Compound Screening
Cytoskeleton, Inc. is a reliable source of compound screening services for developing tubulin inhibitors, microtubule inhibitors, myosin inhibitors and the sarcomere inhibitors, kinesin inhibitors and small G-protein inhibitors. Over the past 20 years numerous companies have contracted with us to provide early discovery data, regular data for SAR based compound optimization and pre-clinical drug development analysis and validation. In all cases the client was provided with regular updates as their project progressed, and timely completion and full project details were recorded in a comprehensive report. Our experts can provide in depth knowledge and advice in the cytoskeleton and signal transduction areas, which is suitable for SAR based research and primary and secondary screening. Target proteins have rapidly available assays include the GEFs (Dbs, LARG, Ras-GRF, SOS1, Tiam1, Vav1, Vav2), kinesins (Eg5, KIF5, KIF1C, KIFC1, KIF, KIF3C, KIFC3, MKLP1, MKLP2, MCAK, CenPE, Chromokinesin), myosins (myosin S1, heavy merosmyosin, calcium sensitive soluble sarcomeric atpase), small g-proteins (N-Ras, H-Ras, K-Ras, R-Ras, RhoA, RhoB, RhoC, Rac1, Rac2, Rac3, Cdc42, Arf1, Arf6), and the tubulin targets like neuronal tubulin, microtubules and species specific FtsZ proteins, as well as specialized tubulins such as cancer cell line or tumor tubulin, plant tubulin, and fungal tubulin.
We have introduced a modular format to the assays which allow easier recognition of the suitability of each format for your project's purposes. The readily available modules are summarized below. More details are available by click on the About tab above.
Click on a link below to see the full range of assays:
FtsZ GTPase and Polymerization Assays
GTP Exchange Factor (GEF) Exchange Assays
GTPase Activating Protein Assays
If you have an immediate question please select from the buttons above or send an e-mail describing your requirements to tservice@cytoskeleton.com.
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Screen name | Amount | Module Code |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 32 assays (1 IC50 + 1 Control IC50) | CDS001 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 32 assays (14 duplicates + 2 Controls + 2 blanks) | CDS002 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 96 assays (5 IC50 + 1 Control IC50) | CDS003 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS004 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 192 assays (10 IC50 + 2 Control IC50) | CDS005 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 192 assays (80 duplicates + 8 Controls + 8 blanks) | CDS006 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 384 assays (20 IC50 + 4 Control IC50) | CDS007 |
Tubulin polymerization (colorimetric, 340nm) Neuronal tubulin, porcine brain | 384 assays (160 duplicates + 16 Controls + 16 blanks) | CDS008 |
Tubulin polymerization (fluorescence, 360nm/410nm) Neuronal tubulin, porcine brain | 96 assays (5 IC50 + 1 Control IC50) | CDS009 |
Tubulin polymerization (fluorescence,. 360nm/410nm) Neuronal tubulin, porcine brain | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS010 |
Tubulin polymerization (fluorescence, 360nm/410nm) Neuronal tubulin, porcine brain | 192 assays (10 IC50 + 2 Control IC50 | CDS011 |
Tubulin polymerization (fluorescence, 360nm/410nm) Neuronal tubulin, porcine brain | 192 assays (80 duplicates + 8 Controls + 8 blanks) | CDS012 |
Tubulin polymerization (fluorescence, 360nm/410nm) Neuronal tubulin, porcine brain | 384 assays (20 IC50 + 4 Control IC50 | CDS013 |
Tubulin polymerization (fluorescence,. 360nm/410nm) Neuronal tubulin, porcine brain | 384 assays (160 duplicates + 16 Controls + 16 blanks) | CDS014 |
Tubulin polymerization (fluorescence, 360nm/410nm) MCF-7 cancer cell tubulin | 60 assays (5 IC50 + 1 Control IC50) | CDS015 |
Tubulin polymerization (fluorescence, 360nm/410nm) MCF-7 cancer cell tubulin | 60 assays (28 duplicates + 4 Controls) | CDS016 |
Tubulin polymerization (fluorescence, 360nm/410nm) MCF-7 cancer cell tubulin | 60 assays (5 IC50 + 1 Control IC50) | CDS017 |
Tubulin polymerization (fluorescence, 360nm/410nm) HeLa cancer cell tubulin | 60 assays (28 duplicates + 4 Controls) | CDS018 |
Tubulin polymerization (fluorescence, 360nm/410nm) HeLa cancer cell tubulin | 60 assays (5 IC50 + 1 Control IC50) | CDS019 |
Tubulin polymerization (fluorescence, 360nm/410nm) Other specialized tubulin (e.g. Caki cancer cell, soybean, maize, fungal) | 60 assays (28 duplicates + 4 Controls) | CDS020 |
Kinesin Motor assays (650nm) | 96-endpoint (5 IC50 + 1 Control IC50) | CDS050 |
Kinesin Motor assays (650nm) | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | CDS051 |
Kinesin Motor assays (360nm) | 96-kinetic (5 IC50 + 1 Control IC50) | CDS052 |
Kinesin Motor assays (360nm) | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | CDS053 |
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Myosin Motor assays (650nm) | 96-endpoint (5 IC50 + 1 Control IC50) | CDS054 |
Myosin Motor assays (650nm) | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | CDS055 |
