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Cytoskeleton Inc Signal-Seeker™ Validation Data and Citations

Signal-Seeker™ Product Citations

Ubiquitination Tools

BK161: Signal-Seeker Ubiquitination Detection Kit

AuthorTitleJournalYearArticle Link
Kholmanskikh, Stanislav et al.Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1Scientific Reports 2022 12:12022ISSN 2045--2322
Day-Walsh, Priscilla E. et al.Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory StimuliInternational Journal of Molecular Sciences2022ISSN 1422-0067
Afrin, Sadia et al.Sim******* modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradationPharmacological Research2021ISSN 1096-1186
Tumova, Lucie et al.The ubiquitin-proteasome system does not regulate the degradation of porcine β-microseminoprotein during sperm capacitationInternational Journal of Molecular Sciences2020ISSN 1422-0067
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020ISSN 1741-7007
Chu, Yi et al.O-GlcNAcylation of SIX1 enhances its stability and promotes hepatocellular carcinoma proliferationTheranostics2020ISSN 1838-7640
Uchiyama, Makoto et al.O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel ResponsesCurrent Biology2020ISSN 1879-0445
Sen, Arpita et al.The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalizationJournal of Cell Science2020ISSN 1477-9137
Park, Jin Suk et al.Mechanical regulation of glycolysis via cytoskeleton architectureNature2020ISSN 1476-4687

AUB01: Ubiquitin Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
Wang, Longlong et al.Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathwaysCell Reports2022
Martin, Thomas G. et al.Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnoverNature Communications2021ISSN 2041-1723
Manzione, Maria Giulia et al.Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cellsMolecular Biology of the Cell2020ISSN 1939-4586
Rivas, José et al.KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosisFASEB Journal2020ISSN 1530-6860
Wenzel, H. Jürgen et al.Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathologyActa neuropathologica communications2019ISSN 2051-5960
Álvarez, Alhejandra et al.KCTD5 and ubiquitin proteasome signaling are required for Helicobacter pylori adherenceFrontiers in Cellular and Infection Microbiology2017ISSN 2235-2988
Braganza, Andrea et al.UBE3B is a calmodulin-regulated, mitochondrion-associated E3 ubiquitin ligaseJournal of Biological Chemistry2017ISSN 1083-351X
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586
Hukema, Renate K. et al.Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTASHuman Molecular Genetics2015ISSN 1460-2083

AUB01-HRP: Ubiquitin-HRP Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
de Mello, Aline Haas et al.Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus InfectionAntioxidants2022ISSN 2076-3921
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586

UBA01-Beads: Ubiquitin Affinity Beads

AuthorTitleJournalYearArticle Link
Nguyen, Kha The et al.The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosisNature Cell Biology 2022ISSN 1476--4679
Dieter, Sebastian M. et al.Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancerCell Reports2021ISSN 2211-1247
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020ISSN 1741-7007
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935

CUB02-Beads: Ubiquitin Control Beads

AuthorTitleJournalYearArticle Link
Day-Walsh, Priscilla E. et al.Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory StimuliInternational Journal of Molecular Sciences2022ISSN 1422-0067
Nguyen, Kha The et al.The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosisNature Cell Biology 2022ISSN 1476--4679
Dieter, Sebastian M. et al.Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancerCell Reports2021ISSN 2211-1247
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020ISSN 1741-7007
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586

Acetyl-Lysine Tools

BK163: Signal-Seeker Acetyl-Lysine Detection Kit

AuthorTitleJournalYearArticle Link
He, Anyuan et al.Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 ActivationMolecular Cell2020ISSN 1097-4164
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020ISSN 1932-7420

