Newsletters and Citation Spotlights

Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition

Inhibiting The Rate-Limiting Lipogenic Enzymes That Characterize Cancer Cells

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton

A20 ubiquitin binding, not its catalytic activity, is important in Rheumatoid Arthritis (RA)

Zn2+ decoration of microtubules arrests axonal transport and displaces tau, doublecortin, and MAP2C

Novel Approaches to Study and Visualize Human Embryonic Development

Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension

Leveraging SUMOylation To Regulate Immune Response

ERK3/MAPK6 Dictates CDC42/RAC1 Activity and ARP2/3-Dependent Actin Polymerization

Mechanosensing By The ECM And Its Transmission To The Cytoskeleton

MTSS1 Curtails Lung Adenocarcinoma Immune Evasion by Promoting AIP4-Mediated PD-L1 Monoubiquitination and Lysosomal Degradation

RhoA/ROCK in Metabolic Syndrome

In Vitro Reconstitution of Cytoskeleton Networks - A Collection of Methods

Tubulin Alterations and Drug Resistance in Breast Cancer

MICAL1 activation by PAK1 mediates actin filament disassembly

Manipulation of Small GTPases by Pathogenic Bacteria

Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates

Regulation of Actin Cytoskeleton in Intestinal Epithelial Barrier Integrity and Inflammatory Bowel Disease

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

Dysfunctional Lysosomes Contribute To Lipid Droplet Accumulation In Fatty Liver Disease

Endothelial Notch signaling directly regulates the small GTPase RND1 to facilitate Notch suppression of endothelial migration

Motor Control: How Kinesins Drive Mitosis

MYO10-filopodia support basement membranes at pre-invasive tumor boundaries

Small but Mighty: The Emerging World of Microproteins

Elongator stabilizes microtubules to control central spindle asymmetry and polarized trafficking of cell fate determinants

Cell Membrane Manipulation By Scramblases

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodeling in neural crest cells

Disturbances in the Filamentous Actin Cytoskeleton Appear in Alzheimer’s Disease

Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite

September 2022 Newsletter: RhoA/ROCK Signaling in Cardiac Pathophysiology

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and is Associated with NESCAV Syndrome

Host–Pathogen Interactions and the Actin Cytoskeleton

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Regulation of Chromatin Accessibility in Cellular Reprogramming: Pioneer Transcription Factors, Epigenetics and Nuclear Actin

Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

Repurposing Colchicine To Treat Covid-19

Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates

Controlling Ubiquitination is Key in the War with Bacteria

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Oncogenic RAS signaling and Tumor Immune Evasion: Mechanisms and Therapeutic Opportunity

Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

Recent Discoveries on ABP’s and their Effect on Synaptic Plasticity

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

The Cytoskeleton’s Role In Autism Spectrum Disorder

Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis

The Structure of Microtubules - A Brief History

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

SARS-CoV-2 Evades Innate Immunity: Focusing on Ubiquitination

Degradation of Myofibrillar Actin and Myosin: Ubiquitin Machinery Identified

Rac1 And Cdc42 Pathways As Pivotal Axis In Future Metastatic Cancer Therapy

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis

Tubulin K40 Acetylation in Neurons: Novel Functions, Regulators, and Modifications

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Malaria influences the cytoskeleton during it’s lifecycle

Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex

Actin: a critical player in cancer cell immunosurveillance

Therapeutic targeting of the Ubiquitin Pathway

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

KRAS No Longer Undruggable

Is the RAS Mimetic, Rigosertib a Tubulin Binding Agent?

