We are proud to announce that the PKmito™ probes for gentle imaging of mitochondria in live cells have been developed and published by the lab of Zhixing Chen from Peking University1,2). They were carefully designed to reduce the generation of reactive oxygen species during imaging and allow long-term imaging or timelapse STED imaging in live cells.
1. Liu Tianyan et al. “Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain” PNAS (2022):119 (52).
2. Yang, Zhongtian, et al. “Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging.” Chemical science 11.32 (2020): 8506-8516.
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