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Cytoskeleton Inc Signal-Seeker™ Validation Data and Citations

Signal-Seeker™ Product Citations

Ubiquitination Tools

BK161: Signal-Seeker Ubiquitination Detection Kit

AuthorTitleJournalYearArticle Link
Otani, Takahito et al.The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research2024
Ruggeri, Edoardo et al.Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapyFrontiers in Immunology2024
Shi, Shujie et al.Control of ENaC ubiquitinationRenal Physiology2024
Kotani, Hiroshi et al.Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damageJournal of Biomedical Science2024
Hołda, Mateusz K. et al.Autophagy and ubiquitin-dependent proteolysis processes in left ventricular mass loss in pulmonary arterial hypertensionScientific Reports2024
Liu, Shiwei et al.O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear ExportInternational Journal of Biological Sciences2024
Yu, Hui et al.MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2Journal of Cellular and Molecular Medicine2024
Steinbach, Adriana et al.Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophilaMolecular biology of the cell2024
Hotani, Takuma et al.Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1αInflammation2023
Chen, Shanlin et al.Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cellsPhytotherapy Research2023
Guo, Qianjin et al.TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradationCell reports2023
Huang, Xiaogang et al.Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2BOpen Medicine2023
Tahaei, Ebrahim et al.Pendrin regulation is prioritized by anion in high-potassium dietsAmerican Journal of Physiology - Renal Physiology2023
Wang, Yuan et al.MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradationCell Discovery 2023
Román-Fernández, Alvaro et al.Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic functionScience Advances2023
Yang Z. et. al.Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired ResistanceCancer Discov2022
Kholmanskikh, Stanislav et al.Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1Scientific Reports 2022 12:12022
Day-Walsh, Priscilla E. et al.Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory StimuliInternational Journal of Molecular Sciences2022
Afrin, Sadia et al.Sim******* modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradationPharmacological Research2021
Tumova, Lucie et al.The ubiquitin-proteasome system does not regulate the degradation of porcine β-microseminoprotein during sperm capacitationInternational Journal of Molecular Sciences2020
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020
Chu, Yi et al.O-GlcNAcylation of SIX1 enhances its stability and promotes hepatocellular carcinoma proliferationTheranostics2020
Uchiyama, Makoto et al.O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel ResponsesCurrent Biology2020
Sen, Arpita et al.The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalizationJournal of Cell Science2020
Park, Jin Suk et al.Mechanical regulation of glycolysis via cytoskeleton architectureNature2020

AUB01: Ubiquitin Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
Plooy, Lukas M. du et al.A fungal ubiquitin ligase and arrestin binding partner contribute to pathogenesis and survival during cellular stressmBio2024
Pino-Belmar, Camila et al.An Intrinsic Host Defense against HSV-1 Relies on the Activation of Xenophagy with the Active Clearance of Autophagic ReceptorsCells 2024
Takeda, Kenji et al.A Novel Approach: Investigating the Intracellular Clearance Mechanism of Glyceraldehyde-Derived Advanced Glycation End-Products Using the Artificial Checkpoint Kinase 1 d270KD Mutant as a Substrate ModelCells2023
Martin, Thomas G. et al.Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co-Occurrence of P63A and P380S BAG3 VariantsJournal of the American Heart Association2023
Wang, Longlong et al.Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathwaysCell Reports2022
Martin, Thomas G. et al.Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnoverNature Communications2021
Manzione, Maria Giulia et al.Co-regulation of the antagonistic RepoMan:Aurora-B pair in proliferating cellsMolecular Biology of the Cell2020
Rivas, José et al.KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosisFASEB Journal2020
Wenzel, H. Jürgen et al.Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathologyActa neuropathologica communications2019
Álvarez, Alhejandra et al.KCTD5 and ubiquitin proteasome signaling are required for Helicobacter pylori adherenceFrontiers in Cellular and Infection Microbiology2017
Braganza, Andrea et al.UBE3B is a calmodulin-regulated, mitochondrion-associated E3 ubiquitin ligaseJournal of Biological Chemistry2017
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017
Hukema, Renate K. et al.Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTASHuman Molecular Genetics2015

