Inhibitors

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Cytoskeleton's products have been cited hundreds of times over the past 18 years. A select few are described here, for more citations on individual products please use the "Citations" tab on each individual product page.

Q1: What is the selective range of CT04 in the Rho family of proteins.

A1: C3 transferase, which forms the basis of CT04, is selective for RhoA,B and C, but not Rac1 or Cdc42.

Q2: What should I know about the "Rac inhibitor" NSC23766 ?

A2: NSC23766 is not a classical inhibitor in the sense that it reduces the activity of all Rac1 activities or functions. In fact it has a limited range of target, it uncouples Rac from its GEF partners Tiam and Trio thus reducing the ability of these modulators to activate Rac. There are many other Rac GEFs in a cell so this inhibitor is quite restricted in its scope of targeting and should not be used as a general Rac inhibitor with out this knowledge.