AAC01: Acetyl Lysine Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
Martins, Vitor F. et al.p300 or CBP is required for insulinstimulated glucose uptake in skeletal muscle and adipocytesJCI Insight2022ISSN 2379-3708
Martins, Vitor F. et al.p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytesJCI Insight2022ISSN 2379-3708
Martins, Vitor F. et al.Germline or inducible knockout of p300 or cbp in skeletal muscle does not alter insulin sensitivityAmerican Journal of Physiology - Endocrinology and Metabolism2019ISSN 1522-1555
Sharma, Monica et al.Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancerScientific Reports2019ISSN 2045-2322
Ishihara, Akinori et al.Seasonal acclimatization and thermal acclimation induce global histone epigenetic changes in liver of bullfrog (Lithobates catesbeianus) tadpoleComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology2019ISSN 1531-4332
Yang, Youyun et al.Identification of acetylated proteins in Borrelia burgdorferiMethods in Molecular Biology2018ISSN 1064-3745
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586
LaBarge, Samuel A. et al.P300 is not required for metabolic adaptation to endurance exercise trainingFASEB Journal2016ISSN 1530-6860

AAC02: Acetyl-Lysine Antibody Mouse Monoclonal (19C4B2.1)

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

AAC03: Acetyl-Lysine Antibody Mouse Monoclonal (7B5A1)

AuthorTitleJournalYearArticle Link
Ahmed, Farjana et al.Human N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha SignalingFrontiers in Immunology2022ISSN 1664-3224
Ahmed, Farjana et al.Human N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha SignalingFrontiers in Immunology2022ISSN 1664-3224
Vega, Maria E. et al.Stimulation of Fibronectin Matrix Assembly by Lysine AcetylationCells2020ISSN 2073-4409
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020ISSN 1932-7420
Elhassan, Yasir S. et al.Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory SignaturesCell Reports2019ISSN 2211-1247
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

AAC03-HRP: Acetyl-Lysine-HRP Antibody Mouse Monoclonal (7B5A1)

AuthorTitleJournalYearArticle Link
Vega, Maria E. et al.Stimulation of Fibronectin Matrix Assembly by Lysine AcetylationCells2020ISSN 2073-4409
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020ISSN 1932-7420

AAC04-Beads: Acetyl-Lysine Affinity Beads

AuthorTitleJournalYearArticle Link
He, Ying et al.PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic RhythmsAdvanced Science2023ISSN 2198--3844
Kumar, Manish et al.Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of functionNature Communications2021ISSN 2041-1723
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

CIG02-Beads: Acetyl-Lysine Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

AACX1: Chemically Acetylated Bovine Serum Albumin (BSA)

AACX2: Tricostatin A (TSA) treated and untreated cell lysates

SUMOylation 2/3 Tools

BK162: Signal-Seeker SUMOylation 2/3 Detection Kit

AuthorTitleJournalYearArticle Link
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X

ASM23: SUMO-2/3 Antibody Mouse Monoclonal (Clone 12F3)

AuthorTitleJournalYearArticle Link
Zhao, Rongwei et al.Chemical dimerization-induced protein condensates on telomeresJournal of Visualized Experiments2021ISSN 1940-087X
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X
Pronot, Marie et al.Proteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat BrainFrontiers in Molecular Neuroscience2021ISSN 1662-5099
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020ISSN 2059-3635
Yan, Yao Long et al.DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional programPLoS Biology2019ISSN 1545-7885

ASM23-HRP: SUMO-2/3-HRP Antibody Monoclonal (Clone 12F3)

AuthorTitleJournalYearArticle Link
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020ISSN 2059-3635

ASM24: SUMO-2/3 Antibody Mouse Monoclonal (Clone 11G2)

AuthorTitleJournalYearArticle Link
Colussi, Claudia et al.Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's diseaseNeuropathology and Applied Neurobiology2023ISSN 1365--2990
Waters, Emily et al.The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1EMBO reports2022ISSN 1469--3178

ASM24-Beads: SUMOylation 2/3 Affinity Beads

AuthorTitleJournalYearArticle Link
Waters, Emily et al.The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1EMBO reports2022ISSN 1469--221X
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020ISSN 2059-3635
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586

CIG01-Beads: IgG Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

SUMOylation 1 Tools

BK165: Signal-Seeker SUMOylation 1 Detection Kit

ASM01: SUMO1 Antibody Mouse Monoclonal (Clone 5D8B16)

AuthorTitleJournalYearArticle Link
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021ISSN 1879-260X

ASM11-Beads: SUMOylation 1 Affinity Beads

CIG03-Beads: SUMO1 IP Control Beads

Phosphotyrosine Tools

BK160: Signal-Seeker Phosphotyrosine Detection Kit

APY03: Phosphotyrosine Antibody Mouse Monoclonal (27B10)

