Cytoskeleton Inc Kit and Assay Validation Data and Citations

Kit Citations

AuthorTitleJournalYearArticle Link
Joseph, Jesvin et al.Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR)Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2024
Chanez-Paredes, Sandra D. et al.Mechanisms underlying distinct subcellular localization and regulation of epithelial long myosin light-chain kinase splice variantsJournal of Biological Chemistry2024
Szpak, Dorota et al.Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeletonBlood Advances2023
DeGiosio, R. A. et al.Differential regulation of MAP2 by phosphorylation events in proline-rich versus C-terminal domainsThe FASEB Journal2023
Duan, Xudong et al.Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongationCell Reports2021
Yan, Yanling et al.RTKN-1/rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recyclingJournal of Cell Biology2021
Lu, Yi Ju et al.Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunityNature Communications2020
Park, Jin Suk et al.Mechanical regulation of glycolysis via cytoskeleton architectureNature2020
Gabel, Marion et al.Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cellsBiochimica et Biophysica Acta - Molecular Cell Research2019
Afreen, Sana et al.Altered Cytoskeletal Composition and Delayed Neurite Elongation in tau45–230-Expressing Hippocampal NeuronsNeuroscience2019
Krueger, Daniel et al.Cross-linker–mediated regulation of actin network organization controls tissue morphogenesisJournal of Cell Biology2019
Mao, Bai Ping et al.CaMSAP2 is a microtubule minus-end targeting protein that regulates BTB dynamics through cytoskeletal organizationEndocrinology2019
Zhang, Min et al.Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2Neuron2019
Wen, Qing et al.Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testisCell Death and Disease2018
Bardai, Farah H. et al.A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutations in vivoJournal of Neuroscience2018
Kschonsak, Yvonne T. et al.Activated ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientationJournal of Cell Science2018
Leelarasamee, Natthanon et al.The root-knot nematode effector MiPFN3 disrupts plant actin filaments and promotes parasitismPLoS Pathogens2018
Gong, Ting et al. PTRN ‐1/ CAMSAP promotes CYK ‐1/formin‐dependent actin polymerization during endocytic recycling The EMBO Journal2018
Shioda, Norifumi et al.Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome articleNature Medicine2018
Loukil, Abdelhalim et al.Foci of cyclin A2 interact with actin and RhoA in mitosisScientific Reports2016
Feng, Di et al.Functional validation of an alpha-actinin-4 mutation as a potential cause of an aggressive presentation of adolescent focal segmental glomerulosclerosis: Implications for genetic testingPLoS ONE2016
Gao, Ying et al.Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cellsScientific Reports2016
Wang, Peixiang et al.RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling EndosomesPLoS Genetics2016
Tie, S. R. et al.Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathwayOncogene2016
Li, Nan et al.Overexpression of plastin 3 in Sertoli cells disrupts actin microfilament bundle homeostasis and perturbs the tight junction barrierSpermatogenesis2016
Gabel, Marion et al.Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosisJournal of Cell Biology2015
Li, Nan et al.Formin 1 regulates ectoplasmic specialization in the rat testis through its actin nucleation and bundling activityEndocrinology (United States)2015
Li, Nan et al.Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testisFASEB Journal2015
Calvo, Fernando et al.Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated FibroblastsCell Reports2015
Lin, Wei Chi et al.Actin-binding protein G (AbpG) participates in modulating the actin cytoskeleton and cell migration in Dictyostelium discoideumMolecular Biology of the Cell2015
Delorme-Walker, Violaine et al.Chronophin coordinates cell leading edge dynamics by controlling active cofilin levelsProceedings of the National Academy of Sciences of the United States of America2015
Kang, Yongsung et al.HopW1 from Pseudomonas syringae Disrupts the Actin Cytoskeleton to Promote Virulence in ArabidopsisPLoS Pathogens2014
Clarke, Joseph P. et al.Cell Stress Promotes the Association of Phosphorylated HspB1 with F-ActinPLoS ONE2013
Zhu, Mei et al.MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progressionJournal of Cell Biology2013
Kitagawa, Mayumi et al.Targeting Aurora B to the Equatorial Cortex by MKlp2 Is Required for CytokinesisPLoS ONE2013
Wolter, Patrick et al.GAS2L3, a target gene of the DREAM complex, is required for proper cytokinesis and genomic stabilityJournal of cell science2012
Munsie, Lise Nicole et al.Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stressJournal of Cell Science2012
Marat, Andrea L. et al.Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeletonMolecular Biology of the Cell2012
Trulsson, Maria et al.HAMLET Binding to α-Actinin Facilitates Tumor Cell DetachmentPLOS ONE2011
Pang, Te Ling et al.Costars, a Dictyosteliumprotein similar to the C-terminal domain of STARS, regulates the actin cytoskeleton and motilityJournal of Cell Science2010
Davis, David A. et al.Capzb2 interacts with β-tubulin to regulate growth cone morphology and neurite outgrowthPLoS Biology2009
Gohla, Antje et al.Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamicsNature cell biology2005
Falcón-Pérez, Juan M. et al.BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granulesThe Journal of biological chemistry2002
Zhai, Liwei et al.Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeletonThe Journal of biological chemistry2001
Leung, Conrad L. et al.Microtubule Actin Cross-Linking Factor (Macf)A Hybrid of Dystonin and Dystrophin That Can Interact with the Actin and Microtubule CytoskeletonsJournal of Cell Biology1999
AuthorTitleJournalYearArticle Link
Jiménez-Guerrero, Irene et al.Natural variation in a short region of the Acidovorax citrulli type III-secreted effector AopW1 is associated with differences in cytotoxicity and host adaptationThe Plant Journal2024
Alburquerque-González, Begoña et al.Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathwayBiomedicine & Pharmacotherapy2024
Yang, Panpan et al.Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis developmentBone Research2024
Mohamed, Muhaned S. et al.Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundlingProceedings of the National Academy of Sciences2023
Wolf, Marc et al.S100A8/S100A9 Integrates F-Actin and Microtubule Dynamics to Prevent Uncontrolled Extravasation of LeukocytesBiomedicines2023
