Newsletters and Citation Spotlights

Differential cellular responses to adhesive interactions with galectin-8- and fibronectin-coated substrates

Controlling Ubiquitination is Key in the War with Bacteria

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Oncogenic RAS signaling and Tumor Immune Evasion: Mechanisms and Therapeutic Opportunity

Mechanosensitive smooth muscle cell phenotypic plasticity emerging from a null state and the balance between Rac and Rho

Recent Discoveries on ABP’s and their Effect on Synaptic Plasticity

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion

The Cytoskeleton’s Role In Autism Spectrum Disorder

Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis

The Structure of Microtubules - A Brief History

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

SARS-CoV-2 Evades Innate Immunity: Focusing on Ubiquitination

Degradation of Myofibrillar Actin and Myosin: Ubiquitin Machinery Identified

Rac1 And Cdc42 Pathways As Pivotal Axis In Future Metastatic Cancer Therapy

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis

Tubulin K40 Acetylation in Neurons: Novel Functions, Regulators, and Modifications

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Malaria influences the cytoskeleton during it’s lifecycle

Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex

Actin: a critical player in cancer cell immunosurveillance

Therapeutic targeting of the Ubiquitin Pathway

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

KRAS No Longer Undruggable

Is the RAS Mimetic, Rigosertib a Tubulin Binding Agent?

Microtubules and Motor-Driven Cargo Delivery

Pro-inflammatory stressors alter the vesiculome of MIN6 pancreatic beta cells

A Tale of Two Myosin-Targeting Cardiac Drugs: A Rationale for Sarcomere Mechanistic Investigation

YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow

Small G-Proteins And Microvesicle-Mediated Cancer Biogenesis

SARS-CoV-2 infection alters the transcriptomic landscape of human airway cells

A Live Look At Membrane Tension At The Plasma Membrane And Beyond

RHOA-mediated mechanical force generation through Dectin-1

A highlight of Cytoskeleton's Activation Assays and their utility in several studies

New Minicatalog

Amyloid beta-induced F-actin destabilization alters dendritic spines in models of Alzheimer’s disease

Actin: Old Protein, New Tricks

Cyber Monday Sale Today

November 2020 Newsletter Investigating Exosomes - Tools and Implications

MICOS controls mitochondrial cristae formation

Newsletter Update: Coronavirus and the Cytoskeleton

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

October 2020 Newsletter: Mitotic Spindle - New Tools for Visualization

Halloween Special is Active

Citation Spotlight: Targeting The Cytoskeleton to Direct Pancreatic Differentiation of Human Pluripotent Stem Cells

August 2020 Newsletter: Fluorescent Membrane Probes

Citation Spotlight: Mechanical Regulation of Glycolysis via Cytoskeleton Architecture

Citation Spotlight: Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation

Porcine Hemagglutinating Encephalomyelitis Virus (PHEV) Orchestrates Cytoskeletal and Transcriptional Changes of Host Neurons to Support Invasion

Citation Spotlight: Ubiquitination of renal ENaC subunits in vivo

April 2020 Newsletter: F-actin Probes in Living Cells

Virus infection induces RhoA Activation

Citation Spotlight:RhoA activation by SUN1/2 of the LINC complex controls actomyosin-dependent force generation and morphological changes in vascular smooth muscle cells

Spring Special is Active

February 2020 Newsletter : MAPping Tau's Future

Citation Spotlight: RhoA and NLRP3 inflammasome activation in in vivo and in vitro models of sepsis-induced intestinal dysfunction

December Newsletter: Actin Cytoskeleton and Mechanotransduction

January 2020 Newsletter : Rho GTPases Control Cell Migration

December 2019 Newsletter: Phenotropic Profiling Actin-focused Cancer Therapeutics

Citation Spotlight: Wnt5a regulation of RhoA-mediated remodeling of actin cytoskeleton to control ESCC cell motility

Citation Spotlight: Arp2/3 regulates RhoA activity and protein levels through cortactin/p190RhoGAP and CCM2/Smurf1, respectively

Citation Spotlight: Xenopus Egg Cytoplasm Self-assembles into Spatially Organized, Cell-like Compartments De Novo

Citation Spotlight: RCC2 Mediates Apoptosis Through Inhibition of GEF-Mediated Rac1 Activation

Citation Spotlight: RhoA Mediates Inhibition of Neurite Outgrowth by Amyloid Precursor Protein Homodimers

February Newsletter: Live Cell Imaging and CNS Diseases and Disorders

September 2019 Newsletter: Membrane Tension and Actin Cytoskeleton Interact to Regulate Cell Motility

Citation Spotlight:Transient Calcium Waves, Actin Dynamics, and Wound Healing

November 2019 Newsletter: Tubulin Hyperglutamylation, Mitochondria, and Neurodegeneration

Citation Spotlight: Polyglutamylation Regulates Motility of Neuron-specific KIF1A Kinesin

October 2019 Newsletter: RhoB GTPase Tumor Supporter or Suppressor?

