Author | Title | Journal | Year | Article Link |
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Kumar N, Manoj et al. | Benzothiazole-[1,2,3]triazolo[5,1-a]isoindoles: Synthesis, anticancer activity, bioavailability and in silico studies against Gama-Tubulin protein | Journal of Molecular Structure | 2022 | ISSN 0022-2860 |
Yao, Yongfang et al. | Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors | Journal of Enzyme Inhibition and Medicinal Chemistry | 2022 | ISSN 1475-6374 |
Wang, Zhan et al. | Design, synthesis and biological evaluation of colchicine glycoconjugates as tubulin polymerization inhibitors | Bioorganic and Medicinal Chemistry | 2022 | ISSN 1464-3391 |
Ma, Juan et al. | Discovery of Novel 3,4-Dihydro-2(1H)-Quinolinone Sulfonamide Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity | Molecules | 2022 | ISSN 1420-3049 |
Würtz, Martin et al. | Modular assembly of the principal microtubule nucleator γ-TuRC | Nature Communications | 2022 | ISSN 2041-1723 |
Liu, Chao et al. | Synthesis and biological evaluation of BU-4664L derivatives as potential anticancer agents | Bioorganic and Medicinal Chemistry Letters | 2022 | ISSN 1464-3405 |
Wang, Guangcheng et al. | Design, synthesis and biological evaluation of novel 2-phenyl-4,5,6,7-tetrahydro-1H-indole derivatives as potential anticancer agents and tubulin polymerization inhibitors | Arabian Journal of Chemistry | 2022 | ISSN 1878-5352 |
Patel, Onisha et al. | Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1 | Communications Biology | 2021 | ISSN 2399-3642 |
Fareed, Momen R. et al. | New multi-targeted antiproliferative agents: Design and synthesis of ic261-based oxindoles as potential tubulin, ck1 and egfr inhibitors | Pharmaceuticals | 2021 | ISSN 1424-8247 |
Rahimzadeh Oskuei, Sara et al. | Design, synthesis and biological evaluation of novel imidazole-chalcone derivatives as potential anticancer agents and tubulin polymerization inhibitors | Bioorganic Chemistry | 2021 | ISSN 1090-2120 |
Liang, Dong et al. | Identification of anthelmintic parbendazole as a therapeutic molecule for HNSCC through connectivity map-based drug repositioning | Acta Pharmaceutica Sinica B | 2021 | ISSN 2211-3843 |
Sun, Chiao Yin et al. | LMBD1 protein participates in cell mitosis by regulating microtubule assembly | Biochemical Journal | 2021 | ISSN 1470-8728 |
Wang, Chao et al. | Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers | Journal of Enzyme Inhibition and Medicinal Chemistry | 2021 | ISSN 1475-6374 |
Würtz, Martin et al. | Reconstitution of the recombinant human γ-tubulin ring complex | Open Biology | 2021 | ISSN 2046-2441 |
Grohmann, Christoph et al. | Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors | Cell Death and Disease | 2021 | ISSN 2041-4889 |
Yang, Mei et al. | C118P, a novel microtubule inhibitor with anti-angiogenic and vascular disrupting activities, exerts anti-tumor effects against hepatocellular carcinoma | Biochemical Pharmacology | 2021 | ISSN 0006--2952 |
| Lead optimization of novel quinolone chalcone compounds by a structure-activity relationship (SAR) study to increase efficacy and metabolic stability | | 2021 | Article Link |
Shawky, Ahmed M. et al. | Novel pyrrolizines bearing 3,4,5-trimethoxyphenyl moiety: design, synthesis, molecular docking, and biological evaluation as potential multi-target cytotoxic agents | Journal of Enzyme Inhibition and Medicinal Chemistry | 2021 | ISSN 1475-6374 |
Woo, Jung AA et al. | β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy | Life science alliance | 2021 | ISSN 2575--1077 |
Liu, Qian et al. | Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action | Aging | 2020 | ISSN 1945-4589 |
Abdel-Rahman, Somaya A. et al. | Cyclohepta[ b]thiophenes as Potential Antiproliferative Agents: Design, Synthesis, in Vitro, and in Vivo Anticancer Evaluation | ACS Pharmacology and Translational Science | 2020 | ISSN 2575-9108 |
Barnes, Natalie G. et al. | A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors | Bioorganic and Medicinal Chemistry | 2020 | ISSN 1464-3391 |
Palumbo, Valeria et al. | Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerization | Journal of Cell Science | 2020 | ISSN 1477-9137 |
Mirzaei, Salimeh et al. | Synthesis, structure-activity relationship and molecular docking studies of novel quinoline-chalcone hybrids as potential anticancer agents and tubulin inhibitors | Journal of Molecular Structure | 2020 | ISSN 0022-2860 |