AUB01-HRP: Ubiquitin-HRP Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
Liu, Fan et al.BAK1 protects the receptor-like kinase BIR2 from SNIPER2a/b-mediated degradation to promote pattern-triggered immunity in Nicotiana benthamianaThe Plant Cell2023
de Mello, Aline Haas et al.Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus InfectionAntioxidants2022
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017

UBA01-Beads: Ubiquitin Affinity Beads

AuthorTitleJournalYearArticle Link
Otani, Takahito et al.The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research2024
Ruggeri, Edoardo et al.Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapyFrontiers in Immunology2024
Shi, Shujie et al.Control of ENaC ubiquitinationRenal Physiology2024
Kotani, Hiroshi et al.Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damageJournal of Biomedical Science2024
Hołda, Mateusz K. et al.Autophagy and ubiquitin-dependent proteolysis processes in left ventricular mass loss in pulmonary arterial hypertensionScientific Reports2024
Liu, Shiwei et al.O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear ExportInternational Journal of Biological Sciences2024
Yu, Hui et al.MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2Journal of Cellular and Molecular Medicine2024
Steinbach, Adriana et al.Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophilaMolecular biology of the cell2024
Hotani, Takuma et al.Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1αInflammation2023
Chen, Shanlin et al.Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cellsPhytotherapy Research2023
Guo, Qianjin et al.TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradationCell reports2023
Huang, Xiaogang et al.Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2BOpen Medicine2023
Tahaei, Ebrahim et al.Pendrin regulation is prioritized by anion in high-potassium dietsAmerican Journal of Physiology - Renal Physiology2023
Wang, Yuan et al.MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradationCell Discovery 2023
Román-Fernández, Alvaro et al.Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic functionScience Advances2023
Nguyen, Kha The et al.The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosisNature Cell Biology 2022
Dieter, Sebastian M. et al.Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancerCell Reports2021
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017

CUB02-Beads: Ubiquitin Control Beads

AuthorTitleJournalYearArticle Link
Otani, Takahito et al.The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research2024
Hotani, Takuma et al.Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1αInflammation2023
Chen, Shanlin et al.Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cellsPhytotherapy Research2023
Day-Walsh, Priscilla E. et al.Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory StimuliInternational Journal of Molecular Sciences2022
Nguyen, Kha The et al.The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosisNature Cell Biology 2022
Dieter, Sebastian M. et al.Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancerCell Reports2021
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017

Acetyl-Lysine Tools

BK163: Signal-Seeker Acetyl-Lysine Detection Kit

AuthorTitleJournalYearArticle Link
Williams D. et. al.Type II Interleukin-4 Receptor Activation in Basal Breast Cancer Cells Promotes Tumor Progression via Metabolic and Epigenetic ModulationIntl Jrnl of Mol Sci2024
Yonezawa, Taishi et al.The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1-dependent leukemia cellsThe FEBS Journal2023
Adhikari, Raghabendra et al.Alcohol-induced tubulin post-translational modifications directly alter hepatic protein traffickingHepatology Communications2023
He, Ying et al.PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic RhythmsAdvanced Science2023
Oldfield C. et. al.Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activityPhysiol Rep.2021
Kumar, Manish et al.Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of functionNature Communications2021
Losson H. et. al.The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imat**** to trigger apoptosis in chronic myeloid leukemiaPharmacol Res.2020
Vega M. et. al.Stimulation of Fibronectin Matrix Assembly by Lysine AcetylationCells2020
He, Anyuan et al.Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 ActivationMolecular Cell2020
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

AAC01: Acetyl Lysine Antibody Mouse Monoclonal

AuthorTitleJournalYearArticle Link
Son, Sung Min et al.p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndromeNature Cell Biology 2024 26:22024
Martins, Vitor F. et al.p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytesJCI Insight2022
Martins, Vitor F. et al.p300 or CBP is required for insulinstimulated glucose uptake in skeletal muscle and adipocytesJCI Insight2022
Martins, Vitor F. et al.Germline or inducible knockout of p300 or cbp in skeletal muscle does not alter insulin sensitivityAmerican Journal of Physiology - Endocrinology and Metabolism2019
Sharma, Monica et al.Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancerScientific Reports2019
Ishihara, Akinori et al.Seasonal acclimatization and thermal acclimation induce global histone epigenetic changes in liver of bullfrog (Lithobates catesbeianus) tadpoleComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology2019
Yang, Youyun et al.Identification of acetylated proteins in Borrelia burgdorferiMethods in Molecular Biology2018
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017
LaBarge, Samuel A. et al.P300 is not required for metabolic adaptation to endurance exercise trainingFASEB Journal2016