Microtubules and Motor-Driven Cargo Delivery

Pro-inflammatory stressors alter the vesiculome of MIN6 pancreatic beta cells

A Tale of Two Myosin-Targeting Cardiac Drugs: A Rationale for Sarcomere Mechanistic Investigation

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

Small G-Proteins And Microvesicle-Mediated Cancer Biogenesis

SARS-CoV-2 infection alters the transcriptomic landscape of human airway cells

A Live Look At Membrane Tension At The Plasma Membrane And Beyond

RHOA-mediated mechanical force generation through Dectin-1

A highlight of Cytoskeleton's Activation Assays and their utility in several studies

New Minicatalog

Amyloid beta-induced F-actin destabilization alters dendritic spines in models of Alzheimer’s disease

Actin: Old Protein, New Tricks

Cyber Monday Sale Today

November 2020 Newsletter Investigating Exosomes - Tools and Implications

MICOS controls mitochondrial cristae formation

Newsletter Update: Coronavirus and the Cytoskeleton

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

October 2020 Newsletter: Mitotic Spindle - New Tools for Visualization

Halloween Special is Active

Citation Spotlight: Targeting The Cytoskeleton to Direct Pancreatic Differentiation of Human Pluripotent Stem Cells

August 2020 Newsletter: Fluorescent Membrane Probes

Citation Spotlight: Mechanical Regulation of Glycolysis via Cytoskeleton Architecture

Citation Spotlight: Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation

Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) Orchestrates Cytoskeletal and Transcriptional Changes of Host Neurons to Support Invasion

Citation Spotlight: Ubiquitination of renal ENaC subunits in vivo

April 2020 Newsletter: F-actin Probes in Living Cells

Virus infection induces RhoA Activation

Citation Spotlight:RhoA activation by SUN1/2 of the LINC complex controls actomyosin-dependent force generation and morphological changes in vascular smooth muscle cells

Spring Special is Active

February 2020 Newsletter : MAPping Tau's Future

Citation Spotlight: RhoA and NLRP3 inflammasome activation in in vivo and in vitro models of sepsis-induced intestinal dysfunction

December Newsletter: Actin Cytoskeleton and Mechanotransduction

January 2020 Newsletter : Rho GTPases Control Cell Migration

December 2019 Newsletter: Phenotropic Profiling Actin-focused Cancer Therapeutics

Citation Spotlight: Wnt5a regulation of RhoA-mediated remodeling of actin cytoskeleton to control ESCC cell motility

Citation Spotlight: Arp2/3 regulates RhoA activity and protein levels through cortactin/p190RhoGAP and CCM2/Smurf1, respectively

Citation Spotlight: Xenopus Egg Cytoplasm Self-assembles into Spatially Organized, Cell-like Compartments De Novo

Citation Spotlight: RCC2 Mediates Apoptosis Through Inhibition of GEF-Mediated Rac1 Activation

Citation Spotlight: RhoA Mediates Inhibition of Neurite Outgrowth by Amyloid Precursor Protein Homodimers

February Newsletter: Live Cell Imaging and CNS Diseases and Disorders

September 2019 Newsletter: Membrane Tension and Actin Cytoskeleton Interact to Regulate Cell Motility

Citation Spotlight:Transient Calcium Waves, Actin Dynamics, and Wound Healing

November 2019 Newsletter: Tubulin Hyperglutamylation, Mitochondria, and Neurodegeneration

Citation Spotlight: Polyglutamylation Regulates Motility of Neuron-specific KIF1A Kinesin

October 2019 Newsletter: RhoB GTPase Tumor Supporter or Suppressor?

Citation Spotlight: Novel Colchicine-binding Site Tubulin Inhibitor and Multi-drug Resistance

Citation Spotlight: RhoA-mediated morphological and functional plasticity in nucleus accumbens neurons

Citation Spotlight: Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner

August 2019 Newsletter Rac1B, Cancer, and Rac1

July Newsletter: Rho-family GTPases, Neuronal Plasticity, and Depression

May Newsletter: Microglia and Neurodegenerative Diseases

June Newsletter: Actin Methionine Oxidation: The Next Level of Dynamic Regulation

Citation Spotlight: Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

New 2019 Cytoskeleton Minicatalog

New 2018 Cytoskeleton Minicatalog

Citation Spotlight: Tctex-1, Novel Binding Partner of KIM-1, and Phagocytosis of Apoptotic Cells

November Newsletter: Axon Regeneration and the Cytoskeleton

Citation Spotlight: RhoA Activation and F-actin Stress Fiber Formation Underlies FAM13A-Mediated Changes in Cystic Fibrosis Lung Phenotype

October Newsletter: Microtubules and Polarity in Neurons

Citation Spotlight: Tubulysins: Novel Payload Class for Antibody-Drug Conjugates

Citation Spotlight: Misshapen Kinase Alters Actin Dynamics in the Regulation of Ring Canal Size and Stability

August Newsletter: Rab GTPases and Neurodegeneration

Citation Spotlight: RhoA Activation and Vascular Inflammation

July Newsletter: SUMO Wrestling: All About Balance

Citation Spotlight: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins

June Newsletter: Why Does K-Ras Display Oncogenic Specificity?