Chen, Shih Yin et al. | Exosomal 2′,3′-CNP from mesenchymal stem cells promotes hippocampus CA1 neurogenesis/neuritogenesis and contributes to rescue of cognition/learning deficiencies of damaged brain | Stem Cells Translational Medicine | 2020 | ISSN 2157-6580 |
Song, Ming Yu et al. | Exploring diverse-ring analogues on combretastatin a4 (Ca-4) olefin as microtubule-targeting agents | International Journal of Molecular Sciences | 2020 | ISSN 1422-0067 |
Ullah, Imran et al. | An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box Promotes Leishmania Tubulin Polymerization | ACS Infectious Diseases | 2020 | ISSN 2373-8227 |
Tariq, Ammarah et al. | In vitro reconstitution of branching microtubule nucleation | eLife | 2020 | ISSN 2050-084X |
Zhernov, Ilia et al. | Intrinsically Disordered Domain of Kinesin-3 Kif14 Enables Unique Functional Diversity | Current Biology | 2020 | ISSN 1879-0445 |
Zdioruk, Mykola et al. | A new inhibitor of tubulin polymerization kills multiple cancer cell types and reveals p21-mediated mechanism determining cell death after mitotic catastrophe | Cancers | 2020 | ISSN 2072-6694 |
Skidmore, Lillian et al. | ARX788, a site-specific anti-HER2 antibody–drug conjugate, demonstrates potent and selective activity in HER2-low and T-DM1–resistant breast and gastric cancers | Molecular Cancer Therapeutics | 2020 | ISSN 1538-8514 |
Wang, Yanming et al. | Antibody-drug conjugate using ionized CYS-linker-mmae as the potent payload shows optimal therapeutic safety | Cancers | 2020 | ISSN 2072-6694 |
Baker, Stacey J. et al. | A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent | Molecular Cell | 2020 | ISSN 1097-4164 |
Morita, Ken et al. | Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2 | Cell | 2020 | ISSN 1097-4172 |
Dillon, Gregory M. et al. | Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites | PLoS ONE | 2020 | ISSN 1932-6203 |
Zhai, Min'an et al. | 3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation | European Journal of Medicinal Chemistry | 2019 | ISSN 1768-3254 |
Su, Wenhui et al. | Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 2019 | ISSN 1530-6860 |
Wang, Yanming et al. | Novel silyl ether-based acid-cleavable antibody-MMAE conjugates with appropriate stability and efficacy | Cancers | 2019 | ISSN 2072-6694 |
Cui, Ying Jie et al. | Synthesis of novel pyrazole derivatives and their tumor cell growth inhibitory activity | Molecules | 2019 | ISSN 1420-3049 |
Shaik, Thoukhir B. et al. | Evaluation of Anticancer and Anti-Mitotic Properties of Quinazoline and Quinazolino-Benzothiadiazine Derivatives | Anti-Cancer Agents in Medicinal Chemistry | 2019 | ISSN 1871-5206 |
Sonawane, Vinay et al. | Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy | European Journal of Medicinal Chemistry | 2019 | ISSN 1768-3254 |
Xia, Xiaoyu et al. | Leukemia Cell Cycle Chemical Profiling Identifies the G2-Phase Leukemia Specific Inhibitor Leusin-1 | ACS Chemical Biology | 2019 | ISSN 1554-8937 |
Behbahani, Fatemeh Shaebani et al. | Synthesis and biological evaluation of novel benzo[c]acridine-diones as potential anticancer agents and tubulin polymerization inhibitors | Archiv der Pharmazie | 2019 | ISSN 1521-4184 |
Karimikia, Ehsan et al. | Colchicine-like β-acetamidoketones as inhibitors of microtubule polymerization: Design, synthesis and biological evaluation of in vitro anticancer activity | Iranian Journal of Basic Medical Sciences | 2019 | ISSN 2008-3874 |
Patterson, Jesse C. et al. | VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells | Cell Systems | 2019 | ISSN 2405-4720 |
Mao, Bai Ping et al. | CaMSAP2 is a microtubule minus-end targeting protein that regulates BTB dynamics through cytoskeletal organization | Endocrinology | 2019 | ISSN 1945-7170 |
Eberle-Singh, Jaime A. et al. | Effective delivery of a microtubule polymerization inhibitor synergizes with standard regimens in models of pancreatic ductal adenocarcinoma | Clinical Cancer Research | 2019 | ISSN 1557-3265 |
Lukinavičius, Gražvydas et al. | Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues | Chemical Science | 2018 | ISSN 2041-6539 |
