylated Cortactin for Activation of Rac3 in Invadopodia

• Nov 21, 2017

Citation Spotlight: RhoA Activity Regulated by Src-Mediated Phosphorylation of ARHGAP42

• Sep 21, 2017

Citation Spotlight: ARNO-Arf1 Pathway Regulates RhoA Activity to Control Podosome Formation

• Jul 17, 2017

May Newsletter: Arf6 GEFs and Cancer Cell Invasion and Metastasis

• May 16, 2017

Citation Spotlight: Selective G12D K-Ras Inhibitors Discovered via Phage Display Technology

• Mar 16, 2017

Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis

• Jan 23, 2017

Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway

• Dec 21, 2016

Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders

• Dec 5, 2016

November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling

• Nov 16, 2016

Citation Spotlight: Rho GTPases and epidermal stem cell migration

• Sep 29, 2016

Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis

• Sep 15, 2016

Citation Highlight: Rac1: Essential for fibroblast-like synoviocyte migration, invasion, and activation

• Jun 16, 2016

April Newsletter: Rac1 in Diabetes: The Good and Bad

• Apr 18, 2016

PI3K/Akt/Rac1 activated by MMP-8 and TGF-ß1 interplay in hepatocellular carcinoma

• Apr 13, 2016

Rho-family GTPases: Regulation by Opposing Tetraspanins in Dendritic Cells

• Feb 9, 2016

RhoA and Cdc42 Activity Mediates Podoplanin-induced Tumor Progression

• Feb 2, 2016

Rac1 Regulation ASCB 2015 Abstract

• Jan 18, 2016

Rac1 Activity and SOD1 Aggregates

• Dec 8, 2015

Dr. Alan Hall - GTPase Legacy

• Sep 25, 2015

Ras Cancer Therapeutics: 5 Promising Targets

• May 1, 2015

YAP1 grabs the spotlight in oncogenic Ras addiction

• Mar 26, 2015

Post-translational Modifications Regulate Ral GTPases

• Mar 9, 2015

Phosphorylation of RhoA as a Regulator of Signal Transduction

• Jan 26, 2015

GTPase Activation Assays: Detecting Different Isoforms

• Jan 19, 2015

New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

• Jul 1, 2014

Rho GTPases and Reactive Oxygen Species: Crosstalk and Feedback

• Jun 27, 2014

Ras and Rho Post-translational Modification by Prenylation

• Sep 18, 2013

New Arf1 and Arf6 Activation Assays

• Jan 31, 2013

Dendritic Spines: Role of Arf6 in Development

• Jan 4, 2013

The Role of Rac1 GTPase in Neurodegeneration

• Sep 4, 2012

Epithelial-Mesenchymal Transition (EMT) and the Involvement of Rho Family Small G-proteins

• Jul 31, 2012

Trafficking: Arfs and the Cdc42/Rac connection

• Mar 31, 2012

Cardiac Research Using G-LISA Technology

• Feb 27, 2012

New Small G-protein Tools

• Oct 12, 2011

Small G-protein Activation Assay News

• Oct 12, 2011