Cytoskeleton Inc.

Therapeutic targeting of the Ubiquitin Pathway

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• Jul 22, 2021

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

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• Jul 8, 2021

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

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• Jun 22, 2021

KRAS No Longer Undruggable

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• Jun 8, 2021

Is the RAS Mimetic, Rigosertib a Tubulin Binding Agent?

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• May 18, 2021

Microtubules and Motor-Driven Cargo Delivery

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• May 4, 2021

Pro-inflammatory stressors alter the vesiculome of MIN6 pancreatic beta cells

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• Apr 13, 2021

A Tale of Two Myosin-Targeting Cardiac Drugs: A Rationale for Sarcomere Mechanistic Investigation

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• Mar 30, 2021

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

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• Mar 23, 2021

Small G-Proteins And Microvesicle-Mediated Cancer Biogenesis

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• Mar 16, 2021

SARS-CoV-2 infection alters the transcriptomic landscape of human airway cells

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• Feb 16, 2021

A Live Look At Membrane Tension At The Plasma Membrane And Beyond

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• Feb 2, 2021

RHOA-mediated mechanical force generation through Dectin-1

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• Jan 26, 2021

A highlight of Cytoskeleton's Activation Assays and their utility in several studies

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• Jan 12, 2021

New Minicatalog

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• Dec 16, 2020

Amyloid beta-induced F-actin destabilization alters dendritic spines in models of Alzheimer’s disease

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• Dec 8, 2020

Actin: Old Protein, New Tricks

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• Dec 1, 2020

Cyber Monday Sale Today

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• Nov 30, 2020

November 2020 Newsletter Investigating Exosomes - Tools and Implications

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• Nov 10, 2020

MICOS controls mitochondrial cristae formation

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• Nov 3, 2020

Newsletter Update: Coronavirus and the Cytoskeleton

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• Oct 28, 2020

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

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• Oct 22, 2020

October 2020 Newsletter: Mitotic Spindle - New Tools for Visualization

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• Oct 5, 2020

Halloween Special is Active

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• Oct 1, 2020

Citation Spotlight: Targeting The Cytoskeleton to Direct Pancreatic Differentiation of Human Pluripotent Stem Cells

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• Sep 3, 2020

August 2020 Newsletter: Fluorescent Membrane Probes

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• Aug 5, 2020

Citation Spotlight: Mechanical Regulation of Glycolysis via Cytoskeleton Architecture

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• Jul 28, 2020

Citation Spotlight: Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation

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• May 19, 2020

Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) Orchestrates Cytoskeletal and Transcriptional Changes of Host Neurons to Support Invasion

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• Apr 28, 2020

Citation Spotlight: Ubiquitination of renal ENaC subunits in vivo

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• Apr 15, 2020

April 2020 Newsletter: F-actin Probes in Living Cells

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• Apr 13, 2020

Virus infection induces RhoA Activation

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• Apr 7, 2020

Citation Spotlight:RhoA activation by SUN1/2 of the LINC complex controls actomyosin-dependent force generation and morphological changes in vascular smooth muscle cells

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• Mar 12, 2020

Spring Special is Active

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• Mar 3, 2020

February 2020 Newsletter : MAPping Tau's Future

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• Feb 25, 2020

Citation Spotlight: RhoA and NLRP3 inflammasome activation in in vivo and in vitro models of sepsis-induced intestinal dysfunction

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• Feb 6, 2020

December Newsletter: Actin Cytoskeleton and Mechanotransduction

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• Jan 14, 2020

January 2020 Newsletter : Rho GTPases Control Cell Migration

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• Jan 10, 2020

December 2019 Newsletter: Phenotropic Profiling Actin-focused Cancer Therapeutics

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• Jan 8, 2020

Citation Spotlight: Wnt5a regulation of RhoA-mediated remodeling of actin cytoskeleton to control ESCC cell motility

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• Jan 6, 2020

Citation Spotlight: Arp2/3 regulates RhoA activity and protein levels through cortactin/p190RhoGAP and CCM2/Smurf1, respectively

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• Jan 2, 2020

Citation Spotlight: Xenopus Egg Cytoplasm Self-assembles into Spatially Organized, Cell-like Compartments De Novo

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• Jan 2, 2020

Citation Spotlight: RCC2 Mediates Apoptosis Through Inhibition of GEF-Mediated Rac1 Activation

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• Dec 31, 2019

Citation Spotlight: RhoA Mediates Inhibition of Neurite Outgrowth by Amyloid Precursor Protein Homodimers