Citation Spotlight: Novel Colchicine-binding Site Tubulin Inhibitor and Multi-drug Resistance

Citation Spotlight: RhoA-mediated morphological and functional plasticity in nucleus accumbens neurons

Citation Spotlight: Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner

August 2019 Newsletter Rac1B, Cancer, and Rac1

July Newsletter: Rho-family GTPases, Neuronal Plasticity, and Depression

May Newsletter: Microglia and Neurodegenerative Diseases

June Newsletter: Actin Methionine Oxidation: The Next Level of Dynamic Regulation

Citation Spotlight: Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

New 2019 Cytoskeleton Minicatalog

New 2018 Cytoskeleton Minicatalog

Citation Spotlight: Tctex-1, Novel Binding Partner of KIM-1, and Phagocytosis of Apoptotic Cells

November Newsletter: Axon Regeneration and the Cytoskeleton

Citation Spotlight: RhoA Activation and F-actin Stress Fiber Formation Underlies FAM13A-Mediated Changes in Cystic Fibrosis Lung Phenotype

October Newsletter: Microtubules and Polarity in Neurons

Citation Spotlight: Tubulysins: Novel Payload Class for Antibody-Drug Conjugates

Citation Spotlight: Misshapen Kinase Alters Actin Dynamics in the Regulation of Ring Canal Size and Stability

August Newsletter: Rab GTPases and Neurodegeneration

Citation Spotlight: RhoA Activation and Vascular Inflammation

July Newsletter: SUMO Wrestling: All About Balance

Citation Spotlight: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins

June Newsletter: Why Does K-Ras Display Oncogenic Specificity?

Citation Spotlight: Regulating RhoA Activity by Modulating RhoGDI Alpha Post-Translational Modifications

May Newsletter: Ubiquitin-Proteasome System as a Therapeutic Target: Does Tubulin Care?

Citation Spotlight: Anti-Psychotic Drug Aripiprazole Inhibits Cancer Cells via Src Inhibition

April Newsletter: Rho Family GEFs and Dendritic Spine Structural Plasticity

March Newsletter: Post-translational Modifications of β-catenin and TCF/LEF-1 Regulate Canonical Wnt Signaling

Citation Spotlight: Actin Bundling Protein EFhd2 Mediates LPS-Induced Macrophage Migration

February Newsletter: Post-translational Modifications Modulate p53 Tumor Suppressor Functions

Citation Spotlight: Tools and Protocols for Successful PTM Investigation for Target Proteins

January Newsletter: The GEF Trio and Its Role in Autism Spectrum Disorders

Citation Spotlight: Acetylated Microtubule Bundling, MAP Binding, and Functional Regulation of Kinesin-1

Citation Spotlight: Anti-cancer Therapeutic Buparlisib: Mitosis or PI3K Inhibitor?

December Newsletter: Profilin: Multi-functional Roles of an Actin Binding Protein

November Newsletter: Mitochondrial Acetylation: Emerging Concepts and Therapeutic Potential

Citation Spotlight: Vav2 GEF Binds Phosphorylated Cortactin for Activation of Rac3 in Invadopodia

Citation Spotlight: RhoA Activity Regulated by Src-Mediated Phosphorylation of ARHGAP42

September Newsletter: Microtubule Stabilization by the Post-translational Modification of Acetylation

August Newsletter: Actin Ring-Based Periodic Membrane Skeleton in Neuronal Axons

Citation Spotlight: Toolsets to Define PTMs for Any Target Protein

Citation Spotlight: Nanometer Scale Temperature Measurements of Myosin ATPase Activity

July Newsletter: Post-translational Regulation of Mdm2, an E3 Ubiquitin Ligase for Tumor Suppressor p53

Citation Spotlight: ARNO-Arf1 Pathway Regulates RhoA Activity to Control Podosome Formation

Citation Spotlight: Fibronectin Recycling and Fibrillogenesis Regulation by Transforming Growth Factor ß

June Newsletter: Posttranslational Regulation of Key Transcription Factors in Pluripotent Stem Cells

May Newsletter: Arf6 GEFs and Cancer Cell Invasion and Metastasis

April Newsletter: Post-translational Regulation of Phosphatase and Tensin Homolog (PTEN)

March Newsletter: Tau Post-Translational Modifications: Therapeutic Targets for Alzheimer’s Disease

Citation Spotlight: PD-L1: Regulation by the Post-Translational Modification of Monoubiquitination

Citation Spotlight: Selective G12D K-Ras Inhibitors Discovered via Phage Display Technology

February Newsletter: Actin-binding proteins and F-actin in dendrite cell migration

Citation Spotlight: Characterization of Novel 3D In Vitro Model of Cancer Cell Invasion

New 2017 Cytoskeleton Minicatalog

Citation Spotlight: Rac1 GTPase activity: Role in Lung Cancer Proliferation, Migration, and Metastasis

