There are over 670 post translational modification (PTM) types currently described (1) and it has been estimated that up to 21% of disease associated single nucleotide missense mutations are located in protein PTM sites (2). Besides theflagship PTM target of the phosphorylation pathway (currently 65 FDA approved kinase inhibitor drugs ), drugs targeting the acetylation, PARylation and ubiquitination PTM pathways have received FDA approval (4-5, Table 1). This newsletter briefly reviews some of the therapeutic advances in targeting the ubiquitination PTM pathway and highlights the clinical importance and potential of PTMs in drug discovery.
- Ubiquitnation Tools and Kits
- Related Publications