Tian, Zhenhua et al. | Biological activity and interaction mechanism of the diketopiperazine derivatives as tubulin polymerization inhibitors | RSC Advances | 2018 | ISSN 2046-2069 |
Simpkins, Scott W. et al. | Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions | PLoS Computational Biology | 2018 | ISSN 1553-7358 |
Nixon, Gemma L. et al. | Repurposing and reformulation of the antiparasitic agent flubendazole for treatment of cryptococcal meningoencephalitis, a neglected fungal disease | Antimicrobial Agents and Chemotherapy | 2018 | ISSN 1098-6596 |
Sato-Kaneko, Fumi et al. | Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy | BioMed Research International | 2018 | ISSN 2314-6141 |
Dilworth, David et al. | The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability | Nucleic Acids Research | 2018 | ISSN 1362-4962 |
Huan, L C et al. | Exploration of Some Thiazolidine-2, 4-dione and 2-Oxoindoline Derivatives Incorporating 3, 4, 5-Trimethoxybenzyl Moiety as Novel Anticancer Agents | Letters in Drug … | 2018 | Article Link |
Qi, Jianguo et al. | Synthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors | European Journal of Medicinal Chemistry | 2018 | ISSN 1768-3254 |
Senese, Silvia et al. | Microtubins: A novel class of small synthetic microtubule targeting drugs that inhibit cancer cell proliferation | Oncotarget | 2017 | ISSN 1949-2553 |
Wieczorek, Anna et al. | Synthesis and evaluation of biological properties of ferrocenyl-podophyllotoxin conjugates | Dalton Transactions | 2017 | ISSN 1477-9234 |
Sun, Maolin et al. | Synthesis and bioevaluation of N,4-diaryl-1,3-thiazole-2-amines as tubulin inhibitors with potent antiproliferative activity | PLoS ONE | 2017 | ISSN 1932-6203 |
Zollo, Massimo et al. | PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment | Brain | 2017 | ISSN 1460-2156 |
Chen, Minfeng et al. | Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents | Journal of Clinical Investigation | 2017 | ISSN 1558-8238 |
Tantak, Mukund P. et al. | Design and synthesis of bis(indolyl)ketohydrazide-hydrazones: Identification of potent and selective novel tubulin inhibitors | European Journal of Medicinal Chemistry | 2017 | ISSN 1768-3254 |
Xu, Qile et al. | Design, synthesis and structure-Activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors | Scientific Reports | 2017 | ISSN 2045-2322 |
Kowalczyk, Karolina et al. | Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines | Dalton Transactions | 2017 | ISSN 1477-9234 |
Wu, Yue et al. | Design and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors | Scientific Reports | 2017 | ISSN 2045-2322 |
Fu, Ying et al. | The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts | Dalton Transactions | 2016 | ISSN 1477-9234 |
Cai, De et al. | YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo | Cancer Chemotherapy and Pharmacology | 2016 | ISSN 1432-0843 |
Magalhaes, Luma G. et al. | Discovery of a series of acridinones as mechanism-based tubulin assembly inhibitors with anticancer activity | PLoS ONE | 2016 | ISSN 1932-6203 |
Hasanpourghadi, Mohadeseh et al. | Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell | Journal of Experimental and Clinical Cancer Research | 2016 | ISSN 1756-9966 |
Pearson, Brandon L. et al. | Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration | Nature Communications | 2016 | ISSN 2041-1723 |
Yoshitake, Jun et al. | Modification of tau by 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP): Effects of nitric oxide-linked chemical modification on tau aggregation | Journal of Biological Chemistry | 2016 | ISSN 1083-351X |
Thapa, Pritam et al. | Far-Red Light-Activatable Prodrug of Paclitaxel for the Combined Effects of Photodynamic Therapy and Site-Specific Paclitaxel Chemotherapy | Journal of Medicinal Chemistry | 2016 | ISSN 1520-4804 |
Fukuda, Yasunori et al. | Tubulin is a molecular target of the Wnt-activating chemical probe | BMC Biochemistry | 2016 | ISSN 1471-2091 |
Kamal, Ahmed et al. | Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors | Organic and Biomolecular Chemistry | 2016 | ISSN 1477-0520 |
Fawzy, Iten M. et al. | Newly Designed and Synthesized Curcumin Analogs with in vitro Cytotoxicity and Tubulin Polymerization Activity | Chemical biology & drug design | 2015 | ISSN 1747--0285 |
Mu, Yan et al. | The novel tubulin polymerization inhibitor MHPT exhibits selective anti-tumor activity against rhabdomyosarcoma in vitro and in vivo | PLoS ONE | 2015 | ISSN 1932-6203 |