Myosin Motor assays (360nm) | 96-kinetic (5 IC50 + 1 Control IC50) | CDS056 |
Myosin Motor assays (360nm) | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | CDS057 |
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Sarcomere assay (650nm), contains myosin S1 fragment (motor domain) with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-endpoint (5 IC50 + 1 Control IC50) | CDS058 |
Sarcomere assay (650nm), contains myosin S1 fragment (motor domain) with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | CDS059 |
Sarcomere assay (360nm), contains myosin S1 fragment (motor domain) with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-kinetic (5 IC50 + 1 Control IC50) | CDS060 |
Sarcomere assay (360nm), contains myosin S1 fragment (motor domain) with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | CDS061 |
| Dynein Motor assay | 96 endpoint assays, (5 IC50 + 1 Control IC50) | CDS062 |
| Dynein Motor assay | 96 endpoint assays, 40 duplicates + 4 Controls + 4 blanks | CDS063 |
Actin (skeletal muscle) polymerization | 96 assays (5 IC50s + 1 control) | CDS080 |
Actin (skeletal muscle) polymerization | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS081 |
Actin (non-muscle) polymerization | 96 assays (5 IC50s + 1 control) | CDS082 |
Actin (non-muscle) polymerization | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS083 |
FtsZ GTPase assay (650nm, endpoint) | 96 assays (5 IC50s + 1 control) | CDS250 |
| FtsZ GTPase assay (650nm, endpoint) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS251 |
| FtsZ GTPase assay (360nm, kinetic) | 96 assays (5 IC50s + 1 control) | CDS252 |
| FtsZ GTPase assay (360nm, kinetic) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS253 |
F-Actin Binding Spin-down Assays (skeletal muscle actin) | 24 assays (10 duplicates, four controls. | CDS090 |
F-Actin Binding Spin-down Assays (non muscle actin) | 24 assays (10 duplicates, four controls. | CDS091 |
GEF Assays | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS100 |
GAP Assays | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS105 |
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Tubulin ELISA (alpha) (total tubulin) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS200 |
Tubulin ELISA (beta I, II, III, IV, V or VI) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS201 |
Tubulin ELISA (acetylated alpha) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS202 |
Tubulin ELISA (glutamylated) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS203 |
Tubulin ELISA (glycinated) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS204 |
Tubulin ELISA (tyrosinated) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS205 |
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GLISA with extracts provided by Customer | 48 assays (20 duplicates + 4 Controls + 4 blanks) | CDS220 |
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GLISA with extracts made at Cytoskeleton | 48 assays (20 duplicates + 4 Controls + 4 blanks) | CDS221 |
RhoA ELISA (total RhoA) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | CDS222 |
Screening Modules available at short notice
Screen name | Target protein | Amount | Deliverables | Timeline (weeks) | Module Code |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 32 assays (1 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS001 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 32 assays (14 duplicates + 2 Controls + 2 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS002 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 96 assays (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS003 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS004 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 192 assays (10 IC50 + 2 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS005 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 192 assays (80 duplicates + 8 Controls + 8 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS006 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 384 assays (20 IC50 + 4 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS007 |
Tubulin polymerization (col. 340nm) | Pure porcine (T240) or bovine (TL238) brain tubulin. | 384 assays (160 duplicates + 16 Controls + 16 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS008 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 96 assays (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS009 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS010 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 192 assays (10 IC50 + 2 Control IC50 | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS011 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 192 assays (80 duplicates + 8 Controls + 8 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS012 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 384 assays (20 IC50 + 4 Control IC50 | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS013 |
Tubulin polymerization (flr. 360nm/410nm) | Pure porcine (T240) or bovine (TL238) brain tubulin.
