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New Signal-Seeker™: PTM detection kits, antibodies, and reagents

Overview
Citations

Simplicity

Comprehensive kit minimizes optimization time, while maximizing PTM detection

Quality

Unparalleled sensitivity and precision to confidently identify low abundance PTMs

Integration

Study multiple PTMs using the same system

Validation Data

Browse through the products, resources, and background options below to see how Signal-Seeker™ kits and reagents can enhance your protein modification detection research.

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Cytoskeleton's products have been cited hundreds of times over the past 29 years. Example citations for the BK161 Ubiquitination Detection kit, BK161, is shown, but more citations are available on individual product pages. Please use the "Citations" tab on each individual product page.


AuthorTitleJournalYearArticle Link
Otani, Takahito et al.The role of adhesion molecules in osteocalcin-induced effects on glucose and lipid metabolism in adipocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research2024
Ruggeri, Edoardo et al.Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapyFrontiers in Immunology2024
Shi, Shujie et al.Control of ENaC ubiquitinationRenal Physiology2024
Kotani, Hiroshi et al.Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damageJournal of Biomedical Science2024
Hołda, Mateusz K. et al.Autophagy and ubiquitin-dependent proteolysis processes in left ventricular mass loss in pulmonary arterial hypertensionScientific Reports2024
Liu, Shiwei et al.O-GlcNAcylated RALY Contributes to Hepatocellular Carcinoma Cells Proliferation by Regulating USP22 mRNA Nuclear ExportInternational Journal of Biological Sciences2024
Yu, Hui et al.MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2Journal of Cellular and Molecular Medicine2024
Steinbach, Adriana et al.Cross-family small GTPase ubiquitination by the intracellular pathogen Legionella pneumophilaMolecular biology of the cell2024
Hotani, Takuma et al.Involvement of Protein Kinase R in Double-Stranded RNA-Induced Proteasomal Degradation of Hypoxia Inducible Factor-1αInflammation2023
Chen, Shanlin et al.Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cellsPhytotherapy Research2023
Guo, Qianjin et al.TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradationCell reports2023
Huang, Xiaogang et al.Unfolded protein response inhibits KAT2B/MLKL-mediated necroptosis of hepatocytes by promoting BMI1 level to ubiquitinate KAT2BOpen Medicine2023
Tahaei, Ebrahim et al.Pendrin regulation is prioritized by anion in high-potassium dietsAmerican Journal of Physiology - Renal Physiology2023
Wang, Yuan et al.MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradationCell Discovery 2023
Román-Fernández, Alvaro et al.Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic functionScience Advances2023
Yang Z. et. al.Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired ResistanceCancer Discov2022
Kholmanskikh, Stanislav et al.Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1Scientific Reports 2022 12:12022
Day-Walsh, Priscilla E. et al.Transcriptional and Post-Translational Regulation of Junctional Adhesion Molecule-B (JAM-B) in Leukocytes under Inflammatory StimuliInternational Journal of Molecular Sciences2022
Afrin, Sadia et al.Sim******* modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradationPharmacological Research2021
Tumova, Lucie et al.The ubiquitin-proteasome system does not regulate the degradation of porcine β-microseminoprotein during sperm capacitationInternational Journal of Molecular Sciences2020
Gu, Chunming et al.Identification of berberine as a novel drug for the treatment of multiple myeloma via targeting UHRF1BMC Biology2020
Chu, Yi et al.O-GlcNAcylation of SIX1 enhances its stability and promotes hepatocellular carcinoma proliferationTheranostics2020
Uchiyama, Makoto et al.O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel ResponsesCurrent Biology2020
Sen, Arpita et al.The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalizationJournal of Cell Science2020
Park, Jin Suk et al.Mechanical regulation of glycolysis via cytoskeleton architectureNature2020

Signal-Seeker PTM Detection Kits

  1. Signal-Seeker™ Ubiquitination Detection Kit (30 assay) BK161
    Signal-Seeker Ubquitination Detection Kit (30 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Acetyl-Lysine Detection Kit (30 assay) BK163
    Signal Seeker Acetylation Detection Kit (30 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ SUMOylation 2/3 Detection Kit (30 assay) BK162
    Signal Seeker SUMOylation 2/3 Detection Kit (30 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ SUMOylation 1 Detection Kit (30 assay) BK165
    Signal Seeker SUMOylation 1 Detection Kit (30 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Acetyl-Lysine Detection Kit - AAC03-Beads (30 assay) BK164
    Signal-Seeker™ Acetyl-Lysine Detection Kit - AAC03-Beads (30 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Phosphotyrosine Detection Kit (30 assay) BK160
    Signal Seeker Phosphotyrosine Detection Kit (30 assays, immunoprecipitation format)
    Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Ubiquitination Detection Kit (10 assay) BK161-S
    Signal-Seeker Ubquitination Detection Kit (10 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Acetyl-Lysine Detection Kit (15 assay) BK163-S
    Signal Seeker Acetylation Detection Kit (15 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ SUMOylation 2/3 Detection Kit (10 assay) BK162-S
    Signal Seeker SUMOylation 2/3 Detection Kit (10 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ SUMOylation 1 Detection Kit (10 assay) BK165-S
    Signal Seeker SUMOylation 1 Detection Kit (10 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS
  1. Signal-Seeker™ Phosphotyrosine Detection Kit (10 assay) BK160-S
    Signal Seeker Phosphotyrosine Detection Kit (10 assays, immunoprecipitation format) Learn More
    Datasheet
    MSDS