Xu, Qile et al. | Synthesis and biological evaluation of 3-alkyl-1,5-diaryl-1H-pyrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative activity | PLoS ONE | 2015 | ISSN 1932-6203 |
Seashore-Ludlow, Brinton et al. | Harnessing connectivity in a large-scale small-molecule sensitivity dataset | Cancer Discovery | 2015 | ISSN 2159-8290 |
Remers, William A. et al. | Synthesis and Antitumor Activity of Heterocycles Related to Carbendazim | Journal of Heterocyclic Chemistry | 2015 | ISSN 1943--5193 |
Sheldon, Jonathon E. et al. | Photoswitchable anticancer activity via trans-cis isomerization of a combretastatin A-4 analog | Organic and Biomolecular Chemistry | 2015 | ISSN 1477-0520 |
Calles, Antonio et al. | Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines | Molecular Oncology | 2015 | ISSN 1878-0261 |
Yan, Jun et al. | A novel synthetic compound exerts effective anti-tumour activity in vivo via the inhibition of tubulin polymerisation in A549 cells | Biochemical Pharmacology | 2015 | ISSN 1873-2968 |
Wu, Shaoyu et al. | Bis-cyclopropane analog of disorazole C1 is a microtubuledestabilizing agent active in ABCB1-overexpressing human colon cancer cells | Oncotarget | 2015 | ISSN 1949-2553 |
Shigehiro, Tsukasa et al. | Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation | PLOS ONE | 2014 | ISSN 1932--6203 |
Choi, Bo Hwa et al. | Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization | PLOS ONE | 2014 | ISSN 1932--6203 |
Senese, S. et al. | Chemical dissection of the cell cycle: Probes for cell biology and anti-cancer drug development | Cell Death and Disease | 2014 | ISSN 2041-4889 |
Lutz, Vanessa et al. | SAR studies on hydropentalene derivatives - Important core units of biologically active tetramic acid macrolactams and ptychanolides | Bioorganic and Medicinal Chemistry | 2014 | ISSN 1464-3391 |
Mei, Mei et al. | A new 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) derivative overcomes paclitaxel resistance by inhibiting MAPK signaling and increasing paclitaxel accumulation in breast cancer cells | PLoS ONE | 2014 | ISSN 1932-6203 |
Bio, Moses et al. | Far-red light activatable, multifunctional prodrug for fluorescence optical imaging and combinational treatment | Journal of Medicinal Chemistry | 2014 | ISSN 1520-4804 |
Mäki-Jouppila, Jenni H.E. et al. | Centmitor-1, a novel acridinyl-acetohydrazide, possesses similar molecular interaction field and antimitotic cellular phenotype as rigosertib, on 01910.Na | Molecular Cancer Therapeutics | 2014 | ISSN 1538-8514 |
Zhang, Qiu et al. | Anti-tumor selectivity of a novel Tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models | Biochemical Pharmacology | 2013 | ISSN 1873-2968 |
Bio, Moses et al. | Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry | Journal of Medicinal Chemistry | 2013 | ISSN 0022-2623 |
Zach, Frank et al. | The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association | Human molecular genetics | 2012 | ISSN 1460--2083 |
Sidhaye, Venkataramana K. et al. | A Novel Role for Aquaporin-5 in Enhancing Microtubule Organization and Stability | PLOS ONE | 2012 | ISSN 1932--6203 |
Nguyen, Tam Luong et al. | Evading Pgp activity in drug-resistant cancer cells: A structural and functional study of antitubulin furan metotica compounds | Molecular Cancer Therapeutics | 2012 | ISSN 1535-7163 |
Fitzgerald, Daniel P. et al. | TPI-287, a new taxane family member, reduces the brain metastatic colonization of breast cancer cells | Molecular Cancer Therapeutics | 2012 | ISSN 1535-7163 |
Kawaratani, Yasuyuki et al. | New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group | Bioorganic and Medicinal Chemistry | 2011 | ISSN 0968-0896 |
Dyrager, Christine et al. | Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents | Bioorganic & medicinal chemistry | 2011 | ISSN 1464--3391 |
Hwang, Ji Hwan et al. | Induction of tubulin polymerization and apoptosis in malignant mesothelioma cells by a new compound JBIR-23 | Cancer letters | 2011 | ISSN 1872--7980 |
Kim, Insook et al. | Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway | NeuroReport | 2011 | ISSN 0959-4965 |
Oussenko, Irina A. et al. | Effect of on 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation | Cancer Research | 2011 | ISSN 0008-5472 |