AAC02: Acetyl-Lysine Antibody Mouse Monoclonal (19C4B2.1)

AuthorTitleJournalYearArticle Link
Yasuda, Tatsuki et al.Mitochondrial dynamics define muscle fiber type by modulating cellular metabolic pathwaysCell Reports2023
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

AAC03: Acetyl-Lysine Antibody Mouse Monoclonal (7B5A1)

AuthorTitleJournalYearArticle Link
Ahmed, Farjana et al.Human N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha SignalingFrontiers in Immunology2022
Ahmed, Farjana et al.Human N-Alpha-Acetyltransferase 60 Promotes Influenza A Virus Infection by Dampening the Interferon Alpha SignalingFrontiers in Immunology2022
Vega, Maria E. et al.Stimulation of Fibronectin Matrix Assembly by Lysine AcetylationCells2020
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020
Elhassan, Yasir S. et al.Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory SignaturesCell Reports2019
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

AAC03-HRP: Acetyl-Lysine-HRP Antibody Mouse Monoclonal (7B5A1)

AuthorTitleJournalYearArticle Link
Vega, Maria E. et al.Stimulation of Fibronectin Matrix Assembly by Lysine AcetylationCells2020
Aon, Miguel A. et al.Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in MiceCell Metabolism2020

AAC04-Beads: Acetyl-Lysine Affinity Beads

AuthorTitleJournalYearArticle Link
He, Ying et al.PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic RhythmsAdvanced Science2023
Oldfield C. et. al.Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activityPhysiol Rep.2021
Kumar, Manish et al.Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of functionNature Communications2021
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

CIG02-Beads: Acetyl-Lysine Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

AACX1: Chemically Acetylated Bovine Serum Albumin (BSA)

AACX2: Tricostatin A (TSA) treated and untreated cell lysates

SUMOylation 2/3 Tools

BK162: Signal-Seeker SUMOylation 2/3 Detection Kit

AuthorTitleJournalYearArticle Link
Nguyen, Minh T.H. et al.Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transitionFrontiers in Cardiovascular Medicine2023
Yan CH. et. al.AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120Nat Commun2022
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021

ASM23: SUMO-2/3 Antibody Mouse Monoclonal (Clone 12F3)

AuthorTitleJournalYearArticle Link
Garvin, Alexander J. et al.SUMO monoclonal antibodies vary in sensitivity, specificity, and ability to detect types of SUMO conjugateScientific Reports2022
Zhao, Rongwei et al.Chemical dimerization-induced protein condensates on telomeresJournal of Visualized Experiments2021
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021
Pronot, Marie et al.Proteomic Identification of an Endogenous Synaptic SUMOylome in the Developing Rat BrainFrontiers in Molecular Neuroscience2021
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020
Yan, Yao Long et al.DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional programPLoS Biology2019

ASM23-HRP: SUMO-2/3-HRP Antibody Monoclonal (Clone 12F3)

AuthorTitleJournalYearArticle Link
Juncker, Meredith et al.ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in Ataxia Telangiectasia cellsBiochimica et Biophysica Acta - Molecular Basis of Disease2021
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020

ASM24: SUMO-2/3 Antibody Mouse Monoclonal (Clone 11G2)

AuthorTitleJournalYearArticle Link
Colussi, Claudia et al.Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg mouse model of Alzheimer's diseaseNeuropathology and Applied Neurobiology2023

ASM24-Beads: SUMOylation 2/3 Affinity Beads

AuthorTitleJournalYearArticle Link
Waters, Emily et al.The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1EMBO reports2022
Zhou, Liwen et al.SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sitesSignal Transduction and Targeted Therapy2020
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017

CIG01-Beads: IgG Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

SUMOylation 1 Tools

BK165: Signal-Seeker SUMOylation 1 Detection Kit

ASM01: SUMO1 Antibody Mouse Monoclonal (Clone 5D8B16)

