Malaria influences the cytoskeleton during it’s lifecycle

Malaria has an annual death toll exceeding 400,000 lives and an estimated 229 million cases as recorded worldwide in 2019⁽¹⁾. Africa is the hardest-hit region, as it accounts for >90% of all malaria cases and deaths⁽²⁾. Children under the age of 5 years are the most vulnerable group to malaria, where approximately 1200 African children die each day^(3,4). The transmission of malaria is caused by the protozoal Plasmodium parasite through the bites of female mosquitoes from the Anopheles genus⁽⁵⁾. P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi are the five Plasmodium spp. that cause malaria in humans. P. falciparum is the predominant parasitic species that accounts for nearly all the malaria cases in sub-Saharan Africa, while P. vivax is the leading cause of malaria in South America and Southeast Asia⁽⁶⁾.

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