• Fluorogenic far-red stain for DNA in live cells and tissues
• Compatible with long term imaging of live cells
• Fluorogenic far-red stain for DNA in fixed cells and tissues

SiR-DNA is based on the fluorophore silicon rhodamine (SiR) and the DNA minor groove binder bisbenzimide (Hoechst). Sir-DNA allows the labelling of DNA in live cells with high specificity and low background.

Key features

• Ab: 652 nm, Em: 674 nm – far-red spectrum
• Emission in far-red minimizes phototoxicity and sample autofluorescence
• Cell permeable
• Non-toxic
• Works on live or fixed cells
• Fluorogenic character: enhanced fluorescence when bound to DNA
• Compatible with widefield, confocal, STED & SIM imaging

The biological activity of CY-SC007 is assessed by the ability of the probe to efficiently label DNA in live human fibroblast cell culture. After an optional wash step, cell staining is visible for several hours. Omit the wash step for time lapse imaging.