AuthorTitleJournalYearArticle Link
Kim, Catherine et al.SUMOylation of mitofusins: A potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressorsBiochimica et Biophysica Acta - Molecular Basis of Disease2021

ASM11-Beads: SUMOylation 1 Affinity Beads

CIG03-Beads: SUMO1 IP Control Beads

Phosphotyrosine Tools

BK160: Signal-Seeker Phosphotyrosine Detection Kit

APY03: Phosphotyrosine Antibody Mouse Monoclonal (27B10)

AuthorTitleJournalYearArticle Link
Ahler, Ethan et al.A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent FunctionsMolecular Cell2019
Kline, Ashley et al.The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamberDevelopmental Biology2018
Seki, Takahiro et al.Ablation of endothelial VEG FR1 improves metabolic dysfunction by inducing adipose tissue browningJournal of Experimental Medicine2018
Cheng, Larry C. et al.Phosphopeptide enrichment coupled with label-free quantitative mass spectrometry to investigate the phosphoproteome in prostate cancerJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017
Horita, Henrick et al.Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on MonoubiquitinatonNeoplasia (United States)2017
Kaukonen, Riina et al.Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcriptionNature Communications2016

APY03-HRP: Phosphotyrosine-HRP Mouse Monclonal Antibody (27B10)

APY03-Beads: Phosphotyrosine Affinity Beads

AuthorTitleJournalYearArticle Link
Cheng, Larry C. et al.Phosphopeptide enrichment coupled with label-free quantitative mass spectrometry to investigate the phosphoproteome in prostate cancerJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018
Horita, Henrick et al.A simple toolset to identify endogenous post-translational modifications for a target protein: A snapshot of the EGFR signaling pathwayBioscience Reports2017
Kaukonen, Riina et al.Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcriptionNature Communications2016

CIG01-Beads: IgG Control Beads

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018
Horita, Henrick et al.Utilizing optimized tools to investigate PTM crosstalk: Identifying potential PTM crosstalk of acetylated mitochondrial proteinsProteomes2018

Actin Oxidation Tools

MXA95: MICAL-Oxidized Action Protein

MPAX1: MICAL-Oxidized (Pyrene Labeled) Actin Protein

MIC01: MICAL-1 Protein 6xHis

AuthorTitleJournalYearArticle Link
Martin, Jose L. et al.Actin Isoform Composition and Binding Factors Fine-Tune Regulatory Impact of Mical EnzymesInternational Journal of Molecular Sciences2023

MB201: MsrB2 Protein 6xHis

BlastR Filter System Tools

BLR01: BlastR Rapid Lysate Prep Kit

BLR02: BlastR Rapid Flitration Kit

AuthorTitleJournalYearArticle Link
Horita, Henrick et al.Utilizing a comprehensive immunoprecipitation enrichment system to identify an endogenous post-translational modification profile for target proteinsJournal of Visualized Experiments2018

BLR03: BlastR Lysis/Dilution Buffer Kit

AuthorTitleJournalYearArticle Link
D'Amico, Gabriela et al.ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterningDevelopment (Cambridge, England)2022
Signal-Seeker™ Info
Signal-Seeker™ Info Resources
Technical Support

Acetylation Data:

Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 – Signal Seeker BK163 Kit & Acetyl-Lysine Affinity Beads AAC04-BEADS Application = IP /  Acetyl-Lysine-HRP Antibody Mouse Monoclonal  AAC03-HRP Application = WB

He A. et al. 2020. Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation. Mol Cell. 2020 Jul 2;79(1):30-42.e4. doi: 10.1016/j.molcel.2020.05.007. Epub 2020 May 29. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Losson H. et al. 2020. The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia. Pharmacol Res. 2020 Jun 30;105058. doi: 10.1016/j.phrs.2020.105058. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Aon M. et al. 2020. Untangling Determinants of Enhanced Health and Lifespan Through a Multi-omics Approach in Mice. Cell Metab. 2020 May 11;S1550-4131(20)30235-7. doi: 10.1016/j.cmet.2020.04.018. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Vega M. et al. 2020. Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation. Cells. 2020 Mar 8;9(3):655. doi: 10.3390/cells9030655. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

