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    • Compound Screening
      • Tubulin Polymerization Assay Services
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About us

When accuracy matters, scientists turn to Cytoskeleton.

For over three decades, our proven tools for protein biochemistry and cell biology have helped researchers generate reproducible, publication-quality results—backed by expert support at every step.

50,000+

citations in scholarly journals

30+ years

of protein expertise

100+

novel kits and reagents

3-5

QC parameters per lot

Founded by scientists, for scientists

Since 1993, Cytoskeleton has combined scientific rigor with a passion for discovery. Founded by two biochemists, we specialize in protein biochemistry, cytoskeletal tools, and custom CRO services to help scientists conduct advanced research with confidence, consistency, and expert support.

With proprietary technologies like G-LISA® and Signal-Seeker™, and exclusive offerings from trusted supply partners, we provide the resources researchers need to generate meaningful, reproducible results.

Our mission

Our mission is to empower researchers with innovative, high-quality reagents, kits, and dedicated support to advance understanding of the biological mechanisms driving health and disease. We’re committed to providing comprehensive, user-friendly solutions that enable discoveries.

Our vision

We envision a future where specialists and non-specialists alike have the resources they need to address complex research challenges. By making advanced protein and cell biology accessible to all, we aim to drive meaningful breakthroughs that shape a better, healthier world.

Our history

Why scientists choose Cytoskeleton

Interested in joining our team?

Visit our Careers page to see current job openings and learn more about working at Cytoskeleton.

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Tel: 303-322-2254

  • Blogs
  • FAQ's
  • Datasheets and MSDS
  • Protocols
  • Learning Documents
  • Videos
  • About Us
  • Careers
  • Distributors
  • All Services
  • Compound Screening
  • Protein Purification
  • Assay Development
  • Post-Translational Modification (PTM) Tools
  • Motor Protein Products
  • Live Cell Imaging Reagents
  • Actin Products
  • ECM Proteins
  • Small G-protein Products
  • Tubulin & FtsZ Products
  • General Protein Tools
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1993

1993

Kim Middleton and Ashley Davis launch Cytoskeleton in a 150 sq ft San Diego lab.

1994

1994

Secure SBIR funding and relocate to Denver, Colorado to expand research capacity

1996

1996

Cyto is the first company to offer kinesin and myosin CRO services.

1997

1997

We license Dr. Alan Hall’s technology to lead small GTPase reagent commercialization.

2000

2000

Patent lyophilized tubulin formulations for safe global shipment of sensitive proteins

2005

2005

License HiLyte™ dyes, expanding our range of fluorescent probes

2009

2009

Patent G-LISA® assays for analysis of GTPases from limited sources like primary cells

2013

2013

Celebrate 20 years serving the scientific community

2015

2015

Launch patented Signal-Seeker® kits for detection of post-translational modifications

2016

2016

Begin exclusive partnership offering advanced live cell actin/tubulin Spirochrome™ probes

2019

2019

Launch advanced reagent line to study oxidized actins

2021

2021

Form exclusive partnership to offer advanced live cell MemGlow™ membrane probes

2025

2025

With our partner suppliers, we continue to expand our exciting live cell probe offerings.

2025

2025

Unveiled a faster, easier website built to enhance customer experience

Cytoskeleton’s technical support team took a genuine interest in our project and provided us with expert advice and insightful feedback whenever we had questions. The customer support quality that they offer is rare to come by these days. Thank you Cyto!”
Matthew O’Donohue

Matthew O’Donohue

Graduate Student

Southern Methodist University

What I really like about their kits is that they work, and what they say is going to happen, happens. It’s very clear to see and interpret results. Cytoskeleton kits work consistently over time and they’re just easy to work with.”
Robert Smith, PhD

Robert Smith, PhD

Associate Professor

Nova Southeastern University

In biology we need consistency and reproducibility in our assays and experiments. Whenever I see a product from Cytoskeleton, in my brain it's already fixed — okay good, I know I will get the consistency I need.”
Satya Malasala, PhD

Satya Malasala, PhD

Postdoctoral Scholar

University of South Carolina

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