Duan, Xudong et al.Essential role of the endocytic site-associated protein Ecm25 in stress-induced cell elongationCell Reports2021
Yasuda, Hidenori et al.Tacrolimus ameliorates podocyte injury by restoring FK506 binding protein 12 (FKBP12) at actin cytoskeletonThe FASEB Journal2021
Cousin, M A et al.Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndromeNature …2021
Lu, Yi Ju et al.Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunityNature Communications2020
Alburquerque-González, Begoña et al.New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cellsExperimental and Molecular Medicine2020
Afreen, Sana et al.Altered Cytoskeletal Composition and Delayed Neurite Elongation in tau 45-230-Expressing Hippocampal NeuronsNeuroscience2019
Wang, Guang et al.Rab7 regulates primary cilia disassembly through cilia excisionJournal of Cell Biology2019
Kumar, M. Nagaraj et al.Low water potential and AT14A-like1 (AFL1) effects on endocytosis and actin filament organizationPlant Physiology2019
Fu, Chuntang et al.JMJD3 regulates CD4+ T cell trafficking by targeting actin cytoskeleton regulatory gene Pdlim4Journal of Clinical Investigation2019
Balta, Emre et al.Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cellsNature Communications2019
Laitila, Jenni et al.A nebulin super-repeat panel reveals stronger actin binding toward the ends of the super-repeat regionMuscle and Nerve2019
Wen, Qing et al.Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testisCell Death and Disease2018
Bardai, Farah H. et al.A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutations in vivoJournal of Neuroscience2018
Schaffer, Ashleigh E. et al.Biallelic loss of human CTNNA2, encoding αN-catenin, leads to ARP2/3 complex overactivity and disordered cortical neuronal migrationNature Genetics2018
Da’as, Sahar I. et al.Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interactionBiochemical Journal2018
Cervero, Pasquale et al.Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breakingNature Communications2018
Wu, Tongbin et al.HSPB7 is indispensable for heart development by modulating actin filament assemblyProceedings of the National Academy of Sciences of the United States of America2017
Guan, Liying et al.The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell ProtrusionsPLoS Genetics2016
Szeto, Sandy G.Y. et al.Phosphorylation of filamin A by Cdk1 regulates filamin A localization and daughter cell separationExperimental Cell Research2015
Yan, Yi et al.Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5Nature Communications2015
Kumeta, Masahiro et al.Caprice/MISP is a novel F-actin bundling protein critical for actin-based cytoskeletal reorganizationsGenes to Cells2014
Mokbel, Nancy et al.K7del is a common TPM2 gene mutation associated with nemaline myopathy and raised myofibre calcium sensitivityBrain2013
Wang, Tzu Fan et al.Identification and characterization of the actin-binding motif of PhostensinInternational Journal of Molecular Sciences2012
Lai, Ning Sheng et al.Phostensin caps to the pointed end of actin filaments and modulates actin dynamicsBiochemical and Biophysical Research Communications2009
Meira, Maria et al.Memo is a cofilin-interacting protein that influences PLCγ1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migrationJournal of Cell Science2009
McCloskey, Diana T. et al.Hypotonic activation of short ClC3 isoform is modulated by direct interaction between its cytosolic C-terminal tail and subcortical actin filamentsJournal of Biological Chemistry2007
Takeshita, Norio et al.CsmA, a Class V Chitin Synthase with a Myosin Motor-like Domain, Is Localized through Direct Interaction with the Actin Cytoskeleton in Aspergillus nidulansMolecular Biology of the Cell2005
Terry-Lorenzo, Ryan T. et al.Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturationMolecular Biology of the Cell2005
Torgler, Catherine N. et al.Tensin Stabilizes Integrin Adhesive Contacts in DrosophilaDevelopmental Cell2004
Kumar, Narendra et al.Association of villin with phosphatidylinositol 4,5-bisphosphate regulates the actin cytoskeletonThe Journal of biological chemistry2004
Banerjee, Jayashree et al.Identification of a Novel Sequence in PDZ-RhoGEF That Mediates Interaction with the Actin CytoskeletonMolecular Biology of the Cell2004
Goryunov, Dmitry et al.Studying cytolinker proteinsMethods in Cell Biology2004
Oliver, Carey J. et al.Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell MorphologyMolecular and Cellular Biology2002
Hildebrand, Jeffrey D. et al.Shroom, a PDZ Domain–Containing Actin-Binding Protein, Is Required for Neural Tube Morphogenesis in MiceCell1999
AuthorTitleJournalYearArticle Link
Lyu, Jialan et al.Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signallingTheranostics2024
Akter, Tanjina et al.IQGAP1 Regulates Actin Polymerization and Contributes to Bleomycin-Induced Lung FibrosisInternational Journal of Molecular Sciences2024
Huang, Xuejiao et al.Polyglutamine Binding Protein 1 regulates neurite outgrowth through recruiting N-WASPJournal of Biological Chemistry2024
Kumar, Raj et al.Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular LeakageArteriosclerosis, Thrombosis, and Vascular Biology2024
Formánek, Bedřich et al.Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moietyRSC Medicinal Chemistry2024
Chand, Abhishu et al.CdSe/ZnS Quantum Dots’ Impact on In Vitro Actin DynamicsInternational Journal of Molecular Sciences 2024
Chanez-Paredes, Sandra D. et al.Mechanisms underlying distinct subcellular localization and regulation of epithelial long myosin light-chain kinase splice variantsJournal of Biological Chemistry2024
Scanlon, Kaylyn R. et al.Chlamydia trachomatis TmeB antagonizes actin polymerization via direct interference with Arp2/3 activityFrontiers in Cellular and Infection Microbiology2023
Coverdale, J. P.C. et al.Triplex metallohelices have enantiomer-dependent mechanisms of action in colon cancer cellsDalton Transactions2023
Tian, Huayang et al.Phase separation of S-RNase promotes self-incompatibility in Petunia hybridaJournal of Integrative Plant Biology2023
Zhang, Qing et al.Membrane-dependent actin polymerization mediated by the Legionella pneumophila effector protein MavHPLOS Pathogens2023
Bogucka-Janczi, Katarzyna et al.ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization.eLife2023
Ángeles-Robles, Gabriela et al.Actin protein inside DMPC GUVs and its mechanical response to AC electric fieldsBiochimica et Biophysica Acta (BBA) - Biomembranes2022