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• Dec 31, 2019

February Newsletter: Live Cell Imaging and CNS Diseases and Disorders

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• Dec 31, 2019

September 2019 Newsletter: Membrane Tension and Actin Cytoskeleton Interact to Regulate Cell Motility

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• Dec 23, 2019

Citation Spotlight:Transient Calcium Waves, Actin Dynamics, and Wound Healing

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• Dec 3, 2019

November 2019 Newsletter: Tubulin Hyperglutamylation, Mitochondria, and Neurodegeneration

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• Nov 5, 2019

Citation Spotlight: Polyglutamylation Regulates Motility of Neuron-specific KIF1A Kinesin

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• Oct 21, 2019

October 2019 Newsletter: RhoB GTPase Tumor Supporter or Suppressor?

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• Sep 30, 2019

Citation Spotlight: Novel Colchicine-binding Site Tubulin Inhibitor and Multi-drug Resistance

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• Aug 19, 2019

Citation Spotlight: RhoA-mediated morphological and functional plasticity in nucleus accumbens neurons

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• Aug 19, 2019

Citation Spotlight: Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner

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• Aug 19, 2019

August 2019 Newsletter Rac1B, Cancer, and Rac1

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• Aug 6, 2019

July Newsletter: Rho-family GTPases, Neuronal Plasticity, and Depression

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• Jul 19, 2019

May Newsletter: Microglia and Neurodegenerative Diseases

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• Jul 15, 2019

June Newsletter: Actin Methionine Oxidation: The Next Level of Dynamic Regulation

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• Jul 15, 2019

Citation Spotlight: Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

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• May 23, 2019

New 2019 Cytoskeleton Minicatalog

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• Feb 12, 2019

New 2018 Cytoskeleton Minicatalog

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• Feb 11, 2019

Citation Spotlight: Tctex-1, Novel Binding Partner of KIM-1, and Phagocytosis of Apoptotic Cells

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• Nov 12, 2018

November Newsletter: Axon Regeneration and the Cytoskeleton

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• Nov 1, 2018

Citation Spotlight: RhoA Activation and F-actin Stress Fiber Formation Underlies FAM13A-Mediated Changes in Cystic Fibrosis Lung Phenotype

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• Oct 9, 2018

October Newsletter: Microtubules and Polarity in Neurons

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• Oct 2, 2018

Citation Spotlight: Tubulysins: Novel Payload Class for Antibody-Drug Conjugates

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• Sep 17, 2018

Citation Spotlight: Misshapen Kinase Alters Actin Dynamics in the Regulation of Ring Canal Size and Stability

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• Aug 27, 2018

August Newsletter: Rab GTPases and Neurodegeneration

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• Aug 6, 2018

Citation Spotlight: RhoA Activation and Vascular Inflammation

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• Jul 23, 2018

July Newsletter: SUMO Wrestling: All About Balance

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• Jul 10, 2018

Citation Spotlight: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins

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• Jun 18, 2018

June Newsletter: Why Does K-Ras Display Oncogenic Specificity?

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• Jun 5, 2018

Citation Spotlight: Regulating RhoA Activity by Modulating RhoGDI Alpha Post-Translational Modifications

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• May 15, 2018

May Newsletter: Ubiquitin-Proteasome System as a Therapeutic Target: Does Tubulin Care?

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• Apr 30, 2018

Citation Spotlight: Anti-Psychotic Drug Aripiprazole Inhibits Cancer Cells via Src Inhibition

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• Apr 23, 2018

April Newsletter: Rho Family GEFs and Dendritic Spine Structural Plasticity

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• Apr 3, 2018

March Newsletter: Post-translational Modifications of β-catenin and TCF/LEF-1 Regulate Canonical Wnt Signaling

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• Mar 13, 2018

Citation Spotlight: Actin Bundling Protein EFhd2 Mediates LPS-Induced Macrophage Migration

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• Mar 6, 2018

February Newsletter: Post-translational Modifications Modulate p53 Tumor Suppressor Functions

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• Feb 20, 2018

Citation Spotlight: Tools and Protocols for Successful PTM Investigation for Target Proteins

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• Feb 8, 2018

January Newsletter: The GEF Trio and Its Role in Autism Spectrum Disorders

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• Jan 16, 2018

Citation Spotlight: Acetylated Microtubule Bundling, MAP Binding, and Functional Regulation of Kinesin-1

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• Jan 3, 2018

Citation Spotlight: Anti-cancer Therapeutic Buparlisib: Mitosis or PI3K Inhibitor?

