Laminin the best known member of a family of basement membrane glycoproteins that play a role in cell adhesion, migration, growth and differentiation (2).  Laminins also promote neurite outgrowth and regeneration (3). Many of laminin’s functions are mediated by integrin cell surface receptors (2). Laminins are heterotrimers, composed of an a, b and g subunit (4). Laminin-1 from Engelbreth-Holm-Swarm (EHS) mouse tumor tissue has the composition a1b1g1 (also termed A1B1B2) and has an approximate molecular weight 850 kD, composed of a 400 kD alpha chain, a 225 kD beta and a 225 kD gamma chain (Figure 1).  


Read more about assays used to study Laminin (Click here).



  1. Guidebook to the extracellular matrix and adhesion proteins.  1993. Oxford University Press. Ed. Kreis T and Vale R.
  2. Scheele S et al. 2007. Laminin isoforms in development and disease.  J. Mol. Med. 85: 825-836.
  3. Edgar D. et al. 1984.  The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival. EMBO J. 3: 1463-1468.
  4. Burgeson R.E. et al. 1994.  A new nomenclature for the laminins. Matrix Biol. 14: 209-211.

Laminin (red fluorescent, rhodamine) (Cat. # LMN01)

Coelho-Sampaio, T. et al. Type IV collagen conforms to the organization of polylaminin adsorbed on planar substrata. Acta Biomater. 111, 242–253 (2020).

Zeng, J., Sasaki, N., Correia, C. R., Mano, J. F. & Matsusaki, M. Fabrication of Artificial Nanobasement Membranes for Cell Compartmentalization in 3D Tissues. Small 16, 1907434 (2020).

Maechler, Florian A et al. “Curvature-dependent constraints drive remodeling of epithelia.” Journal of cell science vol. 132,4 jcs222372. 24 Jan. 2019, doi:10.1242/jcs.222372

Lantoine, J. et al. Matrix stiffness modulates formation and activity of neuronal networks of controlled architectures. Biomaterials 89, 14–24 (2016).

Kim, J., Staunton, J. R. & Tanner, K. Independent Control of Topography for 3D Patterning of the ECM Microenvironment. Adv. Mater. 28, 132–137 (2016).

Kim, J. & Tanner, K. Three-Dimensional Patterning of the ECM Microenvironment Using Magnetic Nanoparticle Self Assembly. Curr. Protoc. Cell Biol. 70, 25.3.1-25.3.14 (2016).

Alessandri, K. et al. A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC). Lab Chip 16, 1593–1604 (2016).

Hinüber, C. et al. Hierarchically structured nerve guidance channels based on poly-3-hydroxybutyrate enhance oriented axonal outgrowth. Acta Biomater. 10, 2086–2095 (2014).

Laminin (green fluorescent, HiLyte488)

Coelho-Sampaio, T. et al. Type IV collagen conforms to the organization of polylaminin adsorbed on planar substrata. Acta Biomater. 111, 242–253 (2020).

Kent, A. J. et al. The microstructure of laminin-111 compensates for dystroglycan loss in mammary epithelial cells in downstream expression of milk proteins. Biomaterials 218, 119337 (2019).

Blehm, B. H., Jiang, N., Kotobuki, Y. & Tanner, K. Deconstructing the role of the ECM microenvironment on drug efficacy targeting MAPK signaling in a pre-clinical platform for cutaneous melanoma. Biomaterials 56, 129–139 (2015).

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