| 384 assays (160 duplicates + 16 Controls + 16 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS014 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells. | 60 assays (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS015 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells. | 60 assays (28 duplicates + 4 Controls) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS016 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells. | 60 assays (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS017 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells. | 60 assays (28 duplicates + 4 Controls) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS018 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells. | 60 assays (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS019 |
Tubulin polymerization (flr. 360nm/410nm) | Pure tubulin isolated from Caki-1 tumor, HeLa cells, MCF-7 cells, insect cells, Soybean germlings or fungal cells.
| 60 assays (28 duplicates + 4 Controls) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 4 | CDS020 |
Kinesin Motor assays (650nm) | Any of the available kinesin motors in the CytoWerks Product Line, or MKLP2, KIF7, KIF1C or KIF1B motor domains in a reation with porcine brain microtubules. | 96-endpoint (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS050 |
Kinesin Motor assays (650nm) | Any of the available kinesin motors in the CytoWerks Product Line, or MKLP2, KIF7, KIF1C or KIF1B motor domains in a reation with porcine brain microtubules. | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS051 |
Kinesin Motor assays (360nm) | Any of the available kinesin motors in the CytoWerks Product Line, or MKLP2, KIF7, KIF1C or KIF1B motor domains in a reation with porcine brain microtubules. | 96-kinetic (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS052 |
Kinesin Motor assays (360nm) | Any of the available kinesin motors in the CytoWerks Product Line, or MKLP2, KIF7, KIF1C, or KIF1B motor domains in a reation with porcine brain microtubules. | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS053 |
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Myosin Motor assays (650nm) | Myosin II from rabbit skeletal muscle or bovine heart, S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard), skeletal muscle (rabbit) or non-muscle (bovine spleen), in a reaction with actin filaments. | 96-endpoint (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS054 |
Myosin Motor assays (650nm) | Myosin II from rabbit skeletal muscle or bovine heart, S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard), skeletal muscle (rabbit) or non-muscle (bovine spleen), in a reaction with actin filaments. | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS055 |
Myosin Motor assays (360nm) | Myosin II from rabbit skeletal muscle or bovine heart, S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard), skeletal muscle (rabbit) or non-muscle (bovine spleen), in a reaction with actin filaments. | 96-kinetic (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS056 |
Myosin Motor assays (360nm) | Myosin II from rabbit skeletal muscle or bovine heart, S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard), skeletal muscle (rabbit) or non-muscle (bovine spleen), in a reaction with actin filaments. | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS057 |
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Sarcomere assay (360nm) | Myosin S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard) or skeletal muscle (rabbit) in a reaction with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-endpoint (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS058 |
Sarcomere assay (360nm) | Myosin S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard) or skeletal muscle (rabbit) in a reaction with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS059 |
Sarcomere assay (360nm) | Myosin S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard) or skeletal muscle (rabbit) in a reaction with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-kinetic (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS060 |
Sarcomere assay (360nm) | Myosin S1 fragment (motor domain) from bovine heart, smooth muscle (chicken gizzard) or skeletal muscle (rabbit) in a reaction with tropomyosin / troponin(T/C/I) complex and actin filaments. | 96-kinetic (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS061 |
| Dynein Motor assay (650nm) | Cytoplasmic dynein isolated from porcine brain in a reaction with ATP and microtubules. Ciliobrevin-D as control. | 96-endpoint (5 IC50 + 1 Control IC50) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS062 |