Geng, Mengxin et al.Synthesis and characterization of semisynthetic analogs of the antifungal occidiofunginFrontiers in Microbiology2022
Chen, Binghong et al.Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signalingJournal of Experimental and Clinical Cancer Research2022
Wang, Baolei et al.Numb and Numblike regulate sarcomere assembly and maintenanceJournal of Clinical Investigation2022
Hsiao, Bo Yuan et al.Human costars family protein abracl modulates actin dynamics and cell migration and associates with tumorigenic growthInternational Journal of Molecular Sciences2021
Misra, Suniti et al.Periostin/Filamin-A: A Candidate Central Regulatory Axis for Valve Fibrogenesis and Matrix CompactionFrontiers in Cell and Developmental Biology2021
Bock, Fabian et al.Rac1 promotes kidney collecting duct integrity by limiting actomyosin activityJournal of Cell Biology2021
Yan, Yanling et al.RTKN-1/rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recyclingJournal of Cell Biology2021
Sarkar, Souvarish et al.Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivoMolecular Neurodegeneration2021
Shimura, Daisuke et al.Protective mitochondrial fission induced by stress-responsive protein GJA1-20keLife2021
Chen, Yuewen et al.Coronin 2B regulates dendrite outgrowth by modulating actin dynamicsFEBS Letters2020
Kang, Dong Hee et al.Down-regulation of diesel particulate matter-induced airway inflammation by the PDZ motif peptide of ZO-1Journal of Cellular and Molecular Medicine2020
Lamm, Noa et al.Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stressNature Cell Biology2020
Schneidewind, Tabea et al.The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented ChemotypeCell Chemical Biology2019
Limatola, Nunzia et al.Nicotine Induces Polyspermy in Sea Urchin Eggs through a Non-Cholinergic Pathway Modulating Actin DynamicsCells2019
Li, Linxi et al.Planar cell polarity protein Dishevelled 3 (Dvl3) regulates ectoplasmic specialization (ES) dynamics in the testis through changes in cytoskeletal organizationCell Death and Disease2019
Liu, Juan et al.CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated GlycolysisImmunity2019
Li, Lin Xi et al.Regulation of blood-testis barrier dynamics by the mTORC1/rpS6 signaling complex: An in vitro studyAsian Journal of Andrology2019
Lang, Lei et al.ATM-Mediated phosphorylation of cortactin involved in actin polymerization promotes breast cancer cells migration and invasionCellular Physiology and Biochemistry2019
Zhang, Min et al.Axonogenesis Is Coordinated by Neuron-Specific Alternative Splicing Programming and Splicing Regulator PTBP2Neuron2019
Ravichandran, Akshaya et al.A novel actin binding drug with in vivo efficacyAntimicrobial Agents and Chemotherapy2019
Kommaddi, Reddy Peera et al.Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in alzheimer’s diseaseJournal of Neuroscience2018
Wen, Qing et al.Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testisCell Death and Disease2018
Bardai, Farah H. et al.Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamicsPLoS Biology2018
Gau, David et al.Structure-based virtual screening identifies a small-molecule inhibitor of the profilin 1–actin interactionJournal of Biological Chemistry2018
Shioda, Norifumi et al.Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome articleNature Medicine2018
Kim, Mi Seon et al.Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor actionOncotarget2018
Patel, Vaibhav B. et al.PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart diseaseNature Communications2018
Kumar, Dhivya et al.Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzymeScientific Reports2018
Sarowar, Tasnuva et al.Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2Frontiers in Molecular Neuroscience2017
Misiak, Majus et al.Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7Oncotarget2017
Tormos, Ana M. et al.P38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and agingPLoS ONE2017
Wu, Tongbin et al.HSPB7 is indispensable for heart development by modulating actin filament assemblyProceedings of the National Academy of Sciences of the United States of America2017
Kumar, Raj et al.A new role for cofilin in retinal neovascularizationJournal of Cell Science2016
Sarowar, Tasnuva et al.Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2Molecular Brain2016
Kpetemey, Marilyne et al.MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamicsOncotarget2016
Rondina, M. T. et al.Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human plateletsJournal of Thrombosis and Haemostasis2016
Chakraborty, Sayan et al.An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinomaNature Communications2015
Jiang, Shiyou et al.A group of ent-Kaurane diterpenoids inhibit hedgehog signaling and induce cilia elongationPLoS ONE2015
Henkels, Karen M. et al.S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid bindingFASEB Journal2015
Lin, Wei Chi et al.Actin-binding protein G (AbpG) participates in modulating the actin cytoskeleton and cell migration in Dictyostelium discoideumMolecular Biology of the Cell2015
Odermatt, Pascal D. et al.High-Resolution Correlative Microscopy: Bridging the Gap between Single Molecule Localization Microscopy and Atomic Force MicroscopyNano Letters2015
Lutz, Vanessa et al.SAR studies on hydropentalene derivatives - Important core units of biologically active tetramic acid macrolactams and ptychanolidesBioorganic and Medicinal Chemistry2014
Chan, Eddie et al.The acetylenic tricyclic bis(cyano enone), TBE-31 inhibits non-small cell lung cancer cell migration through direct binding with actinCancer Prevention Research2014
Speranza, Francis et al.The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase DJournal of Biological Chemistry2014
La Clair, James J. et al.In Situ natural product discovery via an artificial marine spongePLoS ONE2014
Nievergelt, Adrian P. et al.High-frequency multimodal atomic force microscopyBeilstein Journal of Nanotechnology2014
Yuan, Baiyin et al.A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in miceAmerican Journal of Pathology2014
Taniuchi, Keisuke et al.RUVBL1 directly binds actin filaments and induces formation of cell protrusions to promote pancreatic cancer cell invasionInternational Journal of Oncology2014
Xiao, Xiang et al.c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution2013
Jiwani, Shahanawaz et al.Chlamydia trachomatis Tarp cooperates with the Arp2/3 complex to increase the rate of actin polymerizationBiochemical and Biophysical Research Communications2012
Fan, Jianguo et al.A role for γs-crystallin in the organization of actin and fiber cell maturation in the mouse lensFEBS Journal2012
