Spirochrome Probes for Bioimaging

Live-cell imaging probes developed by Spirochrome are cell-permeable compounds which stain microtubules (SiR-Tubulin), F-actin (SiR-Actin), Lysosomes (SiR-Lysosome) and chromosomal DNA (SiR-DNA) in living cells.  These probes were recently introduced in a landmark papers published in Nature Methods and Nature recently featured on the cover of the Journal of Biological Chemistry. Cytoskeleton also provides Spirochrome's premier mechanosensor probes (Flippers) which can detect membrane tension changes through their fluorescence lifetime changes. You can read about the development of Flippers Nature Chemistry.