Citation Spotlight: Regulating RhoA Activity by Modulating RhoGDI Alpha Post-Translational Modifications

May Newsletter: Ubiquitin-Proteasome System as a Therapeutic Target: Does Tubulin Care?

Citation Spotlight: Anti-Psychotic Drug Aripiprazole Inhibits Cancer Cells via Src Inhibition

April Newsletter: Rho Family GEFs and Dendritic Spine Structural Plasticity

March Newsletter: Post-translational Modifications of β-catenin and TCF/LEF-1 Regulate Canonical Wnt Signaling

Citation Spotlight: Actin Bundling Protein EFhd2 Mediates LPS-Induced Macrophage Migration

February Newsletter: Post-translational Modifications Modulate p53 Tumor Suppressor Functions

Citation Spotlight: Tools and Protocols for Successful PTM Investigation for Target Proteins

January Newsletter: The GEF Trio and Its Role in Autism Spectrum Disorders

Citation Spotlight: Acetylated Microtubule Bundling, MAP Binding, and Functional Regulation of Kinesin-1

Citation Spotlight: Anti-cancer Therapeutic Buparlisib: Mitosis or PI3K Inhibitor?

December Newsletter: Profilin: Multi-functional Roles of an Actin Binding Protein

November Newsletter: Mitochondrial Acetylation: Emerging Concepts and Therapeutic Potential

Citation Spotlight: Vav2 GEF Binds Phosphorylated Cortactin for Activation of Rac3 in Invadopodia

Citation Spotlight: RhoA Activity Regulated by Src-Mediated Phosphorylation of ARHGAP42

September Newsletter: Microtubule Stabilization by the Post-translational Modification of Acetylation

August Newsletter: Actin Ring-Based Periodic Membrane Skeleton in Neuronal Axons

Citation Spotlight: Toolsets to Define PTMs for Any Target Protein

Citation Spotlight: Nanometer Scale Temperature Measurements of Myosin ATPase Activity

July Newsletter: Post-translational Regulation of Mdm2, an E3 Ubiquitin Ligase for Tumor Suppressor p53

Citation Spotlight: ARNO-Arf1 Pathway Regulates RhoA Activity to Control Podosome Formation

Citation Spotlight: Fibronectin Recycling and Fibrillogenesis Regulation by Transforming Growth Factor ß

June Newsletter: Posttranslational Regulation of Key Transcription Factors in Pluripotent Stem Cells

May Newsletter: Arf6 GEFs and Cancer Cell Invasion and Metastasis

April Newsletter: Post-translational Regulation of Phosphatase and Tensin Homolog (PTEN)

March Newsletter: Tau Post-Translational Modifications: Therapeutic Targets for Alzheimer’s Disease

Citation Spotlight: PD-L1: Regulation by the Post-Translational Modification of Monoubiquitination

Citation Spotlight: Selective G12D K-Ras Inhibitors Discovered via Phage Display Technology

February Newsletter: Actin-binding proteins and F-actin in dendrite cell migration

Citation Spotlight: Characterization of Novel 3D In Vitro Model of Cancer Cell Invasion

New 2017 Cytoskeleton Minicatalog

Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis

Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway

Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders

November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling

Citation Spotlight: Novel Tubulin Polymerization Inhibitor and Multidrug Resistance

Citation Spotlight: Rho GTPases and epidermal stem cell migration

September Newsletter: FtsZ Proteins: A Novel Anti-microbial Target

Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis

August Newsletter: Tyrosine phosphorylation regulates Rho family GTPase activity

Inhibitors of hepatocyte growth factor-stimulated epithelial scattering also inhibit tubulin polymerization