AuthorTitleJournalYearArticle Link
Ahler, Ethan et al.A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent FunctionsMolecular Cell2019ISSN 1097-4164
Kline, Ashley et al.The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamberDevelopmental Biology2018ISSN 1095-564X
Seki, Takahiro et al.Ablation of endothelial VEG FR1 improves metabolic dysfunction by inducing adipose tissue browningJournal of Experimental Medicine2018ISSN 1540-9538
Cheng, Larry C. et al.Phosphopeptide enrichment coupled with label-free quantitative mass spectrometry to investigate the phosphoproteome in prostate cancerJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017ISSN 1476-5586
Kaukonen, Riina et al.Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcriptionNature Communications2016ISSN 2041-1723

APY03-HRP: Phosphotyrosine-HRP Mouse Monclonal Antibody (27B10)

APY03-Beads: Phosphotyrosine Affinity Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Cheng, Larry C. et al.Phosphopeptide enrichment coupled with label-free quantitative mass spectrometry to investigate the phosphoproteome in prostate cancerJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017ISSN 1573-4935
Kaukonen, Riina et al.Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcriptionNature Communications2016ISSN 2041-1723

CIG01-Beads: IgG Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018ISSN 2227-7382

Actin Oxidation Tools

MXA95: MICAL-Oxidized Action Protein

MPAX1: MICAL-Oxidized (Pyrene Labeled) Actin Protein

MIC01: MICAL-1 Protein 6xHis

MB201: MsrB2 Protein 6xHis

BlastR Filter System Tools

BLR01: BlastR Rapid Lysate Prep Kit

BLR02: BlastR Rapid Flitration Kit

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018ISSN 1940-087X

BLR03: BlastR Lysis/Dilution Buffer Kit

AuthorTitleJournalYearArticle Link
D'Amico, Gabriela et al.ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterningDevelopment (Cambridge, England)2022ISSN 1477-9129
Signal-Seeker™ Info
Signal-Seeker™ Info Resources
Technical Support

Acetylation Data:

Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 – Signal Seeker BK163 Kit & Acetyl-Lysine Affinity Beads AAC04-BEADS Application = IP /  Acetyl-Lysine-HRP Antibody Mouse Monoclonal  AAC03-HRP Application = WB

He A. et al. 2020. Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Mol Cell. 2020 Jul 2;79(1):30-42.e4. doi: 10.1016/j.molcel.2020.05.007. Epub 2020 May 29. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Losson H. et al. 2020. The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia. Pharmacol Res. 2020 Jun 30;105058. doi: 10.1016/j.phrs.2020.105058. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Aon M. et al. 2020. Untangling Determinants of Enhanced Health and Lifespan Through a Multi-omics Approach in Mice. Cell Metab. 2020 May 11;S1550-4131(20)30235-7. doi: 10.1016/j.cmet.2020.04.018. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Vega M. et al. 2020. Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation. Cells. 2020 Mar 8;9(3):655. doi: 10.3390/cells9030655. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Elhassan Y. et al. 2019. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. -- Anti-Acetyl-Lysine Monoclonal: (AAC03) -- Application: WB

Sharma M. et al. 2019. Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer. Sci Rep. 2019 Nov 7;9(1):16257. doi: 10.1038/s41598-019-52723-3. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP

Martins V. et al. 2019. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1024-E1035. doi: 10.1152/ajpendo.00497.2018. Epub 2019 Mar 19. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP

Ishihara A. et al. 2019. Seasonal acclimatization and thermal acclimation induce global histone epigenetic changes in liver of bullfrog (Lithobates catesbeianus) tadpole. Comp Biochem Physiol A Mol Integr Physiol. doi: 10.1016/j.cbpa.2018.12.014. -- Anti-Acetyl Lysine Monoclonal: (AAC01-S) --Application:

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP; Anti-Acetyl Lysine Monoclonal: (AAC02) --Application: IF

Yang Y. et al. 2018. Identification of Acetylated Proteins in Borrelia burgdorferi. Methods Mol Biol. 2018;1690:177-182. doi: 10.1007/978-1-4939-7383-5_14. -- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IP