Elhassan Y. et al. 2019. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. -- Anti-Acetyl-Lysine Monoclonal: (AAC03) -- Application: WB

Sharma M. et al. 2019. Acetylation of conserved DVL-1 lysines regulates its nuclear translocation and binding to gene promoters in triple-negative breast cancer. Sci Rep. 2019 Nov 7;9(1):16257. doi: 10.1038/s41598-019-52723-3. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP

Martins V. et al. 2019. Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1024-E1035. doi: 10.1152/ajpendo.00497.2018. Epub 2019 Mar 19. -- Anti-Acetyl-Lysine Monoclonal: (AAC01) -- Application: IP

Ishihara A. et al. 2019. Seasonal acclimatization and thermal acclimation induce global histone epigenetic changes in liver of bullfrog (Lithobates catesbeianus) tadpole. Comp Biochem Physiol A Mol Integr Physiol. doi: 10.1016/j.cbpa.2018.12.014. -- Anti-Acetyl Lysine Monoclonal: (AAC01-S) --Application:

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP; Anti-Acetyl Lysine Monoclonal: (AAC02) --Application: IF

Yang Y. et al. 2018. Identification of Acetylated Proteins in Borrelia burgdorferi. Methods Mol Biol. 2018;1690:177-182. doi: 10.1007/978-1-4939-7383-5_14. -- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IP

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK163 (Ac) --Application: IP

LaBarge S.A. et al. 2016. p300 is not required for metabolic adaptation to endurance exercise training. FASEB J. Doi: 10.1096/fj.15-281741.-- Anti-Acetyl Lysine Monoclonal: (AAC01) --Application: IF

ASCB 2017 Poster: Tracking changes in mitochondrial acetylation by immunofluorescence provides new insight into HDACs class I/II and class III crosstalk -- Anti-Acetyl-Lysine Monoclonal: (AAC02), Signal-Seeker™ kit BK163 (Ac)

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

Acetyl Lysine White Paper: Utilization of newly developed mouse monoclonal anti-acetyl lysine antibodies in western blot and immunoprecipitation applications

Anti-Acetyl Lysine Mitochondrial Protein Immunofluorescence White Paper

Sumolaytion 2/3 Validation Data: 

Andreev V. et al. 2022. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Nat Struct Mol Biol. 2022 Feb;29(2):130-142. doi: 10.1038/s41594-022-00721-x. Epub 2022 Feb 16. – anti SUMOylation 2/3 monoclonal: (ASM23) – Application: WB

Zhang H. et al. 2020. Nuclear body phase separation drives telomere clustering in ALT cancer cells. Mol Biol Cell. 2020 Jun 24;mbcE19100589. doi: 10.1091/mbc.E19-10-0589. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: IF

Zhou L. et al. 2020. SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites. Signal Transduct Target Ther. 2020 Jun 24;5(1):80. doi: 10.1038/s41392-020-0172-4. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: WB

Yan Y. et al. 2019. DPPA2/4 and SUMO E3 Ligase PIAS4 Opposingly Regulate Zygotic Transcriptional Program. PLoS Biol. 2019 Jun 21;17(6):e3000324. doi: 10.1371/journal.pbio.3000324. eCollection 2019 Jun. -- Anti-SUMO 2/3 Monoclonal: (ASM23) -- Application: PLA

Dubuisson L. et al. 2018. Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner. Oncogene. doi: 10.1038/s41388-018-0163-x. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Kaci A. et al. 2018. The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α. Sci Rep. doi: 10.1038/s41598-018-29448-w. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK162 (SUMO 2/3) --Application: IP

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

SUMOylation 2/3 White Paper: Validation of SUMO-2/3 Antibodies (12F3 and 11G2) in Western Blot, Immunoprecipitation and Immunofluorescence Applications  

SUMO 2/3 White Paper: Tips for utilizing SUMO 2/3 Detection Reagents and Kits to identify endogenous SUMOylation 2/3 modified target proteins in cells and tissue

Tyrosine Phosphorylation Data:

