Service overview: GAP assays
GTPase-activating proteins (GAPs) targeting the Ras superfamily function by accelerating the intrinsic GTP hydrolysis activity of small G-proteins, thereby converting them from their active GTP-bound state to the inactive GDP-bound form. This inactivation downregulates signaling pathways dependent on active Ras GTPases. Our GAP assay platform utilizes a robust colorimetric detection system to monitor GAP-enhanced GTP hydrolysis, specifically measuring the release of inorganic phosphate as a readout of GAP activity.
