The Extracellular Matrix (ECM) is composed of collagen, non-collagenous glycoproteins and proteoglycans. These components are secreted from cells to create an ECM meshwork that surrounds cells and tissues. The ECM regulates many aspects of cellular function, including the cells' dynamic behavior, cytoskeletal organization and intercellular communication.
Fluorescent rhodamine fibronectin (Cat. # FNR01) treated MCF10Acells (image kindly provided by A. Varadaraj and M. Karthikeyan, Universityof South Carolina, Columbia, SC).