Ahler E. et al. 2019. A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions. Mol Cell. 2019 Apr 18;74(2):393-408.e20. doi: 10.1016/j.molcel.2019.02.003. Epub 2019 Apr 4. -- Anti-Phosphotyrosine Monoclonal: (APY03) -- Application: WB

Landeck N. et al. 2019. Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein. Biorxiv. https://doi.org/10.1101/700377. -- Anti-Phosphotyrosine Monoclonal: (APY03-HRP) -- Application: WB

Seki T. et al. 2018. Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning. J Exp Med. doi: 10.1084/jem.20171012. -- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Kline A. et al. 2018. The Misshapen kinase regulates the size and stability of the germline ring canals in the Drosophila egg chamber. Dev Biol. pii: S0012-1606(18)30067-8. doi: 10.1016/j.ydbio.2018.05.006. -- Anti-Phosphotyrosine Monoclonal: (APY03)

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Yusuf M.Z. et al. 2017. Prostacyclin reverses platelet stress fibre formation causing platelet aggregate instability. Sci Rep. Doi: 10.1038/s41598-017-05817-9.-- Anti-Phosphotyrosine Monoclonal: (APY03) --Application: IF

Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK160 (pY) --Application: IP

Kaukonen R. et al. 2016. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. Doi: 10.1038/ncomms12237.-- Anti-Phosphotyrosine Monoclonal: (APY03), Phosphotyrosine Affinity Beads (APY03-Beads) --Application: WB, IP

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

ASCB 2015 Poster: Temporal regulation of phosphotyrosine-modified Rac1 in response to epidermal growth factor stimulation -- Signal-Seeker™ kit: BK160 (pY)

Phosphotyrosine White Paper: Comparison of Phosphotyrosine Antibodies 27B10.4 and 4G10 in Immunoprecipitation, Immunofluorescence and Western Blot Applications

Ubiquitination Validation Data:

Martin, T.G., Myers, V.D., Dubey, P. et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun 12, 2942 (2021). https://doi.org/10.1038/s41467-021-23272-z -  -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF

Sebastian M. Dieter, et al., Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer, Cell Reports, Volume 36, Issue 3, 2021, 109394, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2021.109394.

Uchiyama M. et al. 2020. O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses. Current Biology. 2020 Sep 7;30(17):3378-3396.e7. doi: 10.1016/j.cub.2020.06.047. Epub 2020 Jul 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Sen A. et al. 2020. The Na + pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization. J Cell Sci. 2020 Aug 21;133(16):jcs245415. doi: 10.1242/jcs.245415. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Park J. et al. 2020. Mechanical Regulation of Glycolysis via Cytoskeleton Architecture. Nature. 2020 Feb;578(7796):621-626. doi: 10.1038/s41586-020-1998-1. Epub 2020 Feb 12. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Tumova L. et al. 2020. The Ubiquitin-Proteasome System Does Not Regulate the Degradation of Porcine β-Microseminoprotein during Sperm Capacitation. Int J Mol Sci. 2020 Jun 10;21(11):4151. doi: 10.3390/ijms21114151. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Frindt G. et al. 2020. Ubiquitination of Renal ENaC Subunits in Vivo. Am J Physiol Renal Physiol. 2020 May 1;318(5):F1113-F1121. doi: 10.1152/ajprenal.00609.2019. Epub 2020 Mar 16. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Gu C. et al. 2020. Identification of Berberine as a Novel Drug for the Treatment of Multiple Myeloma via Targeting UHRF1. BMC Biol. 2020 Mar 25;18(1):33. doi: 10.1186/s12915-020-00766-8. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Manzione M. et al. 2020. Co-regulation of the Antagonistic RepoMan:Aurora-B Pair in Proliferating Cells. Mol Biol Cell. 2020 Mar 15;31(6):419-438. doi: 10.1091/mbc.E19-12-0698. Epub 2020 Jan 22. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Rivas J. et al. 2020. KCTD5, a Novel TRPM4-regulatory Protein Required for Cell Migration as a New Predictor for Breast Cancer Prognosis. Am J Physiol Renal Physiol. FASEB J. 2020 Apr 17. doi: 10.1096/fj.201901195RRR. Online ahead of print. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Wenzel HJ. et al. 2019. Astroglial-targeted expression of the fragile X CGG repeat premutation in mice yields RAN translation, motor deficits and possible evidence for cell-to-cell propagation of FXTAS pathology. Acta Neuropathol Commun. doi: 10.1186/s40478-019-0677-7. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: IF

