Invasion by actin-driven membrane protrusions: Cortactin in focus

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Cortactin’s multiple signaling domains

The actin binding protein cortactin plays an important role in several cellular functions involving plasma membrane changes that are dependent on a dendritic (i.e., branched) actin network: cell motility employing lamellipodia, clathrin dependent and independent endocytosis, host-pathogen interactions, maintenance of endothelial barrier integrity, and invadopodia-mediated cell invasion1.  Cortactin is a monomeric ~80 kDa protein that derives its name from its intracellular colocalization with cortical actin at the periphery of the cell2.  The amino terminus of cortactin harbors a... Click to read more


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Posted in News By

daren young