July Newsletter: PTMs Regulate Cytoskeletal Proteins in Heart Disease

June Newsletter: Kinesin Motor Proteins and Neurodegeneration

Citation Highlight: Rac1: Essential for fibroblast-like synoviocyte migration, invasion, and activation

Citation Highlight: Microtubule Binding and Content Changes Induced by Excessive Alcohol

April Newsletter: Rac1 in Diabetes: The Good and Bad

PI3K/Akt/Rac1 activated by MMP-8 and TGF-ß1 interplay in hepatocellular carcinoma

Summer Special is Active!

Lysine Acetyltransferase p300 and Its Role in Skeletal Muscle Biology

SUMOylation: Functional Regulator of Cytoskeletal Proteins

Rho-family GTPases: Regulation by Opposing Tetraspanins in Dendritic Cells

RhoA and Cdc42 Activity Mediates Podoplanin-induced Tumor Progression

Vimentin Intermediate Filaments: Regulation by Phosphorylation

Rac1 Regulation ASCB 2015 Abstract

Rac1 Activity and SOD1 Aggregates

Anti-tumor activity of C36L1 peptide due to microtubule depolymerization

Dr. Alan Hall - GTPase Legacy

Tubulin Polymerization Inhibitor Screening

Post-translational Modifications - Essential for Protein Regulation

Live Cell Imaging of the Actin Cytoskeleton

SUMOylation of Mitotic Proteins: Localization and Function

Ras Cancer Therapeutics: 5 Promising Targets

YAP1 grabs the spotlight in oncogenic Ras addiction

Post-translational Modifications Regulate Ral GTPases

KSP/Eg5 Inhibition in Parasites and Fungi

Compound Screening, Protein Purification, Assay Development

KIF7 Kinesin Motor Assay

KSP/Eg5 Inhibition in Cancer: Theory and Therapy

Drugable site selection for KSP inhibitors

Phosphorylation of RhoA as a Regulator of Signal Transduction

GTPase Activation Assays: Detecting Different Isoforms

Citrullination: Taking the Charge out of Arg

Probing Sub-domains of Kinesin

SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins

New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

Rho GTPases and Reactive Oxygen Species: Crosstalk and Feedback

Myosin Acetylation Modulates Sarcomere Structure and Function

Lysine Acetylation - Regulator of Diverse Cellular Processes

Integrin-mediated redox control of beta-actin: PDI's Emergence

Dynein: One Motor, Multiple Neurodegenerative Diseases

Dynein: Hard working, but team oriented

Neurodegeneration: Rhes, SUMOylation, and Huntington's Disease

Ras and Rho Post-translational Modification by Prenylation

Monoubiquitination and Protein Regulation

Invasion by actin-driven membrane protrusions: Cortactin in focus

Actin Modifications and the Cytoskeleton

Life Inside a Microtubule

Tau PTMs as Therapeutic Targets

Idiopathic Pulmonary Fibrosis Drug Discovery using Fluorescent Fibronectin Proteins

New Arf1 and Arf6 Activation Assays

Dendritic Spines: Role of Arf6 in Development

Small molecule modulators of myosin

Ubiquitination and the Regulation of Rho Family Pathways

The Role of Rac1 GTPase in Neurodegeneration

Epithelial-Mesenchymal Transition (EMT) and the Involvement of Rho Family Small G-proteins

Polymodifications of tubulin: Glutamylation and Glycylation

The Extracellular Matrix Role in Cell Adhesion

2nd Annual Front Range Cytoskeleton Meeting, May 14th, 2012

Functions of the actin oxidation cycle

Trafficking: Arfs and the Cdc42/Rac connection

Cardiac Research Using G-LISA Technology

FtsZ Protein News

Neuroscience News

HDAC, Tubulin and Cortactin News

New Small G-protein Tools

Small G-protein Activation Assay News

Actin News – a major player in cell bio

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Newsletters and Citation Spotlights