Butler, Suzanne C. et al.Inhibitory effects of pectenotoxins from marine algae on the polymerization of various actin isoformsToxicology in Vitro2012
Perisic, Ljubica et al.Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamicsKidney International2012
Xavier, Charles Peter et al.Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migrationScientific Reports2012
Trigili, Chiara et al.Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and JChemBioChem2011
Tsai, Chih Chien et al.7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migrationBiochemical Pharmacology2011
Peterson, Jon E. et al.Normal ranges of angiogenesis regulatory proteins in human plateletsAmerican Journal of Hematology2010
Lai, Ning Sheng et al.Phostensin caps to the pointed end of actin filaments and modulates actin dynamicsBiochemical and Biophysical Research Communications2009
Chellaiah, Meenakshi A. et al.Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorptionJournal of Biological Chemistry2007
Nusco, Gilda A. et al.Modulation of calcium signalling by the actin-binding protein cofilinBiochemical and Biophysical Research Communications2006
Takamiya, Rina et al.Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal changeAmerican journal of physiology. Cell physiology2005
Chellaiah, Meenakshi A.Regulation of actin ring formation by Rho GTPases in osteoclastsJournal of Biological Chemistry2005
Kumar, Narendra et al.Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villinThe Journal of biological chemistry2004
Nielsen, Finn C. et al.Cytoplasmic trafficking of IGF-II mRNA-binding protein by conserved KH domainsJournal of Cell Science2002
Zhai, Liwei et al.Tyrosine phosphorylation of villin regulates the organization of the actin cytoskeletonThe Journal of biological chemistry2001
Fontao, Lionel et al.The interaction of plectin with actin: evidence for cross-linking of actin filaments by dimerization of the actin-binding domain of plectinJournal of cell science2001
Blader, Ira J. et al.GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitroMolecular Biology of the Cell1999
AuthorTitleJournalYearArticle Link
Chang, Yun et al.Engineered human pluripotent stem cell-derived natural killer cells with PD-L1 responsive immunological memory for enhanced immunotherapeutic efficacyBioactive Materials2023
Harris, Jackson D. et al.Engineered anti-prostate cancer CAR-neutrophils from human pluripotent stem cellsJournal of Immunology and Regenerative Medicine2023
Chang, Yun et al.CAR-neutrophil mediated delivery of tumor-microenvironment responsive nanodrugs for glioblastoma chemo-immunotherapyNature Communications2023
Daso, Rachel E. et al.Self-Assembled Peptide-Based Biocomposites for Near-Infrared Light Triggered Drug Release to Tumor CellsBiotechnology Journal2020
Lucas, Erin D. et al.PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin ImmunityCell Reports2020
Choi, Seungho et al.Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathologyFASEB Journal2020
Verboon, Jeffrey M. et al.Infantile Myelofibrosis and Myeloproliferation with CDC42 DysfunctionJournal of Clinical Immunology2020
Choi, Seungho et al.Regulation of endothelial barrier integrity by redox-dependent nitric oxide signaling: Implication in traumatic and inflammatory brain injuriesNitric Oxide - Biology and Chemistry2019
Gao, Chong et al.Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cellsBreast Cancer Research2019
Hu, Ruixi et al.RNA-binding protein PUM2 suppresses osteosarcoma progression via partly and competitively binding to STARD13 3′UTR with miRNAsCell Proliferation2018
Gao, Fei et al.STARD13 is positively correlated with good prognosis and enhances 5-FU sensitivity via suppressing cancer stemness in hepatocellular carcinoma cellsOncoTargets and Therapy2018
Kundu, Nandini et al.Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathwayOncotarget2017
Jenkins, Edmund C. et al.Na+/H+ exchanger 1 (NHE1) function is necessary for maintaining mammary tissue architectureDevelopmental Dynamics2014
Asahara, S. et al.Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actinDiabetologia2013
Arita, Ryoichi et al.A key role for ROCK in TNF-α-mediated diabetic microvascular damageInvestigative Ophthalmology and Visual Science2013
Valtcheva, Nadejda et al.The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42Journal of Biological Chemistry2013
Ren, Wen Wen et al.Stimulation of α2A-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortexMolecular and Cellular Neuroscience2012
Spangler, Barbara et al.ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanomaInternational Journal of Cancer2012
Haidari, Mehran et al.Inhibition of MLC phosphorylation restricts replication of influenza virus-a mechanism of action for anti-influenza agentsPLoS ONE2011
Isik, Nilgun et al.An Elmo-like Protein Associated with Myosin II Restricts Spurious F-Actin Events to Coordinate Phagocytosis and ChemotaxisDevelopmental Cell2008
AuthorTitleJournalYearArticle Link
Iwanski, Jessika B. et al.Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunctionnpj Regenerative Medicine2024
Jiménez-Guerrero, Irene et al.Natural variation in a short region of the Acidovorax citrulli type III-secreted effector AopW1 is associated with differences in cytotoxicity and host adaptationThe Plant Journal2024
Reedy, Jennifer L. et al.Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxingNature Communications 2024
Eberhard, Daniel et al.Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosisNature Cardiovascular Research 2024
Przyklenk, Matthias et al.ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorderScientific Reports 2024
Song, Yang et al.Biphasic regulation of epigenetic state by matrix stiffness during cell reprogrammingScience Advances2024
Politiek, Frouwkje A. et al.Molecular and cellular consequences of mevalonate kinase deficiencyBiochimica et Biophysica Acta (BBA)2024
Müller, Lisa et al.Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tensionCellular and Molecular Life Sciences2024
Liu, Xiaomin et al.RABV induces biphasic actin cytoskeletal rearrangement through Rac1 activity modulationJournal of Virology2024
Wang, Kui et al.Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regenerationRegenerative Biomaterials2024
Sen, Buer et al.Nuclear actin structure regulates chromatin accessibilityNature Communications2024
Baudouin, Lucas et al.Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane expansion in oligodendrocytesGLIA2024