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• Dec 18, 2017

December Newsletter: Profilin: Multi-functional Roles of an Actin Binding Protein

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• Dec 12, 2017

November Newsletter: Mitochondrial Acetylation: Emerging Concepts and Therapeutic Potential

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• Dec 11, 2017

Citation Spotlight: Vav2 GEF Binds Phosphorylated Cortactin for Activation of Rac3 in Invadopodia

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• Nov 21, 2017

Citation Spotlight: RhoA Activity Regulated by Src-Mediated Phosphorylation of ARHGAP42

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• Sep 21, 2017

September Newsletter: Microtubule Stabilization by the Post-translational Modification of Acetylation

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• Sep 11, 2017

August Newsletter: Actin Ring-Based Periodic Membrane Skeleton in Neuronal Axons

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• Aug 16, 2017

Citation Spotlight: Toolsets to Define PTMs for Any Target Protein

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• Aug 8, 2017

Citation Spotlight: Nanometer Scale Temperature Measurements of Myosin ATPase Activity

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• Jul 27, 2017

July Newsletter: Post-translational Regulation of Mdm2, an E3 Ubiquitin Ligase for Tumor Suppressor p53

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• Jul 26, 2017

Citation Spotlight: ARNO-Arf1 Pathway Regulates RhoA Activity to Control Podosome Formation

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• Jul 17, 2017

Citation Spotlight: Fibronectin Recycling and Fibrillogenesis Regulation by Transforming Growth Factor ß

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• Jun 14, 2017

June Newsletter: Posttranslational Regulation of Key Transcription Factors in Pluripotent Stem Cells

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• Jun 13, 2017

May Newsletter: Arf6 GEFs and Cancer Cell Invasion and Metastasis

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• May 16, 2017

April Newsletter: Post-translational Regulation of Phosphatase and Tensin Homolog (PTEN)

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• Apr 18, 2017

March Newsletter: Tau Post-Translational Modifications: Therapeutic Targets for Alzheimer’s Disease

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• Apr 6, 2017

Citation Spotlight: PD-L1: Regulation by the Post-Translational Modification of Monoubiquitination

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• Mar 29, 2017

Citation Spotlight: Selective G12D K-Ras Inhibitors Discovered via Phage Display Technology

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• Mar 16, 2017

February Newsletter: Actin-binding proteins and F-actin in dendrite cell migration

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• Mar 14, 2017

Citation Spotlight: Characterization of Novel 3D In Vitro Model of Cancer Cell Invasion

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• Feb 21, 2017

New 2017 Cytoskeleton Minicatalog

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• Feb 16, 2017

Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis

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• Jan 23, 2017

Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway

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• Dec 21, 2016

Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders

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• Dec 5, 2016

November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling

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• Nov 16, 2016

Citation Spotlight: Novel Tubulin Polymerization Inhibitor and Multidrug Resistance

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• Nov 10, 2016

Citation Spotlight: Rho GTPases and epidermal stem cell migration

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• Sep 29, 2016

September Newsletter: FtsZ Proteins: A Novel Anti-microbial Target

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• Sep 21, 2016

Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis

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• Sep 15, 2016

August Newsletter: Tyrosine phosphorylation regulates Rho family GTPase activity

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• Aug 3, 2016

July Newsletter: PTMs Regulate Cytoskeletal Proteins in Heart Disease

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• Jul 12, 2016

June Newsletter: Kinesin Motor Proteins and Neurodegeneration

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• Jul 5, 2016

Citation Highlight: Rac1: Essential for fibroblast-like synoviocyte migration, invasion, and activation

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• Jun 16, 2016

Citation Highlight: Microtubule Binding and Content Changes Induced by Excessive Alcohol

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• May 24, 2016

April Newsletter: Rac1 in Diabetes: The Good and Bad

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• Apr 18, 2016

PI3K/Akt/Rac1 activated by MMP-8 and TGF-ß1 interplay in hepatocellular carcinoma

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• Apr 13, 2016

Summer Special is Active!