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

LaBarge S.A. et al. 2016. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. Doi: 10.1096/fj.15-281741.-- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IF

ASCB 2017 Poster: Tracking changes in mitochondrial acetylation by immunofluorescence provides new insight into HDACs class I/II and class III crosstalk -- Anti-Acetyl-Lysine Monoclonal: (AAC02), Signal-Seeker™ kit BK163 (Ac)

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

Acetyl Lysine White Paper: Utilization of newly developed mouse monoclonal anti-acetyl lysine antibodies in western blot and immunoprecipitation applications

Anti-Acetyl Lysine Mitochondrial Protein Immunofluorescence White Paper

Sumolaytion 2/3 Validation Data: 

Andreev V. et al. 2022. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Nat Struct Mol Biol. 2022 Feb;29(2):130-142. doi: 10.1038/s41594-022-00721-x. Epub 2022 Feb 16. – anti SUMOylation 2/3 monoclonal: (ASM23) – Application: WB

Zhang H. et al. 2020. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020 Jun 24;mbcE19100589. doi: 10.1091/mbc.E19-10-0589. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: IF

Zhou L. et al. 2020. SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Signal Transduct Target Ther. 2020 Jun 24;5(1):80. doi: 10.1038/s41392-020-0172-4. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: WB

Yan Y. et al. 2019. DPPA2/4 and SUMO E3 Ligase PIAS4 Opposingly Regulate Zygotic Transcriptional Program. PLoS Biol. 2019 Jun 21;17(6):e3000324. doi: 10.1371/journal.pbio.3000324. eCollection 2019 Jun. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: PLA

Dubuisson L. et al. 2018. Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner. Oncogene. doi: 10.1038/s41388-018-0163-x. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Kaci A. et al. 2018. The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α. Sci Rep. doi: 10.1038/s41598-018-29448-w. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

SUMOylation 2/3 White Paper: Validation of SUMO-2/3 Antibodies (12F3 and 11G2) in Western Blot, Immunoprecipitation and Immunofluorescence Applications  

SUMO 2/3 White Paper: Tips for utilizing SUMO 2/3 Detection Reagents and Kits to identify endogenous SUMOylation 2/3 modified target proteins in cells and tissue

Tyrosine Phosphorylation Data:

Ahler E. et al. 2019. A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Mol Cell. 2019 Apr 18;74(2):393-408.e20. doi: 10.1016/j.molcel.2019.02.003. Epub 2019 Apr 4. -- Anti-Phosphotyrosine Monoclonal: (APY03) -- Application: WB

Landeck N. et al. 2019. Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein. Biorxiv. https://doi.org/10.1101/700377. -- Anti-Phosphotyrosine Monoclonal: (APY03-HRP) -- Application: WB

Seki T. et al. 2018. Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning. J Exp Med. doi: 10.1084/jem.20171012. -- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Kline A. et al. 2018. The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber. Dev Biol. pii: S0012-1606(18)30067-8. doi: 10.1016/j.ydbio.2018.05.006. -- Anti-Phosphotyrosine Monoclonal: (APY03)

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Yusuf M.Z. et al. 2017. Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability. Sci Rep. Doi: 10.1038/s41598-017-05817-9.-- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IF

Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Kaukonen R. et al. 2016. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. Doi: 10.1038/ncomms12237.-- Anti-Phosphotyrosine Monoclonal: (APY03), Phosphotyrosine Affinity Beads (APY03-Beads) --Application: WB, IP

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

ASCB 2015 Poster: Temporal regulation of phosphotyrosine-modified Rac1 in response to epidermal growth factor stimulation -- Signal-Seeker™ kit: BK160 (pY)

Phosphotyrosine White Paper: Comparison of Phosphotyrosine Antibodies 27B10.4 and 4G10 in Immunoprecipitation, Immunofluorescence and Western Blot Applications

Ubiquitination Validation Data:

Martin, T.G., Myers, V.D., Dubey, P. et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun 12, 2942 (2021). https://doi.org/10.1038/s41467-021-23272-z -  -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF

Sebastian M. Dieter, et al., Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer, Cell Reports, Volume 36, Issue 3, 2021, 109394, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2021.109394.