Gao, Da Peng et al.Chronic Alcohol Exposure Alters the Levels and Assembly of the Actin Cytoskeleton and Microtubules in the Adult Mouse HippocampusJournal of Integrative Neuroscience2024
Kamnev, Anton et al.Coordinated ARP2/3 and glycolytic activities regulate the morphological and functional fitness of human CD8+ T cellsCell reports2024
Yin, Xiufeng et al.CFL1 is Implicated in Chronic Myeloid Leukemia Response during Imatinib TherapyJournal of Cancer2024
Medina-Dols, Aina et al.Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axisCell Death Discovery 2024
Li, Yuan Bao et al.Fimbrin associated with Pmk1 to regulate the actin assembly during Magnaporthe oryzae hyphal growth and infectionStress Biology2024
Wang, Lingling et al.Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actinReproductive Biology and Endocrinology 2024
Yu, Jinhan et al.Inhibiting F-Actin Polymerization Impairs the Internalization of Moraxella catarrhalisMicroorganisms 2024
Kinnart, Inge et al.Elevated α-synuclein levels inhibit mitophagic fluxnpj Parkinson's Disease2024
Qu, Jiaorong et al.The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodelingSignal Transduction and Targeted Therapy2023
Li Mow Chee, Frederic et al.Mena regulates nesprin-2 to control actin–nuclear lamina associations, trans-nuclear membrane signalling and gene expressionNature Communications2023
Djaziri, Nabila et al.Cleavage of periostin by MMP9 protects mice from kidney cystic diseasePLOS ONE2023
Hsu, Hong Ming et al.Distinct features of the host-parasite interactions between nonadherent and adherent Trichomonas vaginalis isolatesPLOS Neglected Tropical Diseases2023
Chen, Yen Ju et al.PIP2 regulating calcium signal modulates actin cytoskeleton-dependent cytoadherence and cytolytic capacity in the protozoan parasite Trichomonas vaginalisPLOS Pathogens2023
Wang, Kai-Hsuan et al.An Atypical F-Actin Capping Protein Modulates Cytoskeleton Behaviors Crucial for Trichomonas vaginalis ColonizationMicrobiology Spectrum2023
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Halpert, Michal et al.Rac-dependent doubling of HeLa cell area and impairment of cell migration and cell cycle by compounds from Iris germanicaProtoplasma2011
May, James M.The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin CBritish Journal of Pharmacology2011
Lichtenstein, Mathieu P. et al.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivativesJournal of Alzheimer's disease : JAD2010
Johanna, Gutiérrez Vargas et al.Rac1 activity changes are associated with neuronal pathology and spatial memory long-term recovery after global cerebral ischemiaNeurochemistry international2010
Ridgway, Lon D. et al.Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma CellsJournal of cellular biochemistry2010
Romero, Ana M. et al.Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary cultureToxicological Sciences2010
Fang, Xiaohui et al.Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1Journal of Biological Chemistry2010
Zhu, Jianxin et al.P21-Activated Kinases Regulate Actin Remodeling in Glomerular PodocytesAmerican Journal of Physiology - Renal Physiology2010
Baumer, Y. et al.Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdownJournal of Cellular Physiology2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Mercer, Jason et al.Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cellsScience (New York, N.Y.)2008
Pontow, Suzanne et al.Antiviral Activity of a Rac GEF inhibitor Characterized with a Sensitive HIV/SIV Fusion AssayVirology2007
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Morstein, Johannes et al.Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket.Cell2024
Yin, Zhao et al.Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse modelInternational Journal of Biological Sciences2023
Hiatt, Susan M. et al.De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delayPLoS Genetics2018
Gu, Chunming et al.RalA, a GTPase targeted by miR‑181a, promotes transformation and progression by activating the Ras‑related signaling pathway in chronic myelogenous leukemiaOncotarget2016
Papini, Diana et al.TD-60 links RalA GTPase function to the CPC in mitosisNature Communications 2015 6:12015
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Bergoug, Mohammed et al.An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site SelectionJournal of Molecular Biology2024
Puliga, Elisabetta et al.Biological and targeting differences between the rare KRAS A146T and canonical KRAS mutants in gastric cancer modelsGastric Cancer2024
Popescu, Bogdan et al.Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AMLCell reports. Medicine2023
Li, Tianxia et al.Developing SHP2-based combination therapy for KRAS-amplified cancerJCI Insight2023
Baltanás, Fernando C. et al.Critical requirement of SOS1 for tumor development and microenvironment modulation in KRASG12D-driven lung adenocarcinomaNature Communications2023
Peng, Ke et al.Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric CancerClinical Cancer Research2023
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Swaminathan, Bhairavi et al.Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migrationScientific Reports2022
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Mao, De Yu et al.CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and functionScience Signaling2021
Tisi, Renata et al.The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetux****-Resistant Cancer CellsFrontiers in Molecular Biosciences2021
Hofmann, Marco H. et al.Bi-3406, a potent and selective sos1–kras interaction inhibitor, is effective in kras-driven cancers through combined mek inhibitionCancer Discovery2021
Wang, Xuesong et al.Sevof****** inhibits growth factor-induced angiogenesis through suppressing Rac1/paxillin/FAK and Ras/Akt/mTORFuture oncology (London, England)2020
Kim, Jin Hee et al.Rational design of small molecule RHOA inhibitors for gastric cancerThe Pharmacogenomics Journal2020
Lu, Hengyu et al.Research paper resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFROncotarget2020
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Casique-Aguirre, Diana et al.KRas4B-PDE6δ complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer 06 Biological Sciences 0601 Biochemistry and Cell BiologyBMC Cancer2018
Li, Qing fen et al.Activation of Ras in the Vascular Endothelium Induces Brain Vascular Malformations and Hemorrhagic StrokeCell Reports2018
Zhao, Tuo et al.Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-κB and ERK1/2 PathwaysInternational Journal of Molecular Sciences2018
Wong, Gabrielle S. et al.Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition letterNature Medicine2018
