Invasion by actin-driven membrane protrusions: Cortactin in focus


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Cortactin’s multiple signaling domains

The actin binding protein cortactin plays an important role in several cellular functions involving plasma membrane changes that are dependent on a dendritic (i.e., branched) actin network: cell motility employing lamellipodia, clathrin dependent and independent endocytosis, host-pathogen interactions, maintenance of endothelial barrier integrity, and invadopodia-mediated cell invasion1.  Cortactin is a monomeric ~80 kDa protein that derives its name from its intracellular colocalization with cortical actin at the periphery of the cell2.  The amino terminus of cortactin harbors a... Click to read more

 

Also included in this newsletter:

 

  • Actin Related Publications

 

  • Actin Protein Research Tools

 

Posted in News By

daren young