Uchiyama M. et al. 2020. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. Current Biology. 2020 Sep 7;30(17):3378-3396.e7. doi: 10.1016/j.cub.2020.06.047. Epub 2020 Jul 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Sen A. et al. 2020. The Na + pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization. J Cell Sci. 2020 Aug 21;133(16):jcs245415. doi: 10.1242/jcs.245415. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Park J. et al. 2020. Mechanical Regulation of Glycolysis via Cytoskeleton Architecture. Nature. 2020 Feb;578(7796):621-626. doi: 10.1038/s41586-020-1998-1. Epub 2020 Feb 12. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Tumova L. et al. 2020. The Ubiquitin-Proteasome System Does Not Regulate the Degradation of Porcine β-Microseminoprotein during Sperm Capacitation. Int J Mol Sci. 2020 Jun 10;21(11):4151. doi: 10.3390/ijms21114151. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Frindt G. et al. 2020. Ubiquitination of Renal ENaC Subunits in Vivo. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1113-F1121. doi: 10.1152/ajprenal.00609.2019. Epub 2020 Mar 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Gu C. et al. 2020. Identification of Berberine as a Novel Drug for the Treatment of Multiple Myeloma via Targeting UHRF1. BMC Biol. 2020 Mar 25;18(1):33. doi: 10.1186/s12915-020-00766-8. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Manzione M. et al. 2020. Co-regulation of the Antagonistic RepoMan:Aurora-B Pair in Proliferating Cells. Mol Biol Cell. 2020 Mar 15;31(6):419-438. doi: 10.1091/mbc.E19-12-0698. Epub 2020 Jan 22. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Rivas J. et al. 2020. KCTD5, a Novel TRPM4-regulatory Protein Required for Cell Migration as a New Predictor for Breast Cancer Prognosis. Am J Physiol Renal Physiol. FASEB J. 2020 Apr 17. doi: 10.1096/fj.201901195RRR. Online ahead of print. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Wenzel HJ. et al. 2019. Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathol Commun. doi: 10.1186/s40478-019-0677-7. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF

Brophy M. et al. 2019. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res. doi: 10.1161/CIRCRESAHA.118.313028. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Martini V. et al. 2018. Abnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia. Oncotarget. doi: 10.18632/oncotarget.25951. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP

Alvarez A. et al. 2017. KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Front Cell Infect Microbiol. 2017 Oct 24;7:450. doi: 10.3389/fcimb.2017.00450. -- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Braganza A. et al. 2017. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. Doi: 10.1074/jbc.M116.766824.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK161--Application: IP

Rahman H.N.A. et al. Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Cir Res. Doi: 10.1161/CIRCRESAHA.115.307679.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Hukema R.K. et al. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. Doi: 10.1093/hmg/ddv216.-- Anti-Ubiquitin Monoclonal: (AUB01-S) --Application: IF

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

Ubiquitination White Paper -- Signal-Seeker™ kits: BK161 (Ub), Ubiquitination affinity beads (UBA01-beads), Ubiquitination control beads (CUB02), HRP-Anti-Ubiquitin Monoclonal: AUB01-HRP

Blaster Validation Data:

Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 BlastR Rapid Lysate Prep Kit BLR01, BlastR Rapid Filtration Kit BLR02, BlastR™ Lysis/Dilution Buffer Kit BLR03

Tanimoto, A. et al. Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression doi: 10.1158/1078-0432.CCR-20-2853 BlastR Rapid Lysate Prep Kit BLR01

Horita H. et al. 2018. Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins. J. Vis. Exp. (131), e56912, doi:10.3791/56912. -- Signal-Seeker™ kits

ASCB 2016 Poster: Complete removal of genomic DNA from cell lysate enhances the quality of protein research -- BlastR™ Filter (BLR02)

BlastR™ Buffer Comparison with conventional lysis buffers -- BlastR™ Rapid Lysate Prep kit (BLR01, BLR02)

PTM crosstalk:

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kits

Horita H. et al. 2018. Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins. J. Vis. Exp. (131), e56912, doi:10.3791/56912. -- Signal-Seeker™ kits

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3), BK163 (Ac)

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

cJUN White Paper -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)