| Dynein Motor assay (650nm) | Cytoplasmic dynein isolated from porcine brain in a reaction with ATP and microtubules. Ciliobrevin-D as control. | 96-endpoint (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS063 |
Actin (skeletal muscle) polymerization | Pyrene muscle actin (AP05) | 96 assays (5 IC50s + 1 control) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS080 |
Actin (skeletal muscle) polymerization | Pyrene muscle actin (AP05) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS081 |
Actin (non-muscle) polymerization | 90% non-muscle actin (APHL99, beta:gamma isoforms in 4:1 ratio), plus 10% pyrene muscle actin (AP05) as a marker. | 96 assays (5 IC50s + 1 control) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS082 |
Actin (non-muscle) polymerization | 90% non-muscle actin (APHL99, beta:gamma isoforms in 4:1 ratio), plus 10% pyrene muscle actin (AP05) as a marker. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS083 |
F-Actin Binding Spin-down Assays (skeletal muscle actin) | Rabbit skeletal muscle actin. | 24 assays (10 duplicates, four controls. | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS090 |
F-Actin Binding Spin-down Assays (non muscle actin) | Bovine spleen non-muscle actin (ABS99) or human platelet non-muscle actin (APHL99). | 24 assays (10 duplicates, four controls. | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS091 |
GEF Assays | hDBS with Rho or Cdc42, or ARNO with Arf1 a-del13 or Arf6 a-del17. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS100 |
GAP Assays | p50 Rho GAP with Rho, Rac or Cdc42, or other provided GAP / small G-protein combination. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS105 |
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Tubulin ELISA (alpha) (total tubulin) | Anti-alpha-tubulin mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS200 |
Tubulin ELISA (beta I, II, III, IV, V or VI) | Anti-beta-tubulin isoform mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS201 |
Tubulin ELISA (acetylated alpha) | Anti-acetylated tubulin mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS202 |
Tubulin ELISA (glutamylated) | Anti-glutamylated tubulin mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS203 |
Tubulin ELISA (glycinated) | Anti-glycinated tubulin mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS204 |
Tubulin ELISA (tyrosinated) | Anti-tyrosinated tubulin mouse monoclonal antibody. | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS205 |
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GLISA with extracts provided by Customer | Rho, Rac, Cdc42, Ras, Ral, Arf1 or Arf6 GLISA kit. | 48 assays (20 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS220 |
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GLISA with extracts made at Cytoskeleton | Rho, Rac, Cdc42, Ras, Ral, Arf1 or Arf6 GLISA Kit. | 48 assays (20 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 6 | CDS221 |
RhoA ELISA (total RhoA) | Rho ELISA Kit (BK150) | 96 assays (40 duplicates + 4 Controls + 4 blanks) | PDF report with Executive Summary, Introduction, Methods, Results and Data Analysis. | 3 | CDS222 |
Cytoskeleton provides custom services on a confidential basis, as such there are limited published citations of our work. Representative examples of publications coming from our services are 1) Tubulin polymerization assays (ref.1) and plant tubulin purification (ref.2). We can also provide professional references of services performed upon request.
References:
1) In Vitro and In Vivo Anticancer Activities of Synthetic Macrocyclic Ketone Analogues of Halichondrin B1. CANCER RESEARCH 61, 1013–1021, February 1, 2001. Murray J. Towle, Kathleen A. Salvato, Jacqueline Budrow, Bruce F. Wels, Galina Kuznetsov, Kimberley K. Aalfs, Susan Welsh, Wanjun Zheng, Boris M. Seletsky, Monica H. Palme, Gregory J. Habgood, Lori A. Singer, Lucian V. DiPietro, Yuan Wang, Jack J. Chen, David A. Quincy, Ashley Davis, Kentaro Yoshimatsu, Yoshito Kishi, Melvin J. Yu, and Bruce A. Littlefield (2001).
2) The herbicide flamprop-M-methyl has a new antimicrotubule mechanism of action.Stefan Tresch, Ricarda Niggeweg and Klaus Grossmann. Pest Manag Sci 64: 1195–1203 (2008).
Cytoskeleton, Inc. has been a reliable source of protein, assays and drug screening services for nearly two decades. Past clients include:
Merck Eli Lilly Eisai Amgen Abbott Labs Zentaris GlaxoSmithKline
Genentech Johnson & Johnson Bristol-Myers Squibb Pfizer Wyeth
If you have an immediate question please send an e-mail describing your requirements to tservice@cytoskeleton.com.