Molecular Glue Degraders: Ubiquitination Mediated Next-Generation Therapies


Targeted protein degradation is an emerging drug discovery strategy that uses small molecules to target disease-causing proteins for degradation mainly via the ubiquitin–proteasome (UPS) pathway.  The promise of these drugs over classical small molecule inhibitors is their potential to target “non-druggable” targets, overcome drug resistance, and produce a higher activity or range of action; thus, drugs that target protein degradation are emerging as novel therapeutic approaches in a wide range of diseases including inflammatory disorders, cancers, neurodegenerative diseases, and others(reviewed in 1). The two prototypical drugs that induce protein degradation include proteolysis-targeting chimera (PROTACs) and molecular glue degraders (MGDs) both of which have shown tremendous promise at targeting aberrant proteins for degradation (see Figure 1). MGDs a class of small molecules that induce, stabilize, or enhance protein-protein interactions between key regulatory proteins and ubiquitin ligases, have exploded in popularity since the identification that the immunomodulatory drug, thalidomide, functions through targeted protein degradation mechanisms2, 3. This newsletter will delve into MGDs and emerging targets and therapies.

Detect Endogenous Ubiquitination of Target Proteins


Cytoskeleton's Ubiquitin Affinity Beads (Cat. # UBA01) was used to capture endogenous Rac1 mono- and poly- Ubiquitination.  Compare how it performed versus other enrichment tools.


Your Ubiquitination Detection Kit was the best available ubiquitin enrichment tool that allowed us to effectively detect ubiquitination of our target protein +/- molecular glue

Top 10 Molecular Glue Degrader Company -- R&D Scientist

Recent Citations

Guo Q. et al. 2023. TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation Cell Reports.

Wang Y. et al. 2023. MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. Cell Discovery.

Park J. et al. 2020. Mechanical regulation of glycolysis via cytoskeleton architecture. Nature.


Cytoskeleton's Signal Seeker Ubiquitination Tools 

Ubiquitination Detection Kit (Cat. # BK161)


Ubiquitin Affinity Beads (Cat. # UBA01-Beads)


Ubiquitin Antibody (cat. # AUB01)