Chen, Guo Ping et al.Inhibition of farnesyl pyrophosphate synthase attenuates high glucose-induced vascular smooth muscle cells proliferationMolecular Medicine Reports2017
Huang, Jia Lin et al.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosisNature Communications2017
Zhao, Chen Ze et al.Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodelingScientific Reports2016
Lee, Sei Jung et al.Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5The Journal of Biological Chemistry2013
Camargo, Livia De Lucca et al.Endo-PDI is required for TNFα-induced angiogenesisFree Radical Biology and Medicine2013
Chen, Bin et al.Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fractionCellular Physiology and Biochemistry2013
Gil-Henn, H. et al.Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivoOncogene2013
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Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Sucre, Jennifer M.S. et al.Alveolar repair following LPS-induced injury requires cell-ECM interactionsJCI Insight2023
Zhu, Lingxin et al.Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorptionJournal of Cell Biology2023
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Hassin, Ori et al.Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patientsNature Communications2022
Nataraj, Nishanth Belugali et al.Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factorsCell Reports2022
Walter, Lisa Marie et al.Profilin2 regulates actin rod assembly in neuronal cellsScientific Reports2021
Rogg, Manuel et al.SRGAP1 controls small rho GTPases to regulate podocyte foot process maintenanceJournal of the American Society of Nephrology2021
Ghosh, Soma et al.PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFRCell Reports2021
Rodríguez-Fdez, Sonia et al.Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in LymphocytesCells2020
Hung, Pei Shan et al.The inhibition of Wnt restrain KRASG12V-driven metastasis in non-small-cell lung cancerCancers2020
Lorenzo-Martín, L. Francisco et al.VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinomaNature Communications2020
Lee, Mi Nam et al.The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activationStem Cell Research2020
Lorenzo-Martín, L. Francisco et al.Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factorOncogene2020
Atala, AnthonyRe: MicroRNA-141 Suppresses Prostate Cancer Stem Cells and Metastasis by Targeting a Cohort of Pro-Metastasis GenesThe Journal of urology2017
Cerikan, Berati et al.Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase RegulatorDevelopmental Cell2016
Sarowar, Tasnuva et al.Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2Molecular Brain2016
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Wang, Ting Ching et al.Genetic variation drives cancer cell adaptation to ECM stiffnessProceedings of the National Academy of Sciences2024
Wang, Hongyun et al.Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL PathwayAmerican Journal of Nephrology2024
Tokic, Silvija et al.The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial endothelial cells altered by gestational diabetes mellitusThe Journal of Physiology2024
Kim, Hugh et al.Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chainBiochemical Journal2024
Wang, Huogang et al.Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironmentExperimental Hematology & Oncology2024
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Kumari, Reena et al.Focal adhesions contain three specialized actin nanoscale layersNature Communications 2024
Koenis, Duco Steven et al.Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of GlycolysisAdvanced Science2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Vahldieck, Carl et al.Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axisFrontiers in Immunology2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Han, Xuedan et al.Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathwayJournal of Pharmaceutical Analysis2024
Zhang, Jiahui et al.Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoAPhytotherapy Research2024
Bock, Fabian et al.Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entryScience advances2024
Moztarzadeh, Sina et al.Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activationScientific Reports2024
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Yue, Xianlin et al.Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescenceCell Death Discovery2023
Safavian, Darya et al.Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zoneJournal of Cell Biology2023
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Huang, Xinyi et al.Actomyosin-dependent cell contractility orchestrates Zika virus infectionJournal of Cell Science2023
González, Yasmilde Rodríguez et al.PFTK1 kinase regulates axogenesis during development via RhoA activationBMC Biology2023
Ye, Qian et al.Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male miceNature Communications2023
Werder, Rhiannon B. et al.The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cellsAmerican journal of human genetics2023
Toffali, Lara et al.An isoform of the giant protein titin is a master regulator of human T lymphocyte traffickingCell reports2023
Bartos, Katalin et al.Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activityJournal of Cell Communication and Signaling2023
Escuin, Sarah et al.Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouseDMM Disease Models and Mechanisms2023
Dang, Iren et al.Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Journal of Cell Science2023
Martínez-Rendón, Jacqueline et al.Ouabain Induces Transcript Changes and Activation of RhoA/ROCK Signaling in Cultured Epithelial Cells (MDCK)Current Issues in Molecular Biology2023
Rogg, Manuel et al.A YAP/TAZ–ARHGAP29–RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin AdhesionsCells2023
Choi, Hyehun et al.LRRC8A anion channels modulate vascular reactivity via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)FASEB journal : official publication of the Federation of American Societies for Experimental Biology2023
Lopes-Rodrigues, Vanessa et al.AraC interacts with p75NTR transmembrane domain to induce cell death of mature neuronsCell Death & Disease2023
Zhai, Ruoyang et al.Effects of sevof****** on lung epithelial permeability in experimental models of acute respiratory distress syndromeJournal of Translational Medicine2023
Crespo, Grace Velez et al.The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancerMolecular Medicine2023
Morishita, Jun et al.Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cellsOpen Biology2023
