Paclitaxel (Taxol)

Paclitaxel (Taxol)

Product Uses Include

  • Promote tubulin polymerization in vitro
  • Promote microtubule stability in vitro
  • Anti-mitotic drug in cell cultures

Paclitaxel's (Taxol) usefulness as a laboratory tool is well established and lies in its ability to inhibit microtubule depolymerization. Thus, taxol stabilized microtubules are used as substrates for the identification and characterization of the ever increasing number of microtubule associated proteins.

Paclitaxel is provided as a lyophilized powder. When resuspended in DMSO (not included) the paclitaxel is at 2 mM concentration.

In keeping with our policy of providing only the highest quality products, we are now pleased to inform you that Cytoskeleton is offering paclitaxel (taxol), from the Pacific yew tree, Taxus brevifolia, at a chromatographic purity of >99.5%. This is the purest taxol commercially available for research use.

Biological Activity
We have determined that the microtubule stabilizing property of our product is equal or superior to any other commercially available taxols. Microtubules in 10 µM paclitaxel are stable at room temperature for over one week.

For product Datasheets and MSDSs please click on the PDF links below.   For additional information, click on the FAQs tab above or contact our Technical Support department at

AuthorTitleJournalYearArticle Link
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Hoshino, Asumi et al.The microtubule-severing protein UNC-45A preferentially binds to curved microtubules and counteracts the microtubule-straightening effects of TaxolJournal of Biological Chemistry2023ISSN 1083-351X
Hoti, Qendresa et al.Avermectin B1a Shows Potential Anti-Proliferative and Anticancer Effects in HCT-116 Cells via Enhancing the Stability of MicrotubulesCurrent Issues in Molecular Biology 2023, Vol. 45, Pages 6272-62822023ISSN 1467--3045
Guerra San Juan, Irune et al.Loss of mouse Stmn2 function causes motor neuropathyNeuron2022ISSN 0896-6273
Feizabadi, Mitra Shojania et al.The Effect of Tau and Taxol on Polymerization of MCF7 Microtubules In VitroInternational Journal of Molecular Sciences2022ISSN 1422-0067
Gibson, James M et al.Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitmenteLife2022ISSN 2050-084X
Pizzi, Rita et al.Evidences of new biophysical properties of microtubulesFocus on Artificial Neural Networks2021Article Link
Sinclair, Amy N. et al.The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteinsPLOS Pathogens2021ISSN 1553--7374
Chang, Ting Yu et al.A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signalingBiomedicine and Pharmacotherapy2021ISSN 1950-6007
Habicht, Juri et al.UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin IIJournal of Cell Science2021ISSN 1477-9137
Qiu, Rongde et al.Dynein activation in vivo is regulated by the nucleotide states of its AAA3 domainCurrent Biology2021ISSN 1879-0445
Kaur, Simranpreet et al.Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A)Human Mutation2020ISSN 1098-1004
Li, Faxiang et al.Cryo-em structure of vash1-svbp bound to microtubuleseLife2020ISSN 2050-084X
Hao, Huiwen et al.Golgi‐associated microtubules are fast cargo tracks and required for persistent cell migrationEMBO reports2020ISSN 1469--221X
Ait-Bouziad, Nadine et al.Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- And lipid-binding properties of TauJournal of Biological Chemistry2020ISSN 1083-351X
Kalra, Aarat P. et al.Investigation of the electrical properties of microtubule ensembles under cell-like conditionsNanomaterials2020ISSN 2079-4991
Chiolerio, Alessandro et al.On resistance switching and oscillations in tubulin microtubule dropletsJournal of Colloid and Interface Science2020ISSN 1095-7103
Zhou, Chen et al.Structural basis of tubulin detyrosination by VASH2/SVBP heterodimerNature Communications2019ISSN 2041-1723
Schimert, Kristin I. et al.Intracellular cargo transport by single-headed kinesin motorsProceedings of the National Academy of Sciences of the United States of America2019ISSN 1091-6490
Huang, Chao et al.FoxM1 Induced Pac******* Resistance via Activation of the FoxM1/PHB1/RAF-MEK-ERK Pathway and Enhancement of the ABCA2 TransporterMolecular Therapy - Oncolytics2019ISSN 2372-7705
Guedes-Dias, Pedro et al.Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the PresynapseCurrent Biology2019ISSN 0960-9822
Li, Feiran et al.Local direction change of surface gliding microtubulesBiotechnology and Bioengineering2019ISSN 1097-0290
Tjioe, Marco et al.Multiple kinesins induce tension for smooth cargo transporteLife2019ISSN 2050-084X
Budaitis, Breane G. et al.Neck linker docking is critical for kinesin-1 force generation in cells but at a cost to motor speed and processivityeLife2019ISSN 2050-084X
Cloer, E. W. et al.p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2Molecular and Cellular Biology2018ISSN 0270--7306
Qiang, Liang et al.Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile DomainsCurrent Biology2018ISSN 0960-9822
Ganguly, Anindya et al.Importin-β Directly Regulates the Motor Activity and Turnover of a Kinesin-4Developmental Cell2018ISSN 1878-1551
Sladewski, Thomas E. et al.Recruitment of two dyneins to an mRNA-dependent bicaudal D transport complexeLife2018ISSN 2050-084X
McIntosh, Betsy B. et al.Opposing Kinesin and Myosin-I Motors Drive Membrane Deformation and Tubulation along Engineered Cytoskeletal NetworksCurrent Biology2018ISSN 0960-9822
Reinemann, Dana N. et al.Processive Kinesin-14 HSET Exhibits Directional Flexibility Depending on Motor TrafficCurrent Biology2018ISSN 0960-9822
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Question 1: Can I mix taxol with my cell culture media and store at 4°C?

Answer 1: No, we do not recommend storing cell culture media with taxol (Cat. # TXD01).  The taxol could precipitate out of solution at 4°C since the taxol is prepared in a 100% DMSO solution.  Instead, add taxol to warm cell culture media to be used on the day of the experiment.


Question 2: Can I incubate my cells with taxol to affect in vivo tubulin polymerization?

Answer 2: In-house testing demonstrates that 1 hour with 0.5 or 1 mM taxol (Cat. # TXD01) produces a robust increase in microtubules in Swiss 3T3 fibroblast cells.



If you have any questions concerning this product, please contact our Technical Service department at