Myosin ATPase Screening Services

At Cyto, we don’t just study motor proteins—we helped pioneer the field. With 30+ years of innovation in cytoskeletal tools, our contract research sets the gold standard for discovering and profiling myosin inhibitors. Let’s connect.

Myosin assay service overview

Cyto provides custom myosin assay services to support disease-focused research, including cardiomyopathies and hypercontractile disorders. Our platform emphasizes precision and biological relevance by addressing the fundamentals-utilizing highly purified, functionally active proteins. Standard F-actin stimulated myosin ATPase assays are complemented by advanced configurations such as calcium-activated thin-filament/myosin ATPase assays, providing enhanced physiological insight and flexibility for your research needs.

Myosin screening targets

Parameter	Services available	Datasheets	Inquire
Myosin source	Cardiac (bovine)-full length	CDS081	Custom Services Inquiry
	Cardiac (bovine)-S1	CDS083	Custom Services Inquiry
	Cardiac (bovine)-HMM	CDS082	Custom Services Inquiry
	Skeletal muscle (rabbit)-full length	CDS086	Custom Services Inquiry
	Skeletal muscle (rabbit)-S1	CDS087	Custom Services Inquiry
	Smooth muscle (gizzard)-full length	Item does not exist	Custom Services Inquiry
	Smooth-muscle (gizzard)-S1	CDS089	Custom Services Inquiry
Assay formats	F-actin enhanced myosin ATPase - Kinetic	CDS084	Custom Services Inquiry
	F-actin enhanced myosin ATPase-end-point	CDS085	Custom Services Inquiry
	Calcium activated myosin thin filament assay-kinetic	CDS080	Custom Services Inquiry

Why choose us?

Cytoskeleton partners closely with your team to deliver myosin screening services, leveraging deep expertise in cytoskeletal motor biology. Our high-quality data supports key project decisions, while our focus on collaboration and reliability keeps leading pharma and biotech companies returning year after year.

Proven expertise

Pioneer in myosin screens
Cutting-edge assays ready to go
Industry-leading protein quality

Collaborative approach

Weekly meetings with both the PhD project lead and a dedicated project manager
Client priorities consistently drive the agenda.
Clients retain full flexibility to change the project direction at any stage

Fast reliable delivery

Turn around for new projects as short as 2-3 weeks
The final report will be shaped in partnership with the client, incorporating their insights and approvals at key milestones

Reliable, robust results

Low variability ensures highly reproducible data
Rigorous, multi-parameter, QC protocol
Detailed documentation

Case Study

Mechanistic profiling of myosin

The objective

The client sought mechanistic insight into a panel of optimized lead compounds, specifically to determine their modulatory effects on the isolated myosin–thin filament complex. The objective was to implement a recurring screening workflow, executing a mechanistically informative assay every 4 weeks with a 1-week turnaround, to support structure-activity relationship (SAR) refinement and facilitate rapid decision-making.

The result

Leveraging Cyto’s deep expertise in myosin-targeted compound screening and rapid access to high-quality reagents, the project maintained strict adherence to a 1-week turnaround schedule. This high-frequency cadence enabled the client to iteratively assess the efficacy of the lead compound, interrogate actomyosin regulatory mechanisms in detail, and accelerate SAR cycles, thereby enabling data-driven prioritization of candidates with finely tuned modulation profiles and therapeutic potential.

Download case study

Our clients

We proudly support leading research teams across the pharmaceutical, biotechnology, and academic sectors. Our custom services have helped advance discovery and preclinical programs in oncology, neuroscience, cardiology, and beyond.

Merck & Co., Inc.
Eli Lilly & Co.
Amgen, Inc.
Abbott Laboratories
Pfizer, Inc.
Astra-Zeneca plc
GlaxoSmithKline plc
Genentech, Inc.
Johnson & Johnson
Bristol-Myers Squibb

Interested in a custom myosin screen or learning more? We’re here to help

Myosin assay service overview

Parameter

Services available

Datasheets

Inquire

Myosin source

Cardiac (bovine)-full length

CDS081

Custom Services Inquiry

Cardiac (bovine)-S1

CDS083

Custom Services Inquiry

Cardiac (bovine)-HMM

CDS082

Custom Services Inquiry

Skeletal muscle (rabbit)-full length

CDS086

Custom Services Inquiry

Skeletal muscle (rabbit)-S1

CDS087

Custom Services Inquiry

Smooth muscle (gizzard)-full length

Item does not exist

Custom Services Inquiry

Smooth-muscle (gizzard)-S1

CDS089

Custom Services Inquiry

Assay formats

F-actin enhanced myosin ATPase - Kinetic

CDS084

Custom Services Inquiry

F-actin enhanced myosin ATPase-end-point

CDS085

Custom Services Inquiry

Calcium activated myosin thin filament assay-kinetic

CDS080

Custom Services Inquiry

Why choose us?

Proven expertise

Pioneer in myosin screens
Cutting-edge assays ready to go
Industry-leading protein quality

Collaborative approach

Weekly meetings with both the PhD project lead and a dedicated project manager
Client priorities consistently drive the agenda.
Clients retain full flexibility to change the project direction at any stage

Fast reliable delivery

Turn around for new projects as short as 2-3 weeks
The final report will be shaped in partnership with the client, incorporating their insights and approvals at key milestones

Reliable, robust results

Low variability ensures highly reproducible data
Rigorous, multi-parameter, QC protocol
Detailed documentation