Anastasaki, Corina et al.Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterizationSTAR Protocols2022
Zanin, Juan P. et al.p75NTR prevents the onset of cerebellar granule cell migration via RhoA activationeLife2022
Sánchez-de la Torre, Aníbal et al.Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in miceCell Death & Disease 2022 13:72022
Weder, Bruce et al.New Therapeutic Approach for Intestinal Fibrosis Through Inhibition of pH-Sensing Receptor GPR4Inflammatory Bowel Diseases2022
Yadav, Vikas et al.Increased MARCKS Activity in BRAF Inhibitor-Resistant Melanoma Cells Is Essential for Their Enhanced Metastatic Behavior Independent of Elevated WNT5A and IL-6 SignalingCancers2022
Kumar, Akhilesh et al.Essential role of Rnd1 in innate immunity during viral and bacterial infectionsCell Death & Disease 2022 13:62022
Wang, Kankai et al.PTBP1 knockdown promotes neural differentiation of glioblastoma cells through UNC5B receptorTheranostics2022
de Vallière, Cheryl et al.pH-Sensing G Protein-Coupled Receptor OGR1 (GPR68) Expression and Activation Increases in Intestinal Inflammation and FibrosisInternational Journal of Molecular Sciences2022
Meng, Zhipeng et al.The Hippo pathway mediates Semaphorin signalingScience Advances2022
Darp, Revati et al.Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesisNature Communications2022
Vadakumchery, Anila et al.The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B CellsFrontiers in Immunology2022
Hauke, Michael et al.Active RhoA Exerts an Inhibitory Effect on the Homeostasis and Angiogenic Capacity of Human Endothelial CellsJournal of the American Heart Association2022
Xue, Tan et al.Effects of Aster B-mediated intracellular accumulation of cholesterol on inflammatory process and myocardial cells in acute myocardial infarctionHellenic Journal of Cardiology2022
Francis, Caitlin R. et al.Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesisNature Communications 2022
Kumar, Akhilesh et al.Essential role of Rnd1 in innate immunity during viral and bacterial infectionsCell Death & Disease2022
Ma, Yuanyuan et al.Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root developmentDevelopment (Cambridge)2021
Jozic, Ivan et al.Glucocorticoid-mediated induction of caveolin-1 disrupts cytoskeletal organization, inhibits cell migration and re-epithelialization of non-healing woundsCommunications Biology2021
Porter, Lauren et al.SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle CellsCells2020
Krueger, Irena et al.Reelin amplifies glycoprotein VI activation and alphaiib beta3 integrin outside-in signaling via PLC Gamma 2 and Rho GTPasesArteriosclerosis, Thrombosis, and Vascular Biology2020
Hasan, Wan Nuraini Wan et al.Annatto-derived tocotrienol promotes mineralization of MC3T3-E1 cells by enhancing BMP-2 protein expression via inhibiting RhoA activation and HMG-CoA reductase gene expressionDrug Design, Development and Therapy2020
Rong, Zhouyi et al.Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine modelsFASEB Journal2020
Lachowski, Dariusz et al.G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell PolarizationFrontiers in Cell and Developmental Biology2020
Dias Gomes, Martim et al.Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrityNature Communications2019
Santhana Kumar, Karthiga et al.TGF-β Determines the Pro-migratory Potential of bFGF Signaling in MedulloblastomaCell Reports2018
Patra, Vijay Kumar et al.The Skin Microbiome: Is It Affected by UV-induced Immune Suppression?Frontiers in Microbiology2016
Herr, Michael J. et al.Tetraspanin CD9 regulates cell contraction and actin arrangement via RhoA in human vascular smooth muscle cellsPLoS ONE2014
Biechler V., Stefanie V. et al.The impact of flow-induced forces on the morphogenesis of the outflow tractFrontiers in Physiology2014
Mackay, Joanna L. et al.Simultaneous and independent tuning of RhoA and Rac1 activity with orthogonally inducible promotersIntegrative Biology (United Kingdom)2014
Papke, Christina L. et al.Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-βHuman Molecular Genetics2013
Tan, Hong et al.Fluid flow forces and rhoA regulate fibrous development of the atrioventricular valvesDevelopmental Biology2013
Kalia, Manjula et al.Japanese Encephalitis Virus Infects Neuronal Cells through a Clathrin-Independent Endocytic MechanismJournal of Virology2013
Kanazawa, Yasushi et al.The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cellsExperimental neurology2013
Chen, Guang et al.Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells (Journal of Biological Chemistry (2012) 2Journal of Biological Chemistry2012
Greco, Carolina M. et al.Chemotactic effect of prorenin on human aortic smooth muscle cells: a novel function of the (pro)renin receptorCardiovascular Research2012
Dhaliwal, Anandika et al.Cellular Cytoskeleton Dynamics Modulates Non-Viral Gene Delivery through RhoGTPasesPLoS ONE2012
Ramsay, Alan G. et al.Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenali******: Establishing a reversible immune evasion mechanism in human cancerBlood2012
Chen, Si Meng et al.Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTORBiochemical Pharmacology2012
Howe, Grant A. et al.RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoAVascular Cell2012
Yang, Seungwon et al.The RhoA-ROCK-PTEN pathway as a molecular switch for anchorage dependent cell behaviorBiomaterials2012
Garrido‐Gómez, Tamara et al.Annexin A2 is critical for embryo adhesiveness to the human endometrium by RhoA activation through F‐actin regulationThe FASEB Journal2012
Zhou, Zhigang et al.HSV-mediated gene transfer of C3 transferase inhibits Rho to promote axonal regenerationExperimental Neurology2012
McCoy, Kelly L. et al.Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loopCellular signalling2012
Ramseyer, Vanesa D. et al.Tumor necrosis factor α decreases nitric oxide synthase type 3 expression primarily via Rho/Rho kinase in the thick ascending limbHypertension (Dallas, Tex. : 1979)2012
Jin, Wanzhu et al.Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistanceJournal of Clinical Investigation2011
Aguilar, Hector N. et al.Phos-tag-based analysis of myosin regulatory light chain phosphorylation in human uterine myocytesPLoS ONE2011
Ganguly, Riya et al.Adiponectin Increases LPL Activity via RhoA/ROCK-Mediated Actin Remodelling in Adult Rat CardiomyocytesEndocrinology2011
Musso, Alessandra et al.Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survivalHaematologica2011
Lichtenstein, Mathieu P. et al.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivativesJournal of Alzheimer's disease : JAD2010
