Cytoskeleton Inc. - Signal-Seeker News

Molecular Glue Degraders: Ubiquitination Mediated Next-Generation Therapies

• Mar 7, 2024

SUMO Monoclonal Antibodies Vary in Sensitivity, Specificity, and Ability to Detect Types of SUMO Conjugate

• Feb 13, 2024

A20 ubiquitin binding, not its catalytic activity, is important in Rheumatoid Arthritis (RA)

• Oct 5, 2023

Leveraging SUMOylation To Regulate Immune Response

• Aug 8, 2023

MTSS1 Curtails Lung Adenocarcinoma Immune Evasion by Promoting AIP4-Mediated PD-L1 Monoubiquitination and Lysosomal Degradation

• Jun 20, 2023

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

• Feb 14, 2023

Regulation of Chromatin Accessibility in Cellular Reprogramming: Pioneer Transcription Factors, Epigenetics and Nuclear Actin

• Jul 6, 2022

Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

• Jun 23, 2022

Controlling Ubiquitination is Key in the War with Bacteria

• May 4, 2022

SARS-CoV-2 Evades Innate Immunity: Focusing on Ubiquitination

• Dec 2, 2021

Therapeutic targeting of the Ubiquitin Pathway

• Jul 22, 2021

O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses

• Jul 8, 2021

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

• Oct 22, 2020

Citation Spotlight: Mechanical Regulation of Glycolysis via Cytoskeleton Architecture

• Jul 28, 2020

Citation Spotlight: Ubiquitination of renal ENaC subunits in vivo

• Apr 15, 2020

Citation Spotlight: Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner

• Aug 19, 2019

June Newsletter: Actin Methionine Oxidation: The Next Level of Dynamic Regulation

• Jul 15, 2019

Citation Spotlight: Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation

• May 23, 2019

July Newsletter: SUMO Wrestling: All About Balance

• Jul 10, 2018

Citation Spotlight: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins

• Jun 18, 2018

May Newsletter: Ubiquitin-Proteasome System as a Therapeutic Target: Does Tubulin Care?

• Apr 30, 2018

March Newsletter: Post-translational Modifications of β-catenin and TCF/LEF-1 Regulate Canonical Wnt Signaling

• Mar 13, 2018

February Newsletter: Post-translational Modifications Modulate p53 Tumor Suppressor Functions

• Feb 20, 2018

Citation Spotlight: Tools and Protocols for Successful PTM Investigation for Target Proteins

• Feb 8, 2018

Citation Spotlight: Acetylated Microtubule Bundling, MAP Binding, and Functional Regulation of Kinesin-1

• Jan 3, 2018

November Newsletter: Mitochondrial Acetylation: Emerging Concepts and Therapeutic Potential

• Dec 11, 2017

September Newsletter: Microtubule Stabilization by the Post-translational Modification of Acetylation

• Sep 11, 2017

Citation Spotlight: Toolsets to Define PTMs for Any Target Protein

• Aug 8, 2017

July Newsletter: Post-translational Regulation of Mdm2, an E3 Ubiquitin Ligase for Tumor Suppressor p53

• Jul 26, 2017

June Newsletter: Posttranslational Regulation of Key Transcription Factors in Pluripotent Stem Cells

• Jun 13, 2017

April Newsletter: Post-translational Regulation of Phosphatase and Tensin Homolog (PTEN)

• Apr 18, 2017

Citation Spotlight: PD-L1: Regulation by the Post-Translational Modification of Monoubiquitination

• Mar 29, 2017

August Newsletter: Tyrosine phosphorylation regulates Rho family GTPase activity

• Aug 3, 2016

July Newsletter: PTMs Regulate Cytoskeletal Proteins in Heart Disease

• Jul 12, 2016

Lysine Acetyltransferase p300 and Its Role in Skeletal Muscle Biology

• Mar 24, 2016

SUMOylation: Functional Regulator of Cytoskeletal Proteins

• Mar 9, 2016

Vimentin Intermediate Filaments: Regulation by Phosphorylation

• Jan 21, 2016

Post-translational Modifications - Essential for Protein Regulation

• Aug 3, 2015

SUMOylation of Mitotic Proteins: Localization and Function

• Jun 2, 2015

Citrullination: Taking the Charge out of Arg

• Oct 23, 2014

SUMOylation: A Post-translational Modification Targeting Cytoskeletal Proteins

• Aug 4, 2014

Lysine Acetylation - Regulator of Diverse Cellular Processes

• Apr 3, 2014

Neurodegeneration: Rhes, SUMOylation, and Huntington's Disease

• Sep 27, 2013

Monoubiquitination and Protein Regulation

• Sep 10, 2013

Tau PTMs as Therapeutic Targets

• Mar 31, 2013

Ubiquitination and the Regulation of Rho Family Pathways

• Oct 1, 2012