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• Apr 2, 2016

Lysine Acetyltransferase p300 and Its Role in Skeletal Muscle Biology

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• Mar 24, 2016

SUMOylation: Functional Regulator of Cytoskeletal Proteins

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• Mar 9, 2016

Rho-family GTPases: Regulation by Opposing Tetraspanins in Dendritic Cells

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• Feb 9, 2016

RhoA and Cdc42 Activity Mediates Podoplanin-induced Tumor Progression

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• Feb 2, 2016

Vimentin Intermediate Filaments: Regulation by Phosphorylation

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• Jan 21, 2016

Rac1 Regulation ASCB 2015 Abstract

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• Jan 18, 2016

Rac1 Activity and SOD1 Aggregates

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• Dec 8, 2015

Anti-tumor activity of C36L1 peptide due to microtubule depolymerization

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• Nov 18, 2015

Dr. Alan Hall - GTPase Legacy

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• Sep 25, 2015

Tubulin Polymerization Inhibitor Screening

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• Aug 4, 2015

Post-translational Modifications - Essential for Protein Regulation

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• Aug 3, 2015

Live Cell Imaging of the Actin Cytoskeleton

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• Jul 6, 2015

SUMOylation of Mitotic Proteins: Localization and Function

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• Jun 2, 2015

Ras Cancer Therapeutics: 5 Promising Targets

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• May 1, 2015

YAP1 grabs the spotlight in oncogenic Ras addiction

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• Mar 26, 2015

Post-translational Modifications Regulate Ral GTPases

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• Mar 9, 2015

KSP/Eg5 Inhibition in Parasites and Fungi

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• Feb 2, 2015

Compound Screening, Protein Purification, Assay Development

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• Jan 30, 2015

KIF7 Kinesin Motor Assay

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• Jan 30, 2015

KSP/Eg5 Inhibition in Cancer: Theory and Therapy

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• Jan 30, 2015

Drugable site selection for KSP inhibitors

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• Jan 30, 2015

Phosphorylation of RhoA as a Regulator of Signal Transduction

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• Jan 26, 2015

GTPase Activation Assays: Detecting Different Isoforms

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• Jan 19, 2015

Citrullination: Taking the Charge out of Arg

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• Oct 23, 2014

Probing Sub-domains of Kinesin

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• Sep 8, 2014

SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins

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• Aug 4, 2014

New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

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• Jul 1, 2014

Rho GTPases and Reactive Oxygen Species: Crosstalk and Feedback

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• Jun 27, 2014

Myosin Acetylation Modulates Sarcomere Structure and Function

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• Apr 30, 2014

Lysine Acetylation - Regulator of Diverse Cellular Processes

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• Apr 3, 2014

Integrin-mediated redox control of beta-actin: PDI's Emergence

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• Mar 24, 2014

Dynein: One Motor, Multiple Neurodegenerative Diseases

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• Jan 20, 2014

Dynein: Hard working, but team oriented

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• Nov 1, 2013

Neurodegeneration: Rhes, SUMOylation, and Huntington's Disease

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• Sep 27, 2013

Ras and Rho Post-translational Modification by Prenylation

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• Sep 18, 2013

Monoubiquitination and Protein Regulation

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• Sep 10, 2013

Invasion by actin-driven membrane protrusions: Cortactin in focus

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• Aug 30, 2013

Actin Modifications and the Cytoskeleton

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• Aug 5, 2013

Life Inside a Microtubule

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• Jul 16, 2013

Tau PTMs as Therapeutic Targets

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• Mar 31, 2013

Idiopathic Pulmonary Fibrosis Drug Discovery using Fluorescent Fibronectin Proteins

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• Mar 5, 2013

New Arf1 and Arf6 Activation Assays

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• Jan 31, 2013

Dendritic Spines: Role of Arf6 in Development

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• Jan 4, 2013

Small molecule modulators of myosin

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• Nov 21, 2012

Ubiquitination and the Regulation of Rho Family Pathways

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• Oct 1, 2012

The Role of Rac1 GTPase in Neurodegeneration

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• Sep 4, 2012

Epithelial-Mesenchymal Transition (EMT) and the Involvement of Rho Family Small G-proteins

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• Jul 31, 2012

Polymodifications of tubulin: Glutamylation and Glycylation

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• Jul 2, 2012

The Extracellular Matrix Role in Cell Adhesion

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• May 31, 2012

2nd Annual Front Range Cytoskeleton Meeting, May 14th, 2012

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• May 3, 2012

Functions of the actin oxidation cycle

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• Apr 30, 2012

Trafficking: Arfs and the Cdc42/Rac connection

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• Mar 31, 2012

Cardiac Research Using G-LISA Technology

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• Feb 27, 2012

FtsZ Protein News

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• Feb 27, 2012

Neuroscience News

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• Dec 6, 2011

HDAC, Tubulin and Cortactin News

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• Oct 12, 2011

New Small G-protein Tools

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• Oct 12, 2011

Small G-protein Activation Assay News

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• Oct 12, 2011

Actin News – a major player in cell bio

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• Oct 12, 2011