Ridgway, Lon D. et al.Modulation of GEF-H1 Induced Signaling by Heparanase in Brain Metastatic Melanoma CellsJournal of cellular biochemistry2010
Rapier, Rebecca et al.The extracellular matrix microtopography drives critical changes in cellular motility and Rho A activity in colon cancer cellsCancer Cell International2010
Romero, Ana M. et al.Chronic ethanol exposure alters the levels, assembly, and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary cultureToxicological Sciences2010
Nini, Lylia et al.Accurate and reproducible measurements of RhoA activation in small samples of primary cellsAnalytical biochemistry2010
Yang, Enyue et al.Fluoride induces vascular contraction through activation of RhoA/Rho kinase pathway in isolated rat aortasEnvironmental toxicology and pharmacology2010
Hammar, Eva et al.Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic β-Cell FunctionEndocrinology2009
Chastre, Eric et al.TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasivenessThe FASEB Journal2009
Seifert, Jennifer L. et al.Differential activation of Rac1 and RhoA in neuroblastoma cell fractionsNeuroscience letters2009
Ramirez, Servio H. et al.Activation of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected MonocytesThe Journal of Immunology2008
Kinoshita, Nagatoki et al.Apical Accumulation of Rho in the Neural Plate Is Important for Neural Plate Cell Shape Change and Neural Tube FormationMolecular Biology of the Cell2008
Mercer, Jason et al.Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cellsScience (New York, N.Y.)2008
Sequeira, Linda et al.Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesisClinical & experimental metastasis2008
Moore, Simon W. et al.Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1Development2008
Korobova, Farida et al.Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cellsMolecular biology of the cell2008
Tanaka, Shigeru et al.Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowthThe Journal of biological chemistry2007
Schreibelt, Gerty et al.Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signalingFASEB journal2007
Keely, Patricia J. et al.Investigating integrin regulation and signaling events in three-dimensional systemsMethods in enzymology2007
AuthorTitleJournalYearArticle Link
Wang, Ting Ching et al.Genetic variation drives cancer cell adaptation to ECM stiffnessProceedings of the National Academy of Sciences2024
Wang, Hongyun et al.Klotho Stabilizes the Podocyte Actin Cytoskeleton in Idiopathic Membranous Nephropathy through Regulating the TRPC6/CatL PathwayAmerican Journal of Nephrology2024
Tokic, Silvija et al.The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial endothelial cells altered by gestational diabetes mellitusThe Journal of Physiology2024
Kim, Hugh et al.Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chainBiochemical Journal2024
Wang, Huogang et al.Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironmentExperimental Hematology & Oncology2024
Szigeti, Kinga et al.CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationeBioMedicine2024
Kumari, Reena et al.Focal adhesions contain three specialized actin nanoscale layersNature Communications 2024
Koenis, Duco Steven et al.Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of GlycolysisAdvanced Science2024
Mendoza-Soto, Pablo et al.Pharmacological Blockade of the Adenosine A2B Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of PodocytesCells2024
Vahldieck, Carl et al.Dysregulated complement activation during acute myocardial infarction leads to endothelial glycocalyx degradation and endothelial dysfunction via the C5a:C5a-Receptor1 axisFrontiers in Immunology2024
Wu, Fei et al.Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflightNature Communications2024
Lee, Choong Jae et al.The dysadherin/FAK axis promotes individual cell migration in colon cancerInternational Journal of Biological Sciences2024
Han, Xuedan et al.Increasing the tumour targeting of antitumour drugs through anlotinib-mediated modulation of the extracellular matrix and the RhoA/ROCK signalling pathwayJournal of Pharmaceutical Analysis2024
Zhang, Jiahui et al.Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoAPhytotherapy Research2024
Bock, Fabian et al.Rac1 promotes kidney collecting duct repair by mechanically coupling cell morphology to mitotic entryScience advances2024
Moztarzadeh, Sina et al.Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activationScientific Reports2024
Adhicary, Subhodip et al.Rbpj Deficiency Disrupts Vascular Remodeling via Abnormal Apelin and Cdc42 (Cell Division Cycle 42) Activity in Brain Arteriovenous MalformationStroke2023
Yue, Xianlin et al.Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescenceCell Death Discovery2023
Safavian, Darya et al.Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zoneJournal of Cell Biology2023
Xie, Wangkai et al.ASAP1 activates the IQGAP1/CDC42 pathway to promote tumor progression and chemotherapy resistance in gastric cancerCell Death & Disease2023
Huang, Xinyi et al.Actomyosin-dependent cell contractility orchestrates Zika virus infectionJournal of Cell Science2023
González, Yasmilde Rodríguez et al.PFTK1 kinase regulates axogenesis during development via RhoA activationBMC Biology2023
Ye, Qian et al.Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male miceNature Communications2023
Werder, Rhiannon B. et al.The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cellsAmerican journal of human genetics2023
Toffali, Lara et al.An isoform of the giant protein titin is a master regulator of human T lymphocyte traffickingCell reports2023
Bartos, Katalin et al.Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activityJournal of Cell Communication and Signaling2023
Escuin, Sarah et al.Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouseDMM Disease Models and Mechanisms2023
Dang, Iren et al.Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3Journal of Cell Science2023
Martínez-Rendón, Jacqueline et al.Ouabain Induces Transcript Changes and Activation of RhoA/ROCK Signaling in Cultured Epithelial Cells (MDCK)Current Issues in Molecular Biology2023
Rogg, Manuel et al.A YAP/TAZ–ARHGAP29–RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin AdhesionsCells2023
Choi, Hyehun et al.LRRC8A anion channels modulate vascular reactivity via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)FASEB journal : official publication of the Federation of American Societies for Experimental Biology2023
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