Signal-Seeker PTM Affinity Beads

  1. Ubiquitination Affinity Beads UBA01-beads
    Ubiquitination Affinity Beads (40 assays) Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Affinity Beads - AAC04 AAC04-Beads
    Acetyl-lysine Affinity Beads -AAC04 (40 Assays) Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Affinity Beads - AAC03 AAC03-Beads
    Acetyl-lysine Affinity Beads - AAC03 (40 Assays) Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Affinity Beads - AAC02 AAC02-Beads
    Acetyl-lysine Affinity Beads - AAC02 (40 Assays) Learn More
    Datasheet
    MSDS
  1. SUMOylation 2/3 Affinity Beads ASM24-Beads
    SUMO-2/3 Antibody Mouse Monoclonal (20 assays) (Agarose bead conjugate) Learn More
    Datasheet
    MSDS
  1. SUMOylation 1 Affinity Beads ASM11-beads
    SUMO1 Antibody Mouse Monoclonal (30 assays) (Agarose bead conjugate) Learn More
    Datasheet
    MSDS
  1. Phosphotyrosine Affinity Beads APY03-Beads
    Phosphotyrosine AffinityBeads (40 Assays) Learn More
    Datasheet
    MSDS
  1. Ubiquitination Control Beads CUB02-beads
    Ubiquitination Control Beads (10 assays) Learn More
    Datasheet
    MSDS
  1. IgG Control Beads CIG01-beads
    IgG Control Beads (10 assays) Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Control Beads CIG02-beads
    Acetyl Lysine Control Beads (10 assays) Learn More
    Datasheet
    MSDS
  1. SUMO1 IP Control Beads CIG03-beads
    SUMO1 IP Control Beads (12 assays) Learn More
    Datasheet
    MSDS

Signal-Seeker PTM True Antibodies

  1. Ubiquitin Antibody Mouse Monoclonal Cat. # AUB01
    Ubiquitin Mouse Monoclonal Antibody Learn More
    Datasheet
    MSDS
  1. Ubiquitin-HRP Antibody Mouse Monoclonal AUB01-HRP
    Ubiquitin-HRP Mouse Monoclonal Antibody Learn More
    Datasheet
    MSDS
  1. Acetyl Lysine Antibody Mouse Monoclonal AAC01
    Acetyl Lysine Mouse Monoclonal Antibody
    Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Antibody Mouse Monoclonal (7B5A1) AAC02
    Acetyl Lysine Mouse Monoclonal Antibody Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine Antibody Mouse Monoclonal (19C4B2.1) AAC03
    Acetyl Lysine Mouse Monoclonal Antibody
    Learn More
    Datasheet
    MSDS
  1. Acetyl-Lysine-HRP Antibody Mouse Monoclonal (19C4B2.1) AAC03-HRP
    Acetyl Lysine-HRP Mouse Monoclonal Antibody
    Learn More
    Datasheet
    MSDS
  1. SUMO-2/3 Antibody Mouse Monoclonal (Clone 12F3) ASM23
    SUMO-2/3 Antibody Mouse Monoclonal (Clone 12F3) Learn More
    Datasheet
    MSDS
  1. SUMO-2/3-HRP Antibody Mouse Monoclonal (Clone 12F3) ASM23-HRP
    SUMO-2/3-HRP Antibody Mouse Monoclonal (Clone 12F3) Learn More
    Datasheet
    MSDS
  1. SUMO1 Antibody Mouse Monoclonal (Clone 5D8B16) ASM01
    SUMO1 Antibody Mouse Monoclonal (Clone 5D8B16) Learn More
    Datasheet
    MSDS
  1. Phosphotyrosine Antibody Mouse Monoclonal 27B10 APY03
    Phosphotyrosine Mouse Monoclonal Antibody 27B10
    Learn More
    Datasheet
    MSDS
  1. Phosphotyrosine-HRP Mouse Monoclonal Antibody 27B10 APY03-HRP
    Phosphotyrosine-HRP Mouse Monoclonal Antibody 27B10 Learn More
    Datasheet
    MSDS

Signal-Seeker Actin Oxidation Tools

  1. MICAL-Oxidized Actin Protein (>95% pure): Rabbit Skeletal Muscle MXA95
    MICAL-Oxidized Actin Protein (>95% pure): Rabbit Skeletal Muscle (250 micrograms) Learn More
    Datasheet
    MSDS
  1. MICAL-Oxidized (Pyrene labeled) Actin Protein (>95% pure): Rabbit Skeletal Muscle MPAX1
    MICAL-Oxidized Pyrene Actin Protein (>95% pure): Rabbit Skeletal Muscle (250 micrograms) Learn More
    Datasheet
    MSDS
  1. MICAL-1 Protein 6xHis MIC01
    6xHis MICAL-1 Protein Redox-CH domains (2 x 50 micrograms) Learn More
    Datasheet
    MSDS
  1. MsrB2 Protein 6xHis MB201
    6xHis MsrB2 Protein aa: 42-182 (2 x 50 micrograms) Learn More
    Datasheet
    MSDS

Signal-Seeker BlastR Lysis System

  1. BlastR Rapid Lysate Prep Kit BLR01
    BlastR Rapid Lysate Prep Kit (50 filters) Learn More
    Datasheet
    MSDS
  1. BlastR Rapid Filtration Kit BLR02
    BlastR Rapid Filtration Kit (50 filters) Learn More
    Datasheet
    MSDS
  1. BlastR™ Lysis/Dilution Buffer Kit BLR03
    Learn More
    Datasheet
    MSDS

Select from the categories below:

Acetyl-Lysine Tools
Actin Oxidation Tools
Antibodies: PTMtrue™
BlastR™ Filter System
Phosphotyrosine Tools
SUMOylation 1 Tools
SUMOylation 2/3 Tools
Ubiquitination Tools
Browse Categories