Citation Spotlight: Rho-Family GTPase Activity: Key Components of Anti-Inflammatory and Neuroprotective Pathway

Custom Services Newsletter: Rho Family GTPases and Central Nervous System Injuries, Diseases, and Disorders

November/December Newsletter: Small molecule inhibitors of GEF-mediated GTPase signaling

Citation Spotlight: Novel Tubulin Polymerization Inhibitor and Multidrug Resistance

Citation Spotlight: Rho GTPases and epidermal stem cell migration

September Newsletter: FtsZ Proteins: A Novel Anti-microbial Target

Citation Spotlight: Rho GTPases and SNX9: Cancer Cell Invasion and Metastasis

August Newsletter: Tyrosine phosphorylation regulates Rho family GTPase activity

Inhibitors of hepatocyte growth factor-stimulated epithelial scattering also inhibit tubulin polymerization

July Newsletter: PTMs Regulate Cytoskeletal Proteins in Heart Disease

June Newsletter: Kinesin Motor Proteins and Neurodegeneration

Citation Highlight: Rac1: Essential for fibroblast-like synoviocyte migration, invasion, and activation

Citation Highlight: Microtubule Binding and Content Changes Induced by Excessive Alcohol

April Newsletter: Rac1 in Diabetes: The Good and Bad

PI3K/Akt/Rac1 activated by MMP-8 and TGF-ß1 interplay in hepatocellular carcinoma

Summer Special is Active!

Lysine Acetyltransferase p300 and Its Role in Skeletal Muscle Biology

SUMOylation: Functional Regulator of Cytoskeletal Proteins

Rho-family GTPases: Regulation by Opposing Tetraspanins in Dendritic Cells

RhoA and Cdc42 Activity Mediates Podoplanin-induced Tumor Progression

Vimentin Intermediate Filaments: Regulation by Phosphorylation

Rac1 Regulation ASCB 2015 Abstract

Rac1 Activity and SOD1 Aggregates

Anti-tumor activity of C36L1 peptide due to microtubule depolymerization

Dr. Alan Hall - GTPase Legacy

Tubulin Polymerization Inhibitor Screening

Post-translational Modifications - Essential for Protein Regulation

Live Cell Imaging of the Actin Cytoskeleton

SUMOylation of Mitotic Proteins: Localization and Function

Ras Cancer Therapeutics: 5 Promising Targets

YAP1 grabs the spotlight in oncogenic Ras addiction

Post-translational Modifications Regulate Ral GTPases

KSP/Eg5 Inhibition in Parasites and Fungi

Compound Screening, Protein Purification, Assay Development

KIF7 Kinesin Motor Assay

KSP/Eg5 Inhibition in Cancer: Theory and Therapy

Drugable site selection for KSP inhibitors

Phosphorylation of RhoA as a Regulator of Signal Transduction

GTPase Activation Assays: Detecting Different Isoforms

Citrullination: Taking the Charge out of Arg

Probing Sub-domains of Kinesin

SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins

New Inhibitors to Control Ras signaling via Sos/K-Ras Binding

Rho GTPases and Reactive Oxygen Species: Crosstalk and Feedback

Myosin Acetylation Modulates Sarcomere Structure and Function

Lysine Acetylation - Regulator of Diverse Cellular Processes

Integrin-mediated redox control of beta-actin: PDI's Emergence

Dynein: One Motor, Multiple Neurodegenerative Diseases

Dynein: Hard working, but team oriented

Neurodegeneration: Rhes, SUMOylation, and Huntington's Disease

Ras and Rho Post-translational Modification by Prenylation

Monoubiquitination and Protein Regulation

Invasion by actin-driven membrane protrusions: Cortactin in focus

Actin Modifications and the Cytoskeleton

Life Inside a Microtubule

Tau PTMs as Therapeutic Targets

Idiopathic Pulmonary Fibrosis Drug Discovery using Fluorescent Fibronectin Proteins

New Arf1 and Arf6 Activation Assays

Dendritic Spines: Role of Arf6 in Development

Small molecule modulators of myosin

Ubiquitination and the Regulation of Rho Family Pathways

The Role of Rac1 GTPase in Neurodegeneration

Epithelial-Mesenchymal Transition (EMT) and the Involvement of Rho Family Small G-proteins

Polymodifications of tubulin: Glutamylation and Glycylation

The Extracellular Matrix Role in Cell Adhesion

2nd Annual Front Range Cytoskeleton Meeting, May 14th, 2012

Functions of the actin oxidation cycle

Trafficking: Arfs and the Cdc42/Rac connection

Cardiac Research Using G-LISA Technology

FtsZ Protein News

Neuroscience News

HDAC, Tubulin and Cortactin News

New Small G-protein Tools

Small G-protein Activation Assay News

Actin News – a major player in cell bio

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Newsletters and Citation Spotlights