Service overview: Tubulins
Tubulin-targeting compounds act by either stabilizing microtubules (MTs) or inducing their depolymerization. The most common screening method is an in vitro tubulin polymerization assay conducted under cell-free conditions, which confirms compound activity and enables the determination of IC₅₀/EC₅₀ based on polymerization kinetics. Additional approaches include binding competition assays at known sites (e.g., vinblastine, colchicine) and live-cell imaging. Cytoskeleton, Inc. offers all these screens using multiple tubulin sources.
