• Fluorogenic far-red probe for imaging microtubules in live cells and tissues
• Supports multicolor imaging

SiR-tubulin is based on the fluorophore silicon rhodamine (SiR) and the microtubule binding drug docetaxel. Sir-tubulin allows the labelling of microtubules in live cells with high specificity and low background.

Key features

• Ab: 652 nm, Em: 674 nm – far-red spectrum
• Emission in far-red minimizes phototoxicity and sample autofluorescence
• Cell-permeable
• Fluorogenic character: enhanced fluorescence when bound to microtubules
• Compatible with super-resolution microscopy (STED & SIM)

The biological activity of CY-SC002 is assessed by the ability of the probe to efficiently label microtubules in live cell HeLa culture. After a wash step, cell staining is visible for several hours. SiR-tubulin is not recommended for fixed cells.