Brophy M. et al. 2019. Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation. Circ Res. doi: 10.1161/CIRCRESAHA.118.313028. -- Anti-Ubiquitin Monoclonal: (AUB01) -- Application: WB

Martini V. et al. 2018. Abnormal regulation of BCR signalling by c-Cbl in chronic lymphocytic leukaemia. Oncotarget. doi: 10.18632/oncotarget.25951. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kit BK161(Ub) -- Application: IP

Alvarez A. et al. 2017. KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Front Cell Infect Microbiol. 2017 Oct 24;7:450. doi: 10.3389/fcimb.2017.00450. -- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kit BK161 (Ub) --Application: IP

Braganza A. et al. 2017. UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. J Biol Chem. Doi: 10.1074/jbc.M116.766824.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Horita H. et al. 2017. Identifying regulatory post-translational modifications of PD-L1: a focus on mono-ubiquitination. Neoplasia. DOI: 10.1016/j.neo.2017.02.006. -- Signal-Seeker™ kit BK161--Application: IP

Rahman H.N.A. et al. Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Cir Res. Doi: 10.1161/CIRCRESAHA.115.307679.-- Anti-Ubiquitin Monoclonal: (AUB01) --Application: WB

Hukema R.K. et al. Reversibility of neuropathology and motor deficits in an inducible mouse model for FXTAS. Hum Mol Genet. Doi: 10.1093/hmg/ddv216.-- Anti-Ubiquitin Monoclonal: (AUB01-S) --Application: IF

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

Ubiquitination White Paper -- Signal-Seeker™ kits: BK161 (Ub), Ubiquitination affinity beads (UBA01-beads), Ubiquitination control beads (CUB02), HRP-Anti-Ubiquitin Monoclonal: AUB01-HRP

Blaster Validation Data:

Oldfield, CJ. Et al. Muscle-specific sirtuin 3 overexpression does not attenuate the pathological effects of high-fat/high-sucrose feeding but does enhance cardiac SERCA2a activity https://doi.org/10.14814/phy2.14961 BlastR Rapid Lysate Prep Kit BLR01, BlastR Rapid Filtration Kit BLR02, BlastR™ Lysis/Dilution Buffer Kit BLR03

Tanimoto, A. et al. Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression doi: 10.1158/1078-0432.CCR-20-2853 BlastR Rapid Lysate Prep Kit BLR01

Horita H. et al. 2018. Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins. J. Vis. Exp. (131), e56912, doi:10.3791/56912. -- Signal-Seeker™ kits

ASCB 2016 Poster: Complete removal of genomic DNA from cell lysate enhances the quality of protein research -- BlastR™ Filter (BLR02)

BlastR™ Buffer Comparison with conventional lysis buffers -- BlastR™ Rapid Lysate Prep kit (BLR01, BLR02)

PTM crosstalk:

Horita H. et al. 2018. Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins. Proteomes. doi: 10.3390/proteomes6020024. -- Signal-Seeker™ kits

Horita H. et al. 2018. Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins. J. Vis. Exp. (131), e56912, doi:10.3791/56912. -- Signal-Seeker™ kits

Horita H. et al. 2017. A simple toolset to identify endogenous post-translational modifications for a target protein:a snapshot of the EGFR signaling pathway. Bioscience Reports. 37 BSR20170919 DOI: 10.1042/BSR20170919. -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3), BK163 (Ac)

ASCB 2017 Poster: Paclitaxel induces post-translational modifications of RhoGDI alpha: a potential mechanism to regulate RhoA activity -- Signal-Seeker™ kits: BK 162 (SUMO 2/3), and BK163 (Ac)

ASCB 2016 Poster: A Method to Examine Temporal Regulation of Endogenous PTMs on Any Protein of Interest: A Snapshot of the EGFR Signaling Pathway -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)

cJUN White Paper -- Signal-Seeker™ kits: BK160 (pY), BK161 